{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:35:04Z","timestamp":1787009704093,"version":"build-2736575974"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01ES024516"],"award-info":[{"award-number":["R01ES024516"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270342"],"award-info":[{"award-number":["81270342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500216"],"award-info":[{"award-number":["81500216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302452"],"award-info":[{"award-number":["81302452"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GWTD2015S04"],"award-info":[{"award-number":["GWTD2015S04"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11,1]]},"DOI":"10.1093\/toxsci\/kfx154","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T15:13:01Z","timestamp":1501168381000},"page":"4-14","source":"Crossref","is-referenced-by-count":6,"title":["From the Cover: Lung-Specific Overexpression of Constitutively Active IKK2 Induces Pulmonary and Systemic Inflammations but Not Hypothalamic Inflammation and Glucose Intolerance"],"prefix":"10.1093","volume":"160","author":[{"given":"Minjie","family":"Chen","sequence":"first","affiliation":[{"name":"Cardiology Division, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201"},{"name":"Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201"},{"name":"Department of Pathology, Hubei University of Science and Technology, Xianning, Hubei 437100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianglin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201"},{"name":"Department of Occupational and Environmental Health, School of Public Health, Nantong University, Nantong 226019, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Hu","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201"},{"name":"Department of Endocrinology, The People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou, Henan 450003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Qin","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufang","family":"Chen","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Abu-Amer","sequence":"additional","affiliation":[{"name":"Orthopedics and Cell Biology & Physiology, Washington University School of Medicine, St Louis, Missouri63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhekang","family":"Ying","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201"},{"name":"Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"key\n\t\t\t\t20180328165624_kfx154-B1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00441-014-1905-x","article-title":"Primary alveolar macrophages exposed to diesel particulate matter increase RAGE expression and activate RAGE signaling","volume":"358","author":"Barton","year":"2014","journal-title":"Cell Tissue Res."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B2","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association","volume":"121","author":"Brook","year":"2010","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B3","doi-asserted-by":"crossref","first-page":"3.","DOI":"10.1186\/s12989-017-0183-7","article-title":"Prenatal and postnatal mothering by diesel exhaust PM2.5-exposed dams differentially program mouse energy metabolism","volume":"14","author":"Chen","year":"2017","journal-title":"Part Fibre Toxicol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/jat.1211","article-title":"Role of nuclear factor-kappa B activation in the adverse effects induced by air pollution particulate matter (PM2.5) in human epithelial lung cells (L132) in culture","volume":"27","author":"Dagher","year":"2007","journal-title":"J. Appl. Toxicol."},{"issue":"3","key":"key\n\t\t\t\t20180328165624_kfx154-B5","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/ni.3659","article-title":"Postprandial macrophage-derived IL-1beta stimulates insulin, and both synergistically promote glucose disposal and inflammation","volume":"18","author":"Dror","year":"2017","journal-title":"Nat. Immunol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s12020-015-0638-2","article-title":"Particulate matter pollutants and risk of type 2 diabetes: A time for concern?","volume":"51","author":"Esposito","year":"2016","journal-title":"Endocrine"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B7","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1476-5381.2011.01608.x","article-title":"Inhibitory kappa B Kinases as targets for pharmacological regulation","volume":"165","author":"Gamble","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.biopha.2016.11.094","article-title":"Histone deacetylases 3 deletion restrains PM2.5-induced mice lung injury by regulating NF-kappaB and TGF-beta\/Smad2\/3 signaling pathways","volume":"85","author":"Gu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B9","doi-asserted-by":"crossref","first-page":"E32","DOI":"10.1152\/ajpendo.00012.2016","article-title":"Neuroinflammatory and autonomic mechanisms in diabetes and hypertension","volume":"311","author":"Han","year":"2016","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3109\/08958378.2015.1045051","article-title":"PM2.5-rich dust collected from the air in Fukuoka, Kyushu, Japan, can exacerbate murine lung eosinophilia","volume":"27","author":"He","year":"2015","journal-title":"Inhal. Toxicol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1172\/JCI88878","article-title":"Hypothalamic inflammation in obesity and metabolic disease","volume":"127","author":"Jais","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"5","key":"key\n\t\t\t\t20180328165624_kfx154-B12","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/tox.22390","article-title":"Epidermal growth factor receptor (EGFR)-MAPK-nuclear factor(NF)-kappaB-IL8: A possible mechanism of particulate matter(PM) 2.5-induced lung toxicity","volume":"32","author":"Jeong","year":"2017","journal-title":"Environ. Toxicol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/ijerph2005010107","article-title":"Diesel exhaust particles induce the over expression of tumor necrosis factor-alpha (TNF-alpha) gene in alveolar macrophages and failed to induce apoptosis through activation of nuclear factor-kappaB (NF-kappaB)","volume":"2","author":"Kafoury","year":"2005","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B14","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/CIRCRESAHA.110.237560","article-title":"Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways","volume":"108","author":"Kampfrath","year":"2011","journal-title":"Circ. Res."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B15","doi-asserted-by":"crossref","first-page":"181643.","DOI":"10.1155\/2015\/181643","article-title":"Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and beta-Cell Dysfunction","volume":"2015","author":"Keane","year":"2015","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B16","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1164\/ajrccm.163.3.2003065","article-title":"Fas\/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice","volume":"163","author":"Kitamura","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/08958370902942517","article-title":"Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs","volume":"21(Suppl. 1)","author":"Kreyling","year":"2009","journal-title":"Inhal. Toxicol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B18","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1289\/ehp.1002986","article-title":"Diesel exhaust activates and primes microglia: Air pollution, neuroinflammation, and regulation of dopaminergic neurotoxicity","volume":"119","author":"Levesque","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B19","doi-asserted-by":"crossref","first-page":"20167","DOI":"10.1007\/s11356-015-5222-z","article-title":"Effects of ambient PM2.5 on pathological injury, inflammation, oxidative stress, metabolic enzyme activity, and expression of c-fos and c-jun in lungs of rats","volume":"22","author":"Li","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int"},{"issue":"2","key":"key\n\t\t\t\t20180328165624_kfx154-B20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/1091581816682225","article-title":"Fine Particulate Matter and Sulfur Dioxide Coexposures Induce Rat Lung Pathological Injury and Inflammatory Responses Via TLR4\/p38\/NF-kappaB Pathway","volume":"36","author":"Li","year":"2016","journal-title":"Int. J. Toxicol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B21","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.pupt.2012.12.010","article-title":"EM, EM703 inhibit NF-kB activation induced by oxidative stress from diesel exhaust particle in human bronchial epithelial cells: Importance in IL-8 transcription","volume":"26","author":"Li","year":"2013","journal-title":"Pulm. Pharmacol. Ther."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B22","doi-asserted-by":"crossref","first-page":"53.","DOI":"10.1186\/s12989-014-0053-5","article-title":"Central IKKbeta inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes","volume":"11","author":"Liu","year":"2014","journal-title":"Part. Fibre Toxicol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1177\/0192623312464531","article-title":"Epidemiological and experimental links between air pollution and type 2 diabetes","volume":"41","author":"Liu","year":"2013","journal-title":"Toxicol. Pathol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/01902148.2014.977461","article-title":"Alveolar NF-kappaB signaling regulates endotoxin-induced lung inflammation","volume":"41","author":"Lopez","year":"2015","journal-title":"Exp. Lung Res."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/08958370590912914","article-title":"Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. VIII. Source-related daily variations in invitro responses to CAPs","volume":"17","author":"Maciejczyk","year":"2005","journal-title":"Inhal. Toxicol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B26","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/s12020-016-0993-7","article-title":"Cooling down inflammation in type 2 diabetes: How strong is the evidence for cardiometabolic benefit?","volume":"55","author":"Maiorino","year":"2017","journal-title":"Endocrine"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B27","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.toxlet.2010.07.002","article-title":"Comparative acute lung inflammation induced by atmospheric PM and size-fractionated tire particles","volume":"198","author":"Mantecca","year":"2010","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B28","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.toxlet.2003.12.007","article-title":"The role of nitric oxide in the particulate matter (PM2.5)-induced NFkappaB activation in lung epithelial cells","volume":"148","author":"Nam","year":"2004","journal-title":"Toxicol. Lett."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B29","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1080\/00984100290071658","article-title":"Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats","volume":"65","author":"Oberdorster","year":"2002","journal-title":"J. Toxicol. Environ. Health A"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B30","doi-asserted-by":"crossref","DOI":"10.1289\/ehp.110-a440","article-title":"Ultrafine particles in the urban air: To the respiratory tract\u2013and beyond?","volume":"110","author":"Oberdorster","year":"2002","journal-title":"Environ. Health Perspect"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B31","doi-asserted-by":"crossref","first-page":"112.","DOI":"10.1186\/1476-069X-13-112","article-title":"Vascular and lung function related to ultrafine and fine particles exposure assessed by personal and indoor monitoring: A cross-sectional study","volume":"13","author":"Olsen","year":"2014","journal-title":"Environ. Health"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B32","doi-asserted-by":"crossref","first-page":"e38694.","DOI":"10.1371\/journal.pone.0038694","article-title":"Constitutively active canonical NF-kappaB pathway induces severe bone loss in mice","volume":"7","author":"Otero","year":"2012","journal-title":"PloS One"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B33","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1038\/sj.onc.1203239","article-title":"Activators and target genes of Rel\/NF-kappaB transcription factors","volume":"18","author":"Pahl","year":"1999","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B34","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.116.309279","article-title":"Exposure to fine particulate air pollution is associated with endothelial injury and systemic inflammation","volume":"119","author":"Pope","year":"2016","journal-title":"Circ. Res."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/08958378.2011.566290","article-title":"Low dose of fine particulate matter (PM2.5) can induce acute oxidative stress, inflammation and pulmonary impairment in healthy mice","volume":"23","author":"Riva","year":"2011","journal-title":"Inhal. Toxicol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B36","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1002\/smll.200800922","article-title":"Biodistribution of 1.4- and 18-nm gold particles in rats","volume":"4","author":"Semmler-Behnke","year":"2008","journal-title":"Small"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B37","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1161\/CIRCULATIONAHA.108.799015","article-title":"Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity","volume":"119","author":"Sun","year":"2009","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B38","doi-asserted-by":"crossref","first-page":"11858","DOI":"10.1074\/jbc.275.16.11858","article-title":"Conditional expression of fibroblast growth factor-7 in the developing and mature lung","volume":"275","author":"Tichelaar","year":"2000","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B39","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1126\/science.355.6323.342","article-title":"The polluted brain","volume":"355","author":"Underwood","year":"2017","journal-title":"Science"},{"key":"key\n\t\t\t\t20180328165624_kfx154-B40","doi-asserted-by":"crossref","first-page":"39.","DOI":"10.3389\/fcell.2017.00039","article-title":"Pulmonary Extracellular Vesicles as Mediators of Local and Systemic Inflammation","volume":"5","author":"Wahlund","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B41","doi-asserted-by":"crossref","first-page":"L758","DOI":"10.1152\/ajplung.00185.2014","article-title":"Acute secondhand smoke-induced pulmonary inflammation is diminished in RAGE knockout mice","volume":"307","author":"Wood","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B42","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1161\/CIRCRESAHA.113.301510","article-title":"Inhibitor kappaB kinase 2 is a myosin light chain kinase in vascular smooth muscle","volume":"113","author":"Ying","year":"2013","journal-title":"Circ. Res."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B43","doi-asserted-by":"crossref","first-page":"15.","DOI":"10.1186\/s12989-015-0092-6","article-title":"Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats","volume":"12","author":"Ying","year":"2015","journal-title":"Part. Fibre Toxicol."},{"key":"key\n\t\t\t\t20180328165624_kfx154-B44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1289\/ehp.1307151","article-title":"Long-term exposure to concentrated ambient PM2.5 increases mouse blood pressure through abnormal activation of the sympathetic nervous system: A role for hypothalamic inflammation","volume":"122","author":"Ying","year":"2014","journal-title":"Environ. Health Perspect."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/160\/1\/4\/24195041\/kfx154.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T14:23:00Z","timestamp":1569939780000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/160\/1\/4\/4055580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,28]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,7,28]]},"published-print":{"date-parts":[[2017,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfx154","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,11]]},"published":{"date-parts":[[2017,7,28]]}}}