{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:12:54Z","timestamp":1791443574059,"version":"4.3.3"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"DOI":"10.1093\/toxsci\/kfx265","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T20:14:49Z","timestamp":1513196089000},"page":"429-438","source":"Crossref","is-referenced-by-count":26,"title":["Determination of Protein Haptenation by Chemical Sensitizers Within the Complexity of the Human Skin Proteome"],"prefix":"10.1093","volume":"162","author":[{"given":"Erika","family":"Parkinson","sequence":"first","affiliation":[{"name":"Centre for Biological Sciences"},{"name":"Centre for Proteomic Research, Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Aleksic","sequence":"additional","affiliation":[{"name":"Safety & Environmental Assurance Centre, Unilever, Colworth Science Park, Sharnbrook MK44 1LQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Cubberley","sequence":"additional","affiliation":[{"name":"Safety & Environmental Assurance Centre, Unilever, Colworth Science Park, Sharnbrook MK44 1LQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gushinder","family":"Kaur-Atwal","sequence":"additional","affiliation":[{"name":"Waters Corporation, Wilmslow SK9 4AX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes P C","family":"Vissers","sequence":"additional","affiliation":[{"name":"Waters Corporation, Wilmslow SK9 4AX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Skipp","sequence":"additional","affiliation":[{"name":"Centre for Biological Sciences"},{"name":"Centre for Proteomic Research, Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"key\n\t\t\t\t20180326085314_kfx265-B1","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.tiv.2010.07.005","article-title":"Identifying and characterizing chemical skin sensitizers without animal testing: \u2018research and method development program","volume":"24","author":"Aeby","year":"2010","journal-title":"Toxicol. In Vitro"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1159\/000068288","article-title":"Reactivity of contact allergenic haptens to amino acid residues in a model carrier peptide, and characterization of formed peptide-hapten adducts","volume":"16","author":"Ahlfors","year":"2003","journal-title":"Skin Pharmacol. Appl. Skin Physiol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B3","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.tiv.2007.01.008","article-title":"Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein","volume":"21","author":"Aleksic","year":"2007","journal-title":"Toxicol. In Vitro"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B4","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.tiv.2008.03.006","article-title":"Mass spectrometric identification of covalent adducts of the skin allergen 2, 4-dinitro-1-chlorobenzene and model skin proteins","volume":"22","author":"Aleksic","year":"2008","journal-title":"Toxicol. In Vitro"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/toxsci\/kfp030","article-title":"Reactivity profiling: Covalent modification of single nucleophile peptides for skin sensitization risk assessment","volume":"108","author":"Aleksic","year":"2009","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1021\/tx0256634","article-title":"Studies of chemical selectivity of hapten, reactivity, and skin sensitization potency. 3. Synthesis and studies on the reactivity toward model nucleophiles of the 13C-labeled skin sensitizers, 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI)","volume":"16","author":"Alvarez-Sanchez","year":"2003","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bmcl.2003.11.002","article-title":"Covalent binding of the 13C-labeled skin sensitizers 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) to a model peptide and glutathione","volume":"14","author":"Alvarez-Sanchez","year":"2004","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B8","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1021\/tx049935+","article-title":"Effect of glutathione on the covalent binding of the 13C-labeled skin sensitizer 5-chloro-2-methylisothiazol-3-one to human serum albumin: Identification of adducts by nuclear magnetic resonance, matrix-assisted laser desorption\/ionization mass spectrometry, and nanoelectrospray tandem mass spectrometry","volume":"17","author":"Alvarez-Sanchez","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0300-483X(95)03132-Y","article-title":"Structure activity relationships in skin sensitization using the murine local lymph node assay","volume":"103","author":"Ashby","year":"1995","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0536.1995.tb00748.x","article-title":"The chemistry of contact allergy: Why is a molecule allergenic?","volume":"32","author":"Basketter","year":"1995","journal-title":"Contact Dermatitis"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-0536.1997.tb00421.x","article-title":"Dinitrohalobenzenes: Evaluation of relative skin sensitization potential using the local lymph node assay","volume":"36","author":"Basketter","year":"1997","journal-title":"Contact Dermatitis"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B12","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0165-6147(00)01704-1","article-title":"Measurement of allergenic potency using the local lymph node assay","volume":"22","author":"Basketter","year":"2001","journal-title":"Trends Pharmacol. Sci"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B13","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/y59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B14","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.4049\/jimmunol.155.5.2670","article-title":"Heterogenous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals","volume":"155","author":"Brander","year":"1995","journal-title":"J. Immunol"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B15","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/jat.3165","article-title":"Adverse Outcome Pathways can drive non-animal approaches for safety assessment","volume":"35","author":"Burden","year":"2015","journal-title":"J. Appl. Toxicol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B16","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1021\/tx800465m","article-title":"Protein modification by acrolein: Formation and stability of cysteine adducts","volume":"22","author":"Cai","year":"2009","journal-title":"Chem. Res. Toxicol"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B17","doi-asserted-by":"crossref","first-page":"11.","DOI":"10.1155\/2011\/839682","article-title":"Haptenation: Chemical reactivity and protein binding","volume":"2011","author":"Chipinda","year":"2011","journal-title":"J. Allergy"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B18","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1074\/mcp.M800070-MCP200","article-title":"Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal","volume":"8","author":"Codreanu","year":"2009","journal-title":"Mol. Cell Proteomics"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B19","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/1615-9861(200107)1:7<829::AID-PROT829>3.0.CO;2-R","article-title":"Identification of protein carbonyls after two-dimensional electrophoresis","volume":"1","author":"Conrad","year":"2001","journal-title":"Proteomics"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B20","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/toxsci\/kfq209","article-title":"Tracking human contact allergens: From mass spectrometric indetification of peptide-bound reactive small chemicals to chemical-specific na\u00efve human T-cell priming","volume":"117","author":"Dietz","year":"2010","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1021\/tx0341456","article-title":"Protein binding and metabolism influence the relative skin sensitization potential of cinnamic compounds","volume":"17","author":"Elahi","year":"2004","journal-title":"Chem. Res. Toxicol"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B22","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1021\/tx4000655","article-title":"Predicting Skin Sensitization Potency for Michael Acceptors in the LLNA Using Quantum Mechanics Calculations","volume":"26","author":"Enoch","year":"2013","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B23","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0040-4020(76)87015-9","article-title":"The reaction of cysteine with \u03b1,\u03b2-unsaturated aldehydes","volume":"32","author":"Esterbauer","year":"1976","journal-title":"Tetrahedon"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00204-016-1842-4","article-title":"State of the art in non-animal approaches for skin sensitization testing: From individual test methods towards testing strategies","volume":"90","author":"Ezendam","year":"2016","journal-title":"Arch. Toxicol"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/toxsci\/kfh213","article-title":"Development of a peptide reactivity assay for screening contact allergens","volume":"81","author":"Gerberick","year":"2004","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B26","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/toxsci\/kfm064","article-title":"Quantification of chemical peptide reactivity for screening contact allergens: A classification tree model approach","volume":"97","author":"Gerberick","year":"2007","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B27","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4049\/jimmunol.106.2.431","article-title":"The effect of physical and chemical properties of the sensitizing substance on the induction and elicitation of delayed contact sensitivity","volume":"106","author":"Godfrey","year":"1971","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B28","doi-asserted-by":"crossref","first-page":"7968","DOI":"10.1073\/pnas.0602816103","article-title":"Differentiation of proteins based on characteristic patterns of association and denaturation in solutions of SDS","volume":"103","author":"Gudiksen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B29","doi-asserted-by":"crossref","first-page":"31768","DOI":"10.1074\/jbc.M503346200","article-title":"Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation","volume":"280","author":"Hong","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B30","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1021\/tx049688+","article-title":"Selective haptenation of cellular or extracellular protein by chemical allergens: Association with cytokine polarization","volume":"18","author":"Hopkins","year":"2005","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B31","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1021\/acs.jmedchem.6b00788","article-title":"Covalent Modifiers: A chemical perspective on the reactivity of \u03b1,\u03b2-unsaturated carbonyls with thiols via hetero-Michael Addition reactions","volume":"60","author":"Jackson","year":"2017","journal-title":"J. Med. Chem"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1021\/ar900286y","article-title":"Systems analysis of protein modification and cellular responses induced by electrophile stress","volume":"43","author":"Jacobs","year":"2010","journal-title":"Accounts Chem. Res."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B33","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/jat.2869","article-title":"Bayesian integrated testing strategy to assess skin sensitization potency: From theory to practice","volume":"33","author":"Jaworska","year":"2013","journal-title":"J. Appl. Toxicol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B34","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/jid.2009.271","article-title":"Characterisation of p-phenylenediamine-albumin binding sites and T-cell repsonses to hapten-modified protein","volume":"130","author":"Jenkinson","year":"2010","journal-title":"J. Invest. Dermatol"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1021\/tx7002239","article-title":"Allergic Contact Dermatitis - Formation, structural requirements and reactivity of skin sensitizers","volume":"21","author":"Karlberg","year":"2008","journal-title":"Chem. Res. Toxicol"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B36","doi-asserted-by":"crossref","first-page":"S238","DOI":"10.1093\/toxsci\/kfq346","article-title":"Chemical allergy: Translating biology into hazard characterization","volume":"120","author":"Kimber","year":"2011","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S1081-1206(10)61645-6","article-title":"What makes a chemical an allergen?","volume":"90","author":"Kimber","year":"2003","journal-title":"Ann. Allergy Asthma Immunol"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cod.12789","article-title":"Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis","volume":"77","author":"Koppes","year":"2017","journal-title":"Contact Dermatits"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B39","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.61.5.643","article-title":"Studies on the sensitization of animals with simple chemical compounds","volume":"61","author":"Landsteiner","year":"1935","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B40","first-page":"234","article-title":"The chemistry of skin allergy","volume":"23(Suppl)","author":"Lepoittevin","year":"2006","journal-title":"Altex"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B41","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0300-483X(95)03279-O","article-title":"Further evaluation of the local lymph node assay in the final phase of an international collaborative trial","volume":"108","author":"Loveless","year":"1996","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B42","doi-asserted-by":"crossref","first-page":"473","DOI":"10.14573\/altex.2013.4.473","article-title":"From pathways to people: Applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment","volume":"30","author":"MacKay","year":"2013","journal-title":"Altex"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B43","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-0536.1977.tb03581.x","article-title":"Mechanism of cinnamaldehyde sensitization","volume":"3","author":"Majeti","year":"1977","journal-title":"Contact Dermatitis"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B44","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/ACI.0000000000000142","article-title":"Immunological mechanisms in allergic contact dermatitis","volume":"15","author":"Martin","year":"2015","journal-title":"Curr. Opin. Aleergy Clin. Immunol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B45","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1177\/026119290803600510","article-title":"Application of a systems biology approach to skin allergy risk assessment","volume":"36","author":"Maxwell","year":"2008","journal-title":"Altern. Lab. Anim."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tiv.2013.10.013","article-title":"Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment","volume":"28","author":"Maxwell","year":"2014","journal-title":"Toxicol. In Vitro"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B47","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.neuroscience.2007.04.003","article-title":"Acrolein induces selective protein carbonylation in synaptosomes","volume":"147","author":"Mello","year":"2007","journal-title":"Neuroscience"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B48","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/toxsci\/kfn194","article-title":"LC-MS-based characterization of the peptide reactivity of chemicals to improve the in vitro prediction of the skin sensitization potential","volume":"106","author":"Natsch","year":"2008","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B49","author":"OECD","year":"2012"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B50","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/toxsci\/kfu168","article-title":"Stable isotope labeling method for the investigation of protein haptenation by electrophilic skin sensitizers","volume":"142","author":"Parkinson","year":"2014","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B51","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/10629360701427872","article-title":"An evaluation of selected global (Q)SARs\/expert systems for the prediction of skin sensitisation potential","volume":"18","author":"Patlewicz","year":"2007","journal-title":"SAR QSAR. Environ. Res"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B52","doi-asserted-by":"crossref","first-page":"7576","DOI":"10.4049\/jimmunol.0901064","article-title":"The cutaneous biochemical redox barrier: A component of the innate immune defenses against sensitization by highly reactive environmental xenobiotics","volume":"183","author":"Pickard","year":"2009","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B53","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1016\/j.febslet.2013.10.006","article-title":"Protein alkylation by the \u03b1,\u03b2-unsaturated aldehyde acrolein. A reversible mechanism of electrophile signaling?","volume":"587","author":"Randall","year":"2013","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B54","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/jat.1289","article-title":"Determinants of skin sensitisation potential","volume":"28","author":"Roberts","year":"2008","journal-title":"J. Appl. Toxicol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B55","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1021\/tx060121y","article-title":"Electrophilic chemistry related to skin sensitization. reaction mechanistic applicability domain classification for a published data set of 106 chemicals tested in the mouse local lymph node assay","volume":"20","author":"Roberts","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B56","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1021\/tx800431x","article-title":"High throughput kinetic profiling approach for covalent binding to peptides: Application to skin sensitization potency of Michael acceptor electrophiles","volume":"22","author":"Roberts","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B57","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1039\/C5TX00246J","article-title":"Mechanistic understanding of molecular initiating events (MIEs) using NMR spectroscopy","volume":"5","author":"Sanderson","year":"2016","journal-title":"Toxicol. Res."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B58","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.redox.2015.11.013","article-title":"Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice","volume":"7","author":"Shearn","year":"2016","journal-title":"Redox. Biol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B59","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1074\/mcp.M500230-MCP200","article-title":"Absolute quantification of proteins by LCMSE: A virtue of parallel MS acquisition","volume":"5","author":"Silva","year":"2006","journal-title":"Mol. Cell Proteomics"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B60","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/jid.2010.422","article-title":"Caged fluorescent haptens reveal the generation of cryptic epitopes in allergic contact dermatitis","volume":"131","author":"Simonsson","year":"2011","journal-title":"J. Investig. Dermatol"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B61","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B62","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1016\/j.jprot.2011.05.039","article-title":"Proteomic profiling of acrolein adducts in human lung epithelial cells","volume":"74","author":"Spiess","year":"2011","journal-title":"J. Proteomics"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B63","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/jat.3281","article-title":"Integrated decision strategies for skin sensitization hazard","volume":"36","author":"Strickland","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B64","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1600-0536.2007.01220.x","article-title":"The epidemiology of contact allergy in the general population\u2013prevalence and main findings","volume":"57","author":"Thyssen","year":"2007","journal-title":"Contact Dermatitis"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B65","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tox.2013.08.011","article-title":"The adverse outcome pathway concept: A pragmatic tool in toxicology","volume":"312","author":"Vinken","year":"2013","journal-title":"Toxicology"},{"key":"key\n\t\t\t\t20180326085314_kfx265-B66","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0003-2697(88)90383-1","article-title":"Investigation of the bicinchoninic acid protein assay - Identification of the groups responsible for color formation","volume":"175","author":"Wiechelman","year":"1988","journal-title":"Anal. Biochem."},{"key":"key\n\t\t\t\t20180326085314_kfx265-B67","first-page":"307","article-title":"The reaction of sulfhydryl groups with carbonyl compounds","volume":"35","author":"Wlodek","year":"1988","journal-title":"Acta Biochim. Pol."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/162\/2\/429\/24474012\/kfx265.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T18:09:31Z","timestamp":1719684571000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/162\/2\/429\/4756478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,18]]},"references-count":67,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,12,18]]},"published-print":{"date-parts":[[2018,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfx265","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,4]]},"published":{"date-parts":[[2017,12,18]]}}}