{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:34:27Z","timestamp":1788305667745,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000042"],"award-info":[{"award-number":["UL1 TR000042"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,4,1]]},"DOI":"10.1093\/toxsci\/kfx013","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T03:57:36Z","timestamp":1487131056000},"page":"520-526","source":"Crossref","is-referenced-by-count":14,"title":["Editor\u2019s Highlight: In Utero Exposure to Gadolinium and Adverse Neonatal Outcomes in Premature Infants"],"prefix":"10.1093","volume":"156","author":[{"given":"Radhika","family":"Amin","sequence":"first","affiliation":[{"name":"Pittsford Mendon High School, Pittsford, New York 14534;"},{"name":"Student Academic Internship Program, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York 14642;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Darrah","sequence":"additional","affiliation":[{"name":"School of Earth Sciences, The Ohio State University, Columbus, Ohio 43210-1398;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Rochester Medical Center, Rochester, New York 14642;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, University of Rochester Medical Center, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"key\n\t\t\t\t20180803090132_kfx013-B1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ejrad.2008.01.026","article-title":"Tissue distribution and kinetics of gadolinium and nephrogenic systemic fibrosis","volume":"66","author":"Abraham","year":"2008","journal-title":"Eur. J. Radiol."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jenvman.2012.04.040","article-title":"Sources of nutrients impacting surface waters in Florida: A review","volume":"109","author":"Badruzzaman","year":"2012","journal-title":"J. Environ. Manage."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B3","doi-asserted-by":"crossref","first-page":"C515","DOI":"10.1152\/ajpcell.1990.259.3.C515","article-title":"Gadolinium blocks low-and high-threshold calcium currents in pituitary cells","volume":"259","author":"Biagi","year":"1990","journal-title":"Am. J. Physiol"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ejrad.2008.02.011","article-title":"Nephrogenic systemic fibrosis associated with gadolinium based contrast agents: A summary of the medical literature reporting","volume":"66","author":"Broome","year":"2008","journal-title":"Eur. J. Radiol."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B5","doi-asserted-by":"crossref","first-page":"586","DOI":"10.2214\/AJR.06.1094","article-title":"Gadodiamide-associated nephrogenic systemic fibrosis: Why radiologists should be concerned","volume":"188","author":"Broome","year":"2007","journal-title":"Am. J. Roentgenol."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1039\/b905145g","article-title":"Incorporation of excess gadolinium into human bone from medical contrast agents","volume":"1","author":"Darrah","year":"2009","journal-title":"Metallomics: Integr. Biometal Sci"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/00016340600804639","article-title":"Gadolinium periconceptional exposure: Pregnancy and neonatal outcome","volume":"86","author":"De Santis","year":"2007","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1148\/radiology.176.1.2353096","article-title":"Cranial MR imaging with Gd-DTPA in neonates and young infants: Preliminary experience","volume":"176","author":"Elster","year":"1990","journal-title":"Radiology"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B9","first-page":"309","article-title":"Safety of gadolinium during pregnancy","volume":"52","author":"Garcia-Bournissen","year":"2006","journal-title":"Can. Family Physician Med. Famille Can."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B10","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1007\/s00247-004-1278-5","article-title":"Gadolinium-enhanced magnetic resonance angiography in neonates and infants suspected of caval or aortic thrombosis","volume":"34","author":"Greenberg","year":"2004","journal-title":"Pediatr. Radiol"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B11","author":"Grobner","year":"2006"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B12","doi-asserted-by":"crossref","first-page":"447.","DOI":"10.5694\/j.1326-5377.1995.tb124682.x","article-title":"Lead mobilisation during pregnancy","volume":"163","author":"Gulson","year":"1995","journal-title":"Med. J. Aust."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0022-2143(97)90058-5","article-title":"Pregnancy increases mobilization of lead from maternal skeleton","volume":"130","author":"Gulson","year":"1997","journal-title":"J. Lab. Clin. Med."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B14","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1021\/acs.est.5b04322","article-title":"Increases in anthropogenic gadolinium anomalies and rare earth element concentrations in San Francisco Bay over a 20 year record","volume":"50","author":"Hatje","year":"2016","journal-title":"Environ. Sci. Technol"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B15","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1472-8206.2006.00447.x","article-title":"Clinical and biological consequences of transmetallation induced by contrast agents for magnetic resonance imaging: A review","volume":"20","author":"Idee","year":"2006","journal-title":"Fundam. Clin. Pharmacol."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B16","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.envint.2011.02.018","article-title":"Rare earth elements in the Rhine River, Germany: First case of anthropogenic lanthanum as a dissolved microcontaminant in the hydrosphere","volume":"37","author":"Kulaksiz","year":"2011","journal-title":"Environ. Int."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B17","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/RLI.0000000000000280","article-title":"Revisiting the pharmacokinetic profiles of gadolinium-based contrast agents: Differences in long-term biodistribution and excretion","volume":"51","author":"Lancelot","year":"2016","journal-title":"Investigative Radiol."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s00247-008-1081-9","article-title":"Method for performing cerebral perfusion-weighted MRI in neonates","volume":"39","author":"Laswad","year":"2009","journal-title":"Pediatr. Radiol."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B19","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1093\/ndt\/gfm261","article-title":"Case-control study of gadodiamide-related nephrogenic systemic fibrosis","volume":"22","author":"Marckmann","year":"2007","journal-title":"Nephrol. Dialysis Transplant.: Official Publication of the European Dialysis and Transplant Association \u2013 European Renal Association"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B20","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1148\/radiology.205.2.9356634","article-title":"Normal placenta: Gadolinium-enhanced dynamic MR imaging","volume":"205","author":"Marcos","year":"1997","journal-title":"Radiology"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1476-5381.1991.tb12397.x","article-title":"Changes of quantal transmitter release caused by gadolinium ions at the frog neuromuscular junction","volume":"104","author":"Molgo","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B22","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1097\/00004728-199911001-00025","article-title":"Toxicological safety evaluation of gadobenate dimeglumine 0.5 M solution for injection (MultiHance), a new magnetic resonance imaging contrast medium","volume":"23(Suppl. 1)","author":"Morisetti","year":"1999","journal-title":"J. Comput. Assist. Tomogr."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B23","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/00004424-199328090-00015","article-title":"Gadolinium-DTPA transplacental transfer and distribution in fetal tissue in rabbits","volume":"28","author":"Novak","year":"1993","journal-title":"Invest. Radiol"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B100","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2131\/jts.24.SupplementI_79","article-title":"Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (3)--Study of embryo-fetal toxicity in rabbits by intravenous administration","volume":"24(Suppl 1)","author":"Okuda","year":"1999","journal-title":"Tox. Sci"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B24","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1148\/radiology.216.2.r00ma26610","article-title":"Gadolinium-enhanced MR imaging in the differential diagnosis of placenta accreta and placenta percreta","volume":"216","author":"Palacios Jaraquemada","year":"2000","journal-title":"Radiology"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B25","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1007\/s00247-012-2452-9","article-title":"Safety of cardiac magnetic resonance and contrast angiography for neonates and small infants: A 10-year single-institution experience","volume":"42","author":"Rangamani","year":"2012","journal-title":"Pediatr. Radiol"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B26","first-page":"365","article-title":"Neurotoxic effects of gadopentetate dimeglumine: Behavioral disturbance and morphology after intracerebroventricular injection in rats","volume":"17","author":"Ray","year":"1996","journal-title":"Am. J. Neuroradiol"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B27","doi-asserted-by":"crossref","DOI":"10.3174\/ajnr.A4891","article-title":"Pediatric patients demonstrate progressive T1-weighted hyperintensity in the dentate nucleus following multiple doses of gadolinium-based contrast agent","author":"Roberts","year":"2016","journal-title":"Am. J. Neuroradiol"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B28","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S1076-6332(05)80405-2","article-title":"Effect of magnetic resonance exposure combined with gadopentetate dimeglumine on chromosomes in animal specimens","volume":"2","author":"Rofsky","year":"1995","journal-title":"Acad. Radiol"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B29","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/jmri.1880040611","article-title":"Effect on fetal mouse development of exposure to MR imaging and gadopentetate dimeglumine","volume":"4","author":"Rofsky","year":"1994","journal-title":"J. Magn. Reson. Imaging"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B30","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10534-016-9931-7","article-title":"Gadolinium-based contrast agent toxicity: A review of known and proposed mechanisms","volume":"29","author":"Rogosnitzky","year":"2016","journal-title":"Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0883-2897(88)90158-4","article-title":"Gd-DTPA: An i.v. contrast agent for clinical MRI","volume":"15","author":"Runge","year":"1988","journal-title":"Int. J. Radiat. Appl. Instrum. Part B: Nucl. Med. Biol."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/00004836-199310000-00015","article-title":"MRI in the diagnosis of Crohn's disease in two pregnant women","volume":"17","author":"Shoenut","year":"1993","journal-title":"J. Clin. Gastroenterol."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B33","first-page":"S7","article-title":"Summary of preclinical safety evaluation of gadoteridol injection","volume":"27(Suppl. 1)","author":"Soltys","year":"1992","journal-title":"Invest. Radiol."},{"key":"key\n\t\t\t\t20180803090132_kfx013-B34","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1200\/JCO.2011.37.4025","article-title":"Impact of long-term serum platinum concentrations on neuro- and ototoxicity in Cisplatin-treated survivors of testicular cancer","volume":"30","author":"Sprauten","year":"2012","journal-title":"J. Clin. Oncol: Off. J. Am. Soc. Clin. Oncol"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B35","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/jmri.22413","article-title":"Is administration of gadolinium-based contrast media to pregnant women and small children justified?","volume":"34","author":"Sundgren","year":"2011","journal-title":"J. Magn. Reson. Imaging"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B36","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0730-725X(01)00388-5","article-title":"High temporal resolution dynamic contrast MRI in a high risk group for placenta accreta","volume":"19","author":"Tanaka","year":"2001","journal-title":"Magn. Reson. Imaging"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B37","author":"USEPA","year":"1991"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B38","author":"USEPA","year":"1993"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B39","author":"USEPA","year":"1994"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B40","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1007\/s00330-004-2583-y","article-title":"The use of iodinated and gadolinium contrast media during pregnancy and lactation","volume":"15","author":"Webb","year":"2005","journal-title":"Eur. Radiol"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B41","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00256-008-0464-1","article-title":"Nephrogenic systemic fibrosis: Chronic imaging findings and review of the medical literature","volume":"37","author":"Weigle","year":"2008","journal-title":"Skeletal Radiol"},{"key":"key\n\t\t\t\t20180803090132_kfx013-B42","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1126\/science.2466333","article-title":"Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions","volume":"243","author":"Yang","year":"1989","journal-title":"Science"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/156\/2\/520\/25423487\/kfx013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T14:09:48Z","timestamp":1568815788000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/156\/2\/520\/2997407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,1,23]]},"published-print":{"date-parts":[[2017,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfx013","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,4]]},"published":{"date-parts":[[2017,1,23]]}}}