{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:59:53Z","timestamp":1773496793058,"version":"3.50.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicol. Sci."],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1093\/toxsci\/kfw208","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T14:19:40Z","timestamp":1476195580000},"page":"283-297","source":"Crossref","is-referenced-by-count":9,"title":["Editor\u2019s Highlight: Comparative Renal Safety Assessment of the Hepatitis B Drugs, Adefovir, Tenofovir, Telbivudine and Entecavir in Rats"],"prefix":"10.1093","volume":"155","author":[{"given":"Marianne","family":"Uteng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Mahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolau","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Piaia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ledieu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Dubost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Tritto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Moulin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah-Dine","family":"Chibout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Pognan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,10,13]]},"reference":[{"key":"2017011104000706000_155.1.283.1","doi-asserted-by":"crossref","first-page":"S271","DOI":"10.1097\/00004424-198809001-00059","article-title":"Experimental study of DOTA-gadolinium. Pharmacokinetics and pharmacologic properties","volume":"23(Suppl. 1)","author":"Allard","year":"1988","journal-title":"Invest. Radiol."},{"key":"2017011104000706000_155.1.283.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0730-725X(00)00134-X"},{"key":"2017011104000706000_155.1.283.3","doi-asserted-by":"crossref","first-page":"574.","DOI":"10.1053\/hupa.2002.124012","article-title":"Adefovir nephrotoxicity and mitochondrial DNA depletion","volume":"33","author":"Bendele","year":"2002","journal-title":"Hum. Pathol."},{"key":"2017011104000706000_155.1.283.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2003.00399.x"},{"key":"2017011104000706000_155.1.283.5","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.3.716-723.2002"},{"key":"2017011104000706000_155.1.283.6","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199814000-00004"},{"key":"2017011104000706000_155.1.283.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2012.01600.x"},{"key":"2017011104000706000_155.1.283.8","doi-asserted-by":"publisher","DOI":"10.1086\/655681"},{"key":"2017011104000706000_155.1.283.9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/135965350601100108","article-title":"Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy","volume":"11","author":"Cote","year":"2006","journal-title":"Antivir. Ther"},{"key":"2017011104000706000_155.1.283.10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/jmri.24603","article-title":"Adriamycin-induced nephropathy in rats: Functional and cellular effects characterized by MRI","volume":"41","author":"Egger","year":"2015","journal-title":"J. Magn. Reson. Imaging"},{"key":"2017011104000706000_155.1.283.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"2017011104000706000_155.1.283.12","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/354908"},{"key":"2017011104000706000_155.1.283.13","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1002\/hep.22885","article-title":"Side effects of long-term oral antiviral therapy for hepatitis B","volume":"49(5 Suppl)","author":"Fontana","year":"2009","journal-title":"Hepatology"},{"key":"2017011104000706000_155.1.283.14","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12499"},{"key":"2017011104000706000_155.1.283.15","doi-asserted-by":"crossref","unstructured":"Gane E. J. Deray G. Liaw Y. F. Lim S. G. Lai C. L. Rasenack J. Wang Y. Papaptheodoridis G. Di Bisceglie A. Buti M. , . (2013). Telbivudine improves renal function in patients with chronic hepatitis B. Gastroenterology doi: 10.1053\/j.gastro.2013.09.031, 10.1053\/j.gastro.2013.09.031.x.","DOI":"10.1053\/j.gastro.2013.09.031"},{"key":"2017011104000706000_155.1.283.16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1053\/j.gastro.2013.09.031","article-title":"Telbivudine improves renal function in patients with chronic hepatitis B","volume":"146(1)","author":"Gane","year":"2014","journal-title":"Gastroenterology"},{"key":"2017011104000706000_155.1.283.17","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2007.09.004"},{"key":"2017011104000706000_155.1.283.18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23044"},{"key":"2017011104000706000_155.1.283.19","doi-asserted-by":"publisher","DOI":"10.1159\/000096860"},{"key":"2017011104000706000_155.1.283.20","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.01.022"},{"key":"2017011104000706000_155.1.283.21","doi-asserted-by":"crossref","first-page":"710-9","DOI":"10.1111\/apt.12251","article-title":"Resolution of adefovir-related nephrotoxicity by adefovir dose-reduction in patients with chronic hepatitis B","volume":"37","author":"Hartono","year":"2013","journal-title":"Aliment. Pharmacol. Ther."},{"key":"2017011104000706000_155.1.283.22","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.318"},{"key":"2017011104000706000_155.1.283.23","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050398"},{"key":"2017011104000706000_155.1.283.24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/978-1-4684-8953-8_25","article-title":"Nephrotoxicity of fumaric acid monoethylester (FA ME)","volume":"252","author":"Hohenegger","year":"1989","journal-title":"Adv. Exp. Med. Biol."},{"key":"2017011104000706000_155.1.283.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2005.11.007"},{"key":"2017011104000706000_155.1.283.26","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.02.010"},{"key":"2017011104000706000_155.1.283.27","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2003.50037"},{"key":"2017011104000706000_155.1.283.28","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.4.415.33182"},{"key":"2017011104000706000_155.1.283.29","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.24.2305"},{"key":"2017011104000706000_155.1.283.30","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(00)90004-3"},{"key":"2017011104000706000_155.1.283.31","doi-asserted-by":"publisher","DOI":"10.1086\/368314"},{"key":"2017011104000706000_155.1.283.32","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/00004424-199006000-00017","article-title":"Renal handling and physiologic effects of the paramagnetic contrast medium Gd-DOTA","volume":"25","author":"Katzberg","year":"1990","journal-title":"Invest. Radiol."},{"key":"2017011104000706000_155.1.283.33","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.14"},{"key":"2017011104000706000_155.1.283.34","doi-asserted-by":"crossref","first-page":"310\u20139, 10","DOI":"10.1111\/apt.13036","article-title":"Differences in nephrotoxicity risk and renal effects among anti-viral therapies against hepatitis B","volume":"41","author":"Koklu","year":"2015","journal-title":"Aliment. Pharmacol. Ther."},{"key":"2017011104000706000_155.1.283.35","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10034"},{"key":"2017011104000706000_155.1.283.36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2011.01278.x"},{"key":"2017011104000706000_155.1.283.37","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181a666eb"},{"key":"2017011104000706000_155.1.283.38","doi-asserted-by":"publisher","DOI":"10.1021\/bi035596s"},{"key":"2017011104000706000_155.1.283.39","doi-asserted-by":"crossref","first-page":"776","DOI":"10.5009\/gnl14297","article-title":"Comparison of the Effects of Telbivudine and Entecavir Treatment on Estimated Glomerular Filtration Rate in Patients with Chronic Hepatitis B","volume":"9","author":"Lee","year":"2015","journal-title":"Gut Liver"},{"key":"2017011104000706000_155.1.283.40","first-page":"407","article-title":"[Influence of monotherapy with telbivudine or entecavir on renal function in patients with chronic hepatitis B]","volume":"23","author":"Li","year":"2015","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"2017011104000706000_155.1.283.41","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24361"},{"key":"2017011104000706000_155.1.283.42","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23952"},{"key":"2017011104000706000_155.1.283.43","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00039-07"},{"key":"2017011104000706000_155.1.283.44","doi-asserted-by":"publisher","DOI":"10.1089\/apc.2011.0185"},{"key":"2017011104000706000_155.1.283.45","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020681"},{"key":"2017011104000706000_155.1.283.46","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1948-z"},{"key":"2017011104000706000_155.1.283.47","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1468-1293.2012.01054.x","article-title":"The early effects of stavudine compared with tenofovir on adipocyte gene expression, mitochondrial DNA copy number and metabolic parameters in South African HIV-infected patients: A randomized trial","volume":"14","author":"Menezes","year":"2013","journal-title":"HIV Med."},{"key":"2017011104000706000_155.1.283.48","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.140"},{"key":"2017011104000706000_155.1.283.49","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/apt.12538","article-title":"Review article: Nucleos(t)ide analogues in patients with chronic hepatitis B virus infection and chronic kidney disease","volume":"39","author":"Pipili","year":"2014","journal-title":"Aliment. Pharmacol. Ther."},{"key":"2017011104000706000_155.1.283.50","doi-asserted-by":"crossref","first-page":"e646","DOI":"10.1097\/MD.0000000000000646","article-title":"Impact of nucleos(t)ide analogue combination therapy on the estimated glomerular filtration rate in patients with chronic hepatitis B","volume":"94","author":"Qi","year":"2015","journal-title":"Medicine"},{"key":"2017011104000706000_155.1.283.51","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/jbt.21560","article-title":"Mitochondrial dysfunction and electron transport chain complex defect in a rat model of tenofovir disoproxil fumarate nephrotoxicity","volume":"28","author":"Ramamoorthy","year":"2014","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"2017011104000706000_155.1.283.52","doi-asserted-by":"publisher","DOI":"10.1081\/NCN-200059781"},{"key":"2017011104000706000_155.1.283.53","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00330-003-2005-6","article-title":"MR to assess renal function in children","volume":"13","author":"Rohrschneider","year":"2003","journal-title":"Eur. Radiol."},{"key":"2017011104000706000_155.1.283.54","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10334-008-0130-6","article-title":"Acute impairment of rat renal function by L-NAME as measured using dynamic MRI","volume":"21","author":"Sari-Sarraf","year":"2008","journal-title":"Magma"},{"key":"2017011104000706000_155.1.283.55","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1289\/ehp.93101s639","article-title":"Alpha 2u-globulin nephropathy: Review of the cellular and molecular mechanisms involved and their implications for human risk assessment","volume":"101(Suppl. 6)","author":"Swenberg","year":"1993","journal-title":"Environ. Health Perspect."},{"key":"2017011104000706000_155.1.283.56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2009.01160.x"},{"key":"2017011104000706000_155.1.283.57","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.25586"},{"key":"2017011104000706000_155.1.283.58","doi-asserted-by":"crossref","first-page":"O90","DOI":"10.1111\/1469-0691.12220","article-title":"A comparison of efficacy and safety of 2-year telbivudine and entecavir treatment in patients with chronic hepatitis B: A match-control study","volume":"20","author":"Tsai","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"2017011104000706000_155.1.283.59","first-page":"95.e1","article-title":"Comparison of renal safety and efficacy of telbivudine, entecavir and tenofovir treatment in chronic hepatitis B patients: Real world experience","volume":"22(1)","author":"Tsai","year":"2015","journal-title":"Clin. Microbiol. Infect"},{"key":"2017011104000706000_155.1.283.60","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1177\/135965350701200704","article-title":"Mitochondrial toxicity of tenofovir, emtricitabine and abacavir\u00a0alone and in combination with additional nucleoside reverse transcriptase inhibitors","volume":"12","author":"Venhoff","year":"2007","journal-title":"Antiviral Ther"},{"key":"2017011104000706000_155.1.283.61","doi-asserted-by":"crossref","first-page":"416","DOI":"10.4103\/1735-1995.158311","article-title":"Fanconi syndrome due to prolonged use of low-dose adefovir","volume":"20","author":"Wang","year":"2015","journal-title":"J. Res. Med. Sci"},{"key":"2017011104000706000_155.1.283.62","first-page":"438","article-title":"The use of telbivudine in kidney transplant recipients with chronic hepatitis b virus infection \u2013 A preliminary experience","volume":"21(5)","author":"Yap","year":"2015","journal-title":"Nephrology"},{"key":"2017011104000706000_155.1.283.63","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10051012"},{"key":"2017011104000706000_155.1.283.64","first-page":"287.e1","article-title":"A comparison of telbivudine and entecavir in the treatment of hepatitis B e antigen-positive patients: A prospective cohort study in China","volume":"22(3)","author":"Zhang","year":"2015","journal-title":"Clin. Microbiol. Infect"},{"key":"2017011104000706000_155.1.283.65","first-page":"794","article-title":"[Assessment of mitochondrial toxicity induced by zidovudine and adefovir dipivoxil in rats]","volume":"20","author":"Zhu","year":"2012","journal-title":"Zhonghua Gan Zang Bing Za Zhi"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/155\/1\/283\/9133653\/kfw208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T11:46:24Z","timestamp":1692531984000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article-lookup\/doi\/10.1093\/toxsci\/kfw208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,13]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,5]]},"published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1093\/toxsci\/kfw208"],"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfw208","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,13]]}}}