{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:02:53Z","timestamp":1781672573398,"version":"3.54.5"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21-ES024859"],"award-info":[{"award-number":["R21-ES024859"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["P30CA023108"],"award-info":[{"award-number":["P30CA023108"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["RD83544201"],"award-info":[{"award-number":["RD83544201"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Rochester Environmental Health Science Center","award":["P30 ES001247"],"award-info":[{"award-number":["P30 ES001247"]}]},{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","award":["P42 ES007373, 1UG3OD023275-01 and P01ES022832"],"award-info":[{"award-number":["P42 ES007373, 1UG3OD023275-01 and P01ES022832"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"DOI":"10.1093\/toxsci\/kfx226","type":"journal-article","created":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T15:20:21Z","timestamp":1508944821000},"page":"443-453","source":"Crossref","is-referenced-by-count":35,"title":["Editor\u2019s Highlight: Variation in Methylmercury Metabolism and Elimination Status in Humans Following Fish Consumption"],"prefix":"10.1093","volume":"161","author":[{"given":"Samuel W","family":"Caito","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P","family":"Jackson","sequence":"additional","affiliation":[{"name":"Trace Element Analysis Laboratory, Dartmouth College, Hanover, New Hampshire 03755"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Punshon","sequence":"additional","affiliation":[{"name":"Trace Element Analysis Laboratory, Dartmouth College, Hanover, New Hampshire 03755"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Scrimale","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Grier","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanzy M","family":"Love","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"},{"name":"Department of Biostatistics and Computational Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene E","family":"Watson","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"},{"name":"Eastman Institute for Oral Health"},{"name":"Department of Pharmacology and Physiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"van Wijngaarden","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"},{"name":"Eastman Institute for Oral Health"},{"name":"Department of Pediatrics"},{"name":"Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D","family":"Rand","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"key\n\t\t\t\t20180328153637_kfx226-B1","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1080\/00039896.1969.10666872","article-title":"Metabolism of methyl mercury (203Hg) compounds in man","volume":"19","author":"Aberg","year":"1969","journal-title":"Archives of Environmental Health"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/00039896.1974.10666505","article-title":"Variation of biological half-life f methylmercury in man","volume":"28","author":"Al-Shahristani","year":"1974","journal-title":"Arch. Environ. Health"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.radphyschem.2013.06.004","article-title":"Determination of arsenic and mercury level in scalp hair from a selected population in Penang, Malaysia using XRF technique","volume":"91","author":"Ali Aldroobi","year":"2013","journal-title":"Radiat. Phys. Chem."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1001\/archpedi.1979.02130020064013","article-title":"Prenatal methylmercury poisoning. Clinical observations over five years","volume":"133","author":"Amin-Zaki","year":"1979","journal-title":"Am. J. Dis. Child."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/00039896.1972.10666141","article-title":"Studies on humans exposed to methyl mercury through fish consumption","volume":"25","author":"Birke","year":"1972","journal-title":"Arch. Environ. Health"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B6","doi-asserted-by":"crossref","first-page":"169.","DOI":"10.3390\/ijerph14020169","article-title":"A review of mercury bioavailability in humans and fish","volume":"14","author":"Bradley","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B7","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuro.2007.02.009","article-title":"The biological monitoring of prenatal exposure to methylmercury","volume":"28","author":"Cernichiari","year":"2007","journal-title":"Neurotoxicology"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B8","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.envint.2016.05.027","article-title":"Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study","volume":"94","author":"Engstrom","year":"2016","journal-title":"Environ. Int."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B9","author":"EPA","year":"2001"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B10","author":"EPA","year":"2017"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B11","author":"FDA","year":"1991\u20132010"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408449509089885","article-title":"Minamata disease: Methylmercury poisoning in Japan caused by environmental pollution","volume":"25","author":"Harada","year":"1995","journal-title":"Crit. Rev. Toxicol."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0379-0738(93)90255-9","article-title":"Anatomy and physiology of hair","volume":"63","author":"Harkey","year":"1993","journal-title":"Forens. Sci. Int."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B14","author":"IAEA","year":"2017"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1080\/00039890009603384","article-title":"Excretion of methyl mercury in human feces","volume":"55","author":"Ishihara","year":"2000","journal-title":"Archives of Environmental Health"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B16","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1039\/c1cs15021a","article-title":"Hair analysis as a biomonitor for toxicology, disease and health status","volume":"40","author":"Kempson","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/00039896.1980.10667458","article-title":"The relationship between blood levels and dose of methylmercury in man","volume":"35","author":"Kershaw","year":"1980","journal-title":"Arch. Environ. Health"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B18","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1039\/b406733a","article-title":"Direct detection of mercury in single human hair strands by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)","volume":"19","author":"Legrand","year":"2004","journal-title":"J. Anal. Atom. Spectrom."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B19","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1021\/es061823c","article-title":"Analysis of mercury in sequential micrometer segments of single hair strands of fish-eaters","volume":"41","author":"Legrand","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B20","doi-asserted-by":"crossref","first-page":"103.","DOI":"10.12952\/journal.elementa.000103","article-title":"Insights from mercury stable isotopes into factors affecting the internal body burden of methylmercury in frequent fish consumers","volume":"4","author":"Li","year":"2016","journal-title":"Elem. Sci. Anth"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.envres.2007.07.003","article-title":"Scalp hair as a biomarker in environmental and occupational mercury exposed populations: Suitable or not?","volume":"107","author":"Li","year":"2008","journal-title":"Environ. Res."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B22","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/BF01780983","article-title":"Demethylation of methylmercury during inorganic determination by teh Magos cold vapor atomic absorption technique","volume":"348","author":"Lind","year":"1994","journal-title":"Fresnius J. Anal. Chem."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.envint.2017.04.013","article-title":"CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment","volume":"105","author":"Llop","year":"2017","journal-title":"Environ. Int."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B24","first-page":"966","article-title":"Atomic absorption determination of total, inorganic, and organic mercury in blood","volume":"55","author":"Magos","year":"1972","journal-title":"Journal - Association of Official Analytical Chemists"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B25","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1001\/archneur.1987.00520220023010","article-title":"Fetal methylmercury poisoning. Relationship between concentration in single strands of maternal hair and child effects","volume":"44","author":"Marsh","year":"1987","journal-title":"Arch. Neurol"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B26","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1080\/15287394.2012.695232","article-title":"Evaluation of glutathione S-transferase GSTM1 and GSTT1 polymorphisms and methylmercury metabolism in an exposed Amazon population","volume":"75","author":"Mazzaron Barcelos","year":"2012","journal-title":"J. Toxicol. Environ. Health"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B27","first-page":"116","article-title":"Elimination of 203Hg-methylmercury in man","volume":"3","author":"Miettinen","year":"1971","journal-title":"Ann. Clin. Res."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B28","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1749-6632.1951.tb31957.x","article-title":"Regeneration and rate of growth of hairs in man","volume":"53","author":"Myers","year":"1951","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B29","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1080\/00039896.1971.10665903","article-title":"Intestinal transport of 203Hg-labeled methyl mercury chloride. Role of biotransformation in rats","volume":"22","author":"Norseth","year":"1971","journal-title":"Arch. Environ. Health"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B30","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/aje\/kwn034","article-title":"Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort","volume":"167","author":"Oken","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/00039896.1980.10667486","article-title":"Interrelationships of blood and hair mercury concentrations in a North American population exposed to methylmercury","volume":"35","author":"Phelps","year":"1980","journal-title":"Arch. Environ. Health"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/toxsci\/kfv241","article-title":"Methods for individualized determination of methylmercury elimination rate and de-methylation status in humans following fish consumption","volume":"149","author":"Rand","year":"2016","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0048-9697(02)00463-1","article-title":"Application of double focusing sector field ICP-MS for multielemental characterization of human hair and nails. Part III. Direct analysis by laser ablation","volume":"305","author":"Rodushkin","year":"2003","journal-title":"Sci. Total Environ."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B34","first-page":"79","article-title":"The effect of the gastrointestinal flora on tissue content of mercury and organomercurial neurotoxicity in rats given methylmercuric chloride","volume":"8","author":"Rowland","year":"1980","journal-title":"Dev. Toxicol. Environ. Sci"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B35","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/bst0050423","article-title":"The effect of elimination of the gastrointestinal flora on the accumulation of methylmercuric chloride by the rat","volume":"5","author":"Rowland","year":"1977","journal-title":"Biochem. Soc. Trans."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/00498257809060381","article-title":"Metabolism of methylmercuric chloride by the gastro-intestinal flora of the rat","volume":"8","author":"Rowland","year":"1978","journal-title":"Xenobiotica"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B37","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1080\/00039896.1984.10545872","article-title":"Effects of diet on mercury metabolism and excretion in mice given methylmercury: Role of gut flora","volume":"39","author":"Rowland","year":"1984","journal-title":"Arch. Environ. Health"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/096032718400300205","article-title":"Elevation of mercury in human blood from controlled chronic ingestion of methylmercury in fish","volume":"3","author":"Sherlock","year":"1984","journal-title":"Hum. Toxicol."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B39","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/taap.1994.1204","article-title":"The kinetics of intravenously administered methyl mercury in man","volume":"128","author":"Smith","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B40","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s00216-005-3283-4","article-title":"Time-resolved monitoring of heavy-metal intoxication in single hair by laser ablation ICP-DRCMS","volume":"383","author":"Stadlbauer","year":"2005","journal-title":"Anal. Bioanal. Chem."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B41","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.3390\/nu7032001","article-title":"Fish intake during pregnancy and foetal neurodevelopment\u2013a systematic review of the evidence","volume":"7","author":"Starling","year":"2015","journal-title":"Nutrients"},{"key":"key\n\t\t\t\t20180328153637_kfx226-B42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/toxsci\/kfx033","article-title":"Editor\u2019s highlight: Glutathione S-transferase activity moderates methylmercury toxicity during development in Drosophila","volume":"157","author":"Vorojeikina","year":"2017","journal-title":"Toxicol. Sci."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2131\/jts.37.123","article-title":"Hair-to-blood ratio and biological half-life of mercury: Experimental study of methylmercury exposure through fish consumption in humans","volume":"37","author":"Yaginuma-Sakurai","year":"2012","journal-title":"J. Toxicol. Sci."},{"key":"key\n\t\t\t\t20180328153637_kfx226-B44","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/jat.1307","article-title":"Validity of methyl mercury hair analysis: Mercury monitoring in human scalp\/nude mouse model","volume":"28","author":"Zareba","year":"2008","journal-title":"J. Appl. Toxicol."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/161\/2\/443\/24195410\/kfx226.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T21:49:04Z","timestamp":1522273744000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/161\/2\/443\/4627839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,14]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,11,14]]},"published-print":{"date-parts":[[2018,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfx226","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,2]]},"published":{"date-parts":[[2017,11,14]]}}}