{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:25:38Z","timestamp":1782743138417,"version":"3.54.5"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"Health and Labour Sciences Research"},{"name":"Ministry of Health, Labour and Welfare of Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"DOI":"10.1093\/toxsci\/kfy151","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T11:15:28Z","timestamp":1530011728000},"page":"420-430","source":"Crossref","is-referenced-by-count":11,"title":["Mechanisms Underlying Exacerbation of Osmotic Nephrosis Caused by Pre-existing Kidney Injury"],"prefix":"10.1093","volume":"165","author":[{"given":"Kohei","family":"Matsushita","sequence":"first","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Takasu","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Ishii","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Kijima","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Umemura","sequence":"additional","affiliation":[{"name":"Division of Pathology, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, 210-9501, Japan"},{"name":"Laboratory of Animal Pathology, Faculty of Animal Health Technology, Yamazaki University of Animal Health Technology, 4-7-2 Minami Osawa, Hachioji, Tokyo 192-0364, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"key\n\t\t\t\t20180925085236_kfy151-B1","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/cphy.c110041","article-title":"Pathophysiology of acute kidney injury","volume":"2","author":"Basile","year":"2012","journal-title":"Compr. Physiol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B2","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1073\/pnas.1316177111","article-title":"Origin of regenerating tubular cells after acute kidney injury","volume":"111","author":"Berger","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"key\n\t\t\t\t20180925085236_kfy151-B3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1053\/j.ajkd.2010.10.057","article-title":"Dextran removal by plasmapheresis in a kidney-pancreas transplant recipient with dextran 40-induced osmotic nephrosis","volume":"57","author":"Bhatt","year":"2011","journal-title":"Am. J. Kidney Dis"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B4","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1053\/j.ajkd.2007.10.044","article-title":"Osmotic nephrosis: Acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutes","volume":"51","author":"Dickenmann","year":"2008","journal-title":"Am. J. Kidney Dis"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B5","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1053\/j.ajkd.2010.10.044","article-title":"Acute kidney injury due to osmotic nephrosis following intraoperative placement of an intraperitoneal antiadhesive barrier","volume":"57","author":"Economidou","year":"2011","journal-title":"Am. J. Kidney Dis"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B6","doi-asserted-by":"crossref","first-page":"i2","DOI":"10.1093\/ndt\/gfl213","article-title":"The clinical and renal consequences of contrast-induced nephropathy","volume":"21","author":"Finn","year":"2006","journal-title":"Nephrol. Dial. Transplant"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B7","doi-asserted-by":"crossref","first-page":"14S","DOI":"10.1177\/0192623312438736","article-title":"Proliferative and nonproliferative lesions of the rat and mouse urinary system","volume":"40","author":"Frazier","year":"2012","journal-title":"Toxicol. Pathol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.addr.2017.01.005","article-title":"Xenobiotic transporters and kidney injury","volume":"116","author":"George","year":"2017","journal-title":"Adv. Drug Deliv. Rev"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/BF02889140","article-title":"Effect of mannitol, dextran (macrodex), allopurinol, and methylprednisolone on the morphology of the proximal tubule of the rat kidney made ischemic in vivo","volume":"23","author":"Glaumann","year":"1977","journal-title":"Virchows Arch. B Cell Pathol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B100","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/jat.3155","article-title":"Safety data on 19 vehicles for use in 1 month oral rodent pre-clinical studies: administration of hydroxypropyl-ss-cyclodextrin causes renal toxicity","volume":"36","author":"Healing","year":"2016","journal-title":"J. Appl. Toxicol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B10","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000399756","article-title":"Cytochemical studies of acute tubular necrosis caused by simultaneous administration of dextran and kanamycin","volume":"6","author":"Hirata","year":"1977","journal-title":"Contrib. Nephrol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B11","doi-asserted-by":"crossref","first-page":"990.","DOI":"10.1681\/ASN.2015030286","article-title":"Targeting endogenous repair pathways after AKI","volume":"27","author":"Humphreys","year":"2016","journal-title":"J. Am. Soc. Nephrol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B12","first-page":"215","article-title":"Experimental study of drug-induced acute renal failure. Recovery after renal impairment caused by the administration of low molecular weight dextran and kanamycin in water-deprived rats","volume":"34","author":"Ishikawa","year":"1988","journal-title":"Hinyokika Kiyo"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.etp.2012.06.003","article-title":"A modified model of gentamicin induced renal failure in rats: Toxicological effects of the iodinated X-ray contrast media ioversol and potential usefulness for toxicological evaluation of iodinated X-ray contrast media","volume":"65","author":"Jensen","year":"2013","journal-title":"Exp. Toxicol. Pathol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000360671","article-title":"Tubular regeneration: When can the kidney regenerate from injury and what turns failure into success?","volume":"126","author":"Johansson","year":"2014","journal-title":"Nephron Exp. Nephrol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B15","doi-asserted-by":"crossref","first-page":"e25679.","DOI":"10.1371\/journal.pone.0025679","article-title":"Gene expression analysis reveals the cell cycle and kinetochore genes participating in ischemia reperfusion injury and early development in kidney","volume":"6","author":"Kim","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/toxsci\/kfp041","article-title":"Mono-(2-ethylhexyl) phthalate targets glycogen debranching enzyme and affects glycogen metabolism in rat testis","volume":"109","author":"Kuramori","year":"2009","journal-title":"Toxicol. Sci"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B17","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00467-013-2669-3","article-title":"Controversies on the origin of proliferating epithelial cells after kidney injury","volume":"29","author":"Kusaba","year":"2014","journal-title":"Pediatr. Nephrol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B18","doi-asserted-by":"crossref","first-page":"e59745.","DOI":"10.1371\/journal.pone.0059745","article-title":"Enzyme-synthesized highly branched maltodextrins have slow glucose generation at the mucosal alpha-glucosidase level and are slowly digestible in vivo","volume":"8","author":"Lee","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B19","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1681\/ASN.2012121169","article-title":"The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice","volume":"24","author":"Linkermann","year":"2013","journal-title":"J. Am. Soc. Nephrol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B20","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1155\/2015\/964849","article-title":"Diverse cell populations involved in regeneration of renal tubular epithelium following acute kidney injury","volume":"2015","author":"Maeshima","year":"2015","journal-title":"Stem Cells Int"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.etp.2014.09.006","article-title":"A medium-term gpt delta rat model as an in vivo system for analysis of renal carcinogenesis and the underlying mode of action","volume":"67","author":"Matsushita","year":"2015","journal-title":"Exp. Toxicol. Pathol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B22","first-page":"421","article-title":"Light and electron microscopic changes in proximal tubules of rats after administration of glucose, mannitol, sucrose, or dextran","volume":"11","author":"Maunsbach","year":"1962","journal-title":"Lab. Invest"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B23","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0278-6915(85)90109-7","article-title":"Light- and electron-microscopic evaluation of renal tubular cell vacuolation induced by administration of nitrilotriacetate or sucrose","volume":"23","author":"Merski","year":"1985","journal-title":"Food Chem. Toxicol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B24","first-page":"341","article-title":"Dextran: Structure and synthesis","volume":"15","author":"Neely","year":"1960","journal-title":"Adv. Carbohydr. Chem"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B25","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3109\/0886022X.2014.926758","article-title":"Osmotic nephrosis with mannitol: Review article","volume":"36","author":"Nomani","year":"2014","journal-title":"Ren. Fail"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/ccd.21207","article-title":"Contrast-induced nephropathy","volume":"71","author":"Pucelikova","year":"2008","journal-title":"Catheter. Cardiovasc. Intervent"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1177\/019262339702500205","article-title":"An ultrastructural histochemistry and light microscopy study of the early development of renal proximal tubular vacuolation after a single administration of the contrast enhancement medium \u201cIotrolan\u201d","volume":"25","author":"Rees","year":"1997","journal-title":"Toxicol. Pathol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B28","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/jon.12356","article-title":"Preclinical studies of a kidney safe iodinated contrast agent","volume":"26","author":"Rowe","year":"2016","journal-title":"J. Neuroimaging"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B29","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1097\/00004424-199406001-00037","article-title":"Effects of iotrolan, iopamidol, and iopromide in rats with and without experimental nephropathy","volume":"29","author":"Uchimoto","year":"1994","journal-title":"Invest. Radiol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/jb\/mvj129","article-title":"Activation of 4-alpha-glucanotransferase activity of porcine liver glycogen debranching enzyme with cyclodextrins","volume":"140","author":"Watanabe","year":"2006","journal-title":"J. Biochem"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B31","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s00134-013-3156-9","article-title":"Accumulation of hydroxyethyl starch in human and animal tissues: A systematic review","volume":"40","author":"Wiedermann","year":"2014","journal-title":"Intensive Care Med"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.18388\/abp.2007_3262","article-title":"A novel alpha-glucosidase from the moss Scopelophila cataractae","volume":"54","author":"Yamasaki","year":"2007","journal-title":"Acta Biochim. Pol"},{"key":"key\n\t\t\t\t20180925085236_kfy151-B33","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/labinvest.2015.153","article-title":"Wnt\/beta-catenin signaling in kidney injury and repair: A double-edged sword","volume":"96","author":"Zhou","year":"2016","journal-title":"Lab. Invest"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/165\/2\/420\/25818661\/kfy151.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T11:22:48Z","timestamp":1661512968000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/165\/2\/420\/5045877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,27]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,6,27]]},"published-print":{"date-parts":[[2018,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfy151","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,10]]},"published":{"date-parts":[[2018,6,27]]}}}