{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T13:33:17Z","timestamp":1785504797627,"version":"3.56.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB01020300"],"award-info":[{"award-number":["XDB01020300"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21836005, 21621064, 21377158, 21577149, and 21477139"],"award-info":[{"award-number":["21836005, 21621064, 21377158, 21577149, and 21477139"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1093\/toxsci\/kfy307","type":"journal-article","created":{"date-parts":[[2018,12,16]],"date-time":"2018-12-16T07:07:00Z","timestamp":1544944020000},"page":"339-348","source":"Crossref","is-referenced-by-count":9,"title":["The Critical Role of X Chromosome-Linked Inhibitor of Apoptosis (XIAP) in Differential Synergism Induced by Pentachlorophenol and Copper-1,10-Phenanthroline Complex in Normal and Cancer Liver Cells"],"prefix":"10.1093","volume":"168","author":[{"given":"Zhi-Guo","family":"Sheng","sequence":"first","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Shen","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Mei","family":"Fan","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Juan","family":"Chao","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xiang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Xinjiang Normal University, Urumqi, Xinjiang 830054, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben-Zhan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China"},{"name":"Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B1","author":"Albert","year":"1985"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.cellbio.15.1.269","article-title":"Biochemical pathways of caspase activation during apoptosis","volume":"15","author":"Budihardjo","year":"1999","journal-title":"Annu. Rev. Cell Dev. Biol"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B3","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s001289900184","article-title":"Effects of copper-chrome-arsenate (CCA) components on PCP degradation by Arthrobacter strain ATCC 33790","volume":"57","author":"Edgehill","year":"1996","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B4","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1002\/tox.22197","article-title":"Different modes of synergistic toxicities between metam\/copper (II) and metam\/zinc (II) in HepG2 cells: Apoptosis vs. necrosis","volume":"31","author":"Fan","year":"2016","journal-title":"Environ. Toxicol"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B5","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1021\/acs.est.6b04664","article-title":"Mechanism of intrinsic chemiluminescence production from the degradation of persistent chlorinated phenols by the Fenton system: A structure-activity relationship study and the critical role of quinoid and semiquinone radical intermediates","volume":"51","author":"Gao","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B6","doi-asserted-by":"crossref","first-page":"33159.","DOI":"10.1038\/srep33159","article-title":"Why does 2,3,5,6-tetrachlorophenol generate the strongest intrinsic chemiluminescence among all nineteen chlorophenolic persistent organic pollutants during environmentally-friendly advanced oxidation process?","volume":"6","author":"Gao","year":"2016","journal-title":"Sci. Rep."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B7","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S1470-2045(16)30513-7","article-title":"Carcinogenicity of pentachlorophenol and some related compounds","volume":"17","author":"Guyton","year":"2016","journal-title":"Lancet Oncol."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.freeradbiomed.2008.04.004","article-title":"Cancer chemoprevention: A radical perspective","volume":"45","author":"Hail","year":"2008","journal-title":"Free Radic. Biol Med."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B9","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1021\/tx500486z","article-title":"Molecular mechanism of metal-independent decomposition of organic hydroperoxides by halogenated quinoid carcinogens and the potential biological implications","volume":"28","author":"Huang","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B10","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/35030140","article-title":"Superoxide dismutase as a target for the selective killing of cancer cells","volume":"407","author":"Huang","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B11","first-page":"371","article-title":"Pentachlorophenol","volume":"53","author":"IARC","year":"1991","journal-title":"IARC Monogr. Eval. Carcinog. Risks Hum."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0168-8278(97)80016-5","article-title":"Reducing environment protects sinusoidal lymphocytes isolated from normal human liver from apoptosis","volume":"26","author":"Kinoshita","year":"1997","journal-title":"J. Hepatol."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B13","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1007\/s00216-010-3796-3","article-title":"Detection and mechanistic investigation of halogenated benzoquinone induced DNA damage by photoelectrochemical DNA sensor","volume":"397","author":"Jia","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1054\/mehy.1999.0982","article-title":"A threshold concept for cancer therapy","volume":"55","author":"Kong","year":"2000","journal-title":"Med. Hypotheses"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B15","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1023\/A:1026465926478","article-title":"Life and death decisions: The role of the IAPs in modulating programmed cell death","volume":"2","author":"Liston","year":"1997","journal-title":"Apoptosis"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1191\/0960327102ht213oa","article-title":"Reactive oxygen species as double-edged swords in cellular processes: Low-dose cell signaling versus high-dose toxicity","volume":"21","author":"Martin","year":"2002","journal-title":"Hum. Exp. Toxicol."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.abb.2007.01.033","article-title":"XIAP: Cell death regulation meets copper homeostasis","volume":"463","author":"Mufti","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1124\/mol.106.027367","article-title":"Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells","volume":"71","author":"Peng","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B19","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.bbrc.2008.07.142","article-title":"XIAP regulates intracellular ROS by enhancing antioxidant gene expression","volume":"375","author":"Resch","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B20","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0891-5849(01)00480-4","article-title":"Redox environment of the cell as viewed through the redox state of the glutathione disulfide\/glutathione couple","volume":"30","author":"Schafer","year":"2001","journal-title":"Free Radic. Biol. Med"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1535-6108(03)00332-5","article-title":"Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity","volume":"5","author":"Schimmer","year":"2004","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B22","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/bk-2003-0845.ch026","volume-title":"Wood Deterioration and Preservation: Advances in Our Changing World","author":"Schultz","year":"2003"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B23","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1046\/j.1432-1327.2000.01595.x","article-title":"Glutathione, oxidative stress and neurodegeneration","volume":"267","author":"Schulz","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0165-1110(91)90018-Q","article-title":"Pentachlorophenol","volume":"257","author":"Seiler","year":"1991","journal-title":"Mutat. Res"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B25","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1289\/ehp.9333","article-title":"Assessing cumulative health risks from exposure to environmental mixtures - Three fundamental questions","volume":"115","author":"Sexton","year":"2007","journal-title":"Environ. Health Perspect"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B26","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.freeradbiomed.2016.12.050","article-title":"Mechanism of synergistic DNA damage induced by the hydroquinone metabolite of brominated phenolic environmental pollutants and Cu(II): Formation of DNA-Cu complex and site-specific production of hydroxyl radicals","volume":"104","author":"Shao","year":"2017","journal-title":"Free Radic. Biol. Med"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B27","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.taap.2012.11.013","article-title":"Lethal synergism between organic and inorganic wood preservatives via formation of an unusual lipophilic ternary complex","volume":"266","author":"Sheng","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/A:1009616228304","article-title":"Role of reactive oxygen species (ROS) in apoptosis induction","volume":"5","author":"Simon","year":"2000","journal-title":"Apoptosis"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B29","first-page":"794","article-title":"Production of large amounts of hydrogen peroxide by human tumor cells","volume":"51","author":"Szatrowski","year":"1991","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B30","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.mam.2005.07.015","article-title":"Copper, oxidative stress, and human health","volume":"26","author":"Uriu-Adams","year":"2005","journal-title":"Mol. Aspects Med"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B31","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/BF00194148","article-title":"Copper toxicity towards a pentachlorophenol-degrading Flavobacterium sp","volume":"52","author":"Wall","year":"1994","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1021\/tx000210p","article-title":"The lethal interaction and formation of a lipophilic ternary complex between 2,4,5-trichlorophenol and the Cu(II)-bis(1, 10-phenanthroline) complex","volume":"14","author":"Zhu","year":"2001","journal-title":"Chem. Res. Toxicol"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B33","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1039\/C5SC03796D","article-title":"Delivering the cell-impermeable DNA \u2018light-switching\u2019 Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method","volume":"7","author":"Zhu","year":"2016","journal-title":"Chem. Sci"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1006\/abbi.2000.1919","article-title":"Copper-mediated toxicity of 2, 4, 5-trichlorophenol: Biphasic effect of the copper(I)-specific chelator neocuproine","volume":"380","author":"Zhu","year":"2000","journal-title":"Arch. Biochem. Biophys"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B35","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0009-2797(00)00208-8","article-title":"Mechanism of the synergistic cytotoxicity between pentachlorophenol and copper-1,10-phenanthroline complex: The formation of a lipophilic ternary complex","volume":"129","author":"Zhu","year":"2000","journal-title":"Chem. Biol. Interact"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B36","doi-asserted-by":"crossref","first-page":"17575","DOI":"10.1073\/pnas.0704030104","article-title":"Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones","volume":"104","author":"Zhu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B37","doi-asserted-by":"crossref","first-page":"16046","DOI":"10.1073\/pnas.1204479109","article-title":"Unprecedented hydroxyl radical-dependent two-step chemiluminescence production by polyhalogenated quinoid carcinogens and H2O2","volume":"109","author":"Zhu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B38","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1021\/tx900030v","article-title":"Potential mechanism for pentachlorophenol-induced carcinogenicity: A novel mechanism for metal-independent production of hydroxyl radicals","volume":"22","author":"Zhu","year":"2009","journal-title":"Chem. Res. Toxicol"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B39","doi-asserted-by":"crossref","first-page":"11466","DOI":"10.1073\/pnas.0900065106","article-title":"Metal-independent decomposition of hydroperoxides by halogenated quinones: Detection and identification of a quinone ketoxy radical","volume":"106","author":"Zhu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B40","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jes.2017.06.035","article-title":"Intrinsic chemiluminescence production from the degradation of haloaromatic pollutants during environmentally-friendly advanced oxidation processes: Mechanism, structure-activity relationship and potential applications","volume":"62","author":"Zhu","year":"2017","journal-title":"J. Environ. Sci"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B41","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0045-6535(00)00582-8","article-title":"Synergistic cytotoxicity between pentachlorophenol and copper in a bacterial model","volume":"45","author":"Zhu","year":"2001","journal-title":"Chemosphere"},{"key":"key\n\t\t\t\t2019032711293961600_kfy307-B42","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1073\/pnas.0605527104","article-title":"Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones","volume":"104","author":"Zhu","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/168\/2\/339\/28230247\/kfy307.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T19:29:00Z","timestamp":1553714940000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/168\/2\/339\/5262237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,27]]},"references-count":42,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,12,27]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfy307","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2018,12,27]]}}}