{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:56:57Z","timestamp":1790535417212,"version":"4.1.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100011138","name":"Michigan State University AgBioResearch","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011138","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1093\/toxsci\/kfz008","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T15:11:05Z","timestamp":1546614665000},"page":"610-619","source":"Crossref","is-referenced-by-count":16,"title":["Transgenerational Effects of Periconception Heavy Metal Administration on Adipose Weight and Glucose Homeostasis in Mice at Maturity"],"prefix":"10.1093","volume":"168","author":[{"given":"Cagri","family":"Camsari","sequence":"first","affiliation":[{"name":"Laboratory of Mammalian Reproductive Biology and Genomics"},{"name":"Department of Animal Science, Michigan State University, East Lansing, Michigan 48824"},{"name":"Innovative Food Technologies Development Application and Research Center, Bolu Abant Izzet Baysal University, Bolu 14030, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K","family":"Folger","sequence":"additional","affiliation":[{"name":"Laboratory of Mammalian Reproductive Biology and Genomics"},{"name":"Department of Animal Science, Michigan State University, East Lansing, Michigan 48824"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep K","family":"Rajput","sequence":"additional","affiliation":[{"name":"Laboratory of Mammalian Reproductive Biology and Genomics"},{"name":"Department of Animal Science, Michigan State University, East Lansing, Michigan 48824"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin","family":"McGee","sequence":"additional","affiliation":[{"name":"Laboratory of Mammalian Reproductive Biology and Genomics"},{"name":"Department of Animal Science, Michigan State University, East Lansing, Michigan 48824"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith E","family":"Latham","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Michigan State University, East Lansing, Michigan 48824"},{"name":"Reproductive and Developmental Sciences Program, Department of Animal Science, Michigan State University, East Lansing, Michigan 48824"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George W","family":"Smith","sequence":"additional","affiliation":[{"name":"Laboratory of Mammalian Reproductive Biology and Genomics"},{"name":"Department of Animal Science, Michigan State University, East Lansing, Michigan 48824"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.2164\/jandrol.106.000349","article-title":"Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesis","volume":"27","author":"Anway","year":"2006","journal-title":"J. Androl"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.reprotox.2008.07.008","article-title":"Comparative anti-androgenic actions of vinclozolin and flutamide on transgenerational adult onset disease and spermatogenesis","volume":"26","author":"Anway","year":"2008","journal-title":"Reprod. Toxicol"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.brainres.2014.03.017","article-title":"Identification of sexually dimorphic genes in the neonatal mouse cortex and hippocampus","volume":"1562","author":"Armoskus","year":"2014","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.yexcr.2004.04.021","article-title":"Epigenetic activation of the 5-hydroxytryptamine (serotonin) receptor 2C in embryonal carcinoma cells is DNA replication-dependent","volume":"298","author":"Bancescu","year":"2004","journal-title":"Exp. Cell Res."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B5","doi-asserted-by":"crossref","DOI":"10.1017\/S2040174418000764","article-title":"Transgenerational effects of maternal bisphenol: A exposure on offspring metabolic health","author":"Bansal","year":"2018","journal-title":"J. Dev. Orig. Health Dis."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B6","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1093\/humrep\/dew181","article-title":"Obesity-induced oocyte mitochondrial defects are partially prevented and rescued by supplementation with co-enzyme Q10 in a mouse model","volume":"31","author":"Boots","year":"2016","journal-title":"Hum. Reprod"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1289\/EHP481","article-title":"Effects of periconception cadmium and mercury co-administration to mice on indices of chronic diseases in male offspring at maturity","volume":"125","author":"Camsari","year":"2017","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B8","doi-asserted-by":"crossref","first-page":"28.","DOI":"10.1186\/s13059-015-0591-7","article-title":"Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring","volume":"16","author":"Case","year":"2015","journal-title":"Genome Biol."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1289\/ehp.02110s111","article-title":"The three modern faces of mercury","volume":"110(Suppl. 1)","author":"Clarkson","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.envres.2014.03.019","article-title":"Prenatal exposure to environmental contaminants and body composition at age 7\u20139 years","volume":"132","author":"Delvaux","year":"2014","journal-title":"Environ. Res."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B11","doi-asserted-by":"crossref","first-page":"35983","DOI":"10.1074\/jbc.M507339200","article-title":"Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways","volume":"280","author":"D\u2019Eon","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0041-008X(84)90038-3","article-title":"Time course of cadmium-induced ultrastructural changes in rat liver","volume":"76","author":"Dudley","year":"1984","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B13","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1210\/en.2010-1461","article-title":"Maternal high-fat diet effects on third-generation female body size via the paternal lineage","volume":"152","author":"Dunn","year":"2011","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B14","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.2337\/diabetes.52.6.1340","article-title":"Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2","volume":"52","author":"El-Haschimi","year":"2003","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B15"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mad.2011.01.003","article-title":"Transgenerational endocrine pancreatic adaptation in mice from maternal protein restriction in utero","volume":"132","author":"Frantz","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B17","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1600-0773.1993.tb01348.x","article-title":"Effects of maternal dietary supplementation with selenite on the postnatal development of rat offspring exposed to methyl mercury in utero","volume":"72","author":"Fredriksson","year":"1993","journal-title":"Pharmacol. Toxicol"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbrc.2017.03.027","article-title":"Resveratrol rescues cadmium-induced mitochondrial injury by enhancing transcriptional regulation of PGC-1alpha and SOD2 via the Sirt3\/FoxO3a pathway in TCMK-1 cells","volume":"486","author":"Fu","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B19","first-page":"28","article-title":"Neurobehavioral toxicity in progeny of rat mothers exposed to methylmercury during gestation","volume":"50","author":"Gandhi","year":"2014","journal-title":"Ann. Ist. Super. Sanita"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mce.2011.10.004","article-title":"Environmentally induced epigenetic transgenerational inheritance of phenotype and disease","volume":"354","author":"Guerrero-Bosagna","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B21","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3961\/jpmph.2012.45.6.353","article-title":"Methylmercury exposure and health effects","volume":"45","author":"Hong","year":"2012","journal-title":"J. Prev. Med. Public Health"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/dmm.001180","article-title":"A comprehensive definition for metabolic syndrome","volume":"2","author":"Huang","year":"2009","journal-title":"Dis. Model. Mech"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00109-007-0240-z","article-title":"Sexually dimorphic gene expression in the heart of mice and men","volume":"86","author":"Isensee","year":"2008","journal-title":"J. Mol. Med. (Berl.)"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B24","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2009.04.020","article-title":"Current status of cadmium as an environmental health problem","volume":"238","author":"Jarup","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.toxlet.2011.05.233","article-title":"Effects of maternal cadmium exposure during late pregnant period on testicular steroidogenesis in male offspring","volume":"205","author":"Ji","year":"2011","journal-title":"Toxicol. Lett"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B26","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1186\/2251-6581-12-1","article-title":"Metabolic syndrome and menopause","volume":"12","author":"Jouyandeh","year":"2013","journal-title":"J. Diabetes Metab. Disord."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B27","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13125","article-title":"Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain","volume":"5","author":"Khalifa","year":"2017","journal-title":"Physiol. Rep."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B28","doi-asserted-by":"crossref","first-page":"494","DOI":"10.4161\/epi.24401","article-title":"Sex-specific effects of early life cadmium exposure on DNA methylation and implications for birth weight","volume":"8","author":"Kippler","year":"2013","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B29","doi-asserted-by":"crossref","first-page":"E719","DOI":"10.1152\/ajpendo.00253.2007","article-title":"Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K\/KAy mice","volume":"294","author":"Koketsu","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B30","doi-asserted-by":"crossref","first-page":"20151301.","DOI":"10.1098\/rspb.2015.1301","article-title":"Y-linked variation for autosomal immune gene regulation has the potential to shape sexually dimorphic immunity","volume":"282","author":"Kutch","year":"2015","journal-title":"Proc. Biol. Sci."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.envint.2012.08.006","article-title":"Rice consumption contributes to low level methylmercury exposure in southern China","volume":"49","author":"Li","year":"2012","journal-title":"Environ. Int."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B32","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/07435800.2015.1124437","article-title":"Sex effect on insulin secretion and mitochondrial function in pancreatic beta cells of elderly Wistar rats","volume":"41","author":"Li","year":"2016","journal-title":"Endocr. Res"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B33","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/oem.2010.059758","article-title":"Does prenatal cadmium exposure affect fetal and child growth?","volume":"68","author":"Lin","year":"2011","journal-title":"Occup. Environ. Med"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1677\/joe.0.1740167","article-title":"Estrogen receptor specificity for the effects of estrogen in ovariectomized mice","volume":"174","author":"Lindberg","year":"2002","journal-title":"J. Endocrinol."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B35","doi-asserted-by":"crossref","first-page":"e102091.","DOI":"10.1371\/journal.pone.0102091","article-title":"Pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult-onset disease through the female germline","volume":"9","author":"Manikkam","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B36","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1017\/S2040174410000231","article-title":"Altered hepatic insulin signalling in male offspring of obese mice","volume":"1","author":"Martin-Gronert","year":"2010","journal-title":"J. Dev. Orig. Health Dis"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B37","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1210\/en.2014-2020","article-title":"The effects of high-fat diet exposure in utero on the obesogenic and diabetogenic traits through epigenetic changes in adiponectin and leptin gene expression for multiple generations in female mice","volume":"156","author":"Masuyama","year":"2015","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B38","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.18632\/oncotarget.2921","article-title":"Protease nexin 1 induces apoptosis of prostate tumor cells through inhibition of X-chromosome-linked inhibitor of apoptosis protein","volume":"6","author":"McKee","year":"2015","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B39","doi-asserted-by":"crossref","first-page":"7089","DOI":"10.1128\/MCB.21.20.7089-7096.2001","article-title":"Mitogen-regulated RSK2-CBP interaction controls their kinase and acetylase activities","volume":"21","author":"Merienne","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B40","doi-asserted-by":"crossref","first-page":"180","DOI":"10.5005\/jp-journals-10005-1261","article-title":"Mercury exposure levels in children with dental amalgam fillings","volume":"7","author":"Miriam Varkey","year":"2014","journal-title":"Int. J. Clin. Pediatr. Dent."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B41","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1172\/JCI25151","article-title":"Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents","volume":"115","author":"Morino","year":"2005","journal-title":"J. Clin. Invest"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B42","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/oby.2002.59","article-title":"Fat distribution and insulin sensitivity in postmenopausal women: Influence of hormone replacement","volume":"10","author":"Munoz","year":"2002","journal-title":"Obes. Res"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B43","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1089\/ars.2006.1458","article-title":"Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications","volume":"9","author":"Nishikawa","year":"2007","journal-title":"Antioxid. Redox Signal"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B44","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2337\/diabetes.52.2.315","article-title":"Hyperactivity and reduced energy cost of physical activity in serotonin 5-HT(2C) receptor mutant mice","volume":"52","author":"Nonogaki","year":"2003","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B45","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.chemosphere.2014.07.038","article-title":"Elevated prenatal methylmercury exposure in Nigeria: Evidence from maternal and cord blood","volume":"119","author":"Obi","year":"2015","journal-title":"Chemosphere"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.reprotox.2006.08.011","article-title":"Glycine reduces cadmium-induced teratogenic damage in mice","volume":"23","author":"Paniagua-Castro","year":"2007","journal-title":"Reprod. Toxicol"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B47","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3961\/jpmph.2012.45.6.344","article-title":"Human exposure and health effects of inorganic and elemental mercury","volume":"45","author":"Park","year":"2012","journal-title":"J. Prev. Med. Public Health"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B48","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.lfs.2012.01.017","article-title":"Implications of maternal nutrient restriction in transgenerational programming of hypertension and endothelial dysfunction across F1\u2013F3 offspring","volume":"90","author":"Ponzio","year":"2012","journal-title":"Life Sci."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B49","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1210\/en.2013-1699","article-title":"Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programming in male mice","volume":"154","author":"Praktiknjo","year":"2013","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B50","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s10577-009-9063-9","article-title":"Dosage compensation and gene expression on the mammalian X chromosome: One plus one does not always equal two","volume":"17","author":"Prothero","year":"2009","journal-title":"Chromosome Res."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1530\/JOE-14-0111","article-title":"Phthalate exposure in utero causes epigenetic changes and impairs insulin signalling","volume":"223","author":"Rajesh","year":"2014","journal-title":"J. Endocrinol."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B52","doi-asserted-by":"crossref","first-page":"12369.","DOI":"10.1038\/s41598-017-12393-5","article-title":"IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits","volume":"7","author":"Rohde","year":"2017","journal-title":"Sci. Rep"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B53","first-page":"3792","article-title":"Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood","volume":"24","author":"Ronn","year":"2015","journal-title":"Hum. Mol. Genet"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B54","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1439-0531.2012.02051.x","article-title":"Effects of maternal diet and exposure to bisphenol A on sexually dimorphic responses in conceptuses and offspring","volume":"47(Suppl. 4)","author":"Rosenfeld","year":"2012","journal-title":"Reprod. Domest. Anim."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B55","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.taap.2009.04.010","article-title":"Cadmium-containing nanoparticles: Perspectives on pharmacology and toxicology of quantum dots","volume":"238","author":"Rzigalinski","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2016.05.065","article-title":"Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations","volume":"16","author":"Saben","year":"2016","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B57","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B58","doi-asserted-by":"crossref","first-page":"19351","DOI":"10.1073\/pnas.0707258104","article-title":"DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status","volume":"104","author":"Sinclair","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B59","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.envint.2013.06.014","article-title":"Prenatal exposure to environmental contaminants and behavioural problems at age 7-8years","volume":"59","author":"Sioen","year":"2013","journal-title":"Environ. Int."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B60","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.reprotox.2007.09.001","article-title":"What is an epigenetic transgenerational phenotype? F3 or F2","volume":"25","author":"Skinner","year":"2008","journal-title":"Reprod. Toxicol"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B61","doi-asserted-by":"crossref","first-page":"228.","DOI":"10.1186\/1741-7015-11-228","article-title":"Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity","volume":"11","author":"Skinner","year":"2013","journal-title":"BMC Med"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B62","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ajhg.2015.07.004","article-title":"Mutations in DDX3X are a common cause of unexplained intellectual disability with gender-specific effects on Wnt signaling","volume":"97","author":"Snijders Blok","year":"2015","journal-title":"Am. J. Hum. Genet"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B63","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxlet.2017.08.083","article-title":"Transgenerational pancreatic impairment with Igf2\/H19 epigenetic alteration induced by p,p\u2032-DDE exposure in early life","author":"Song","year":"2017","journal-title":"Toxicol. Lett"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B64","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jtemb.2012.02.004","article-title":"The toxicology of mercury and its compounds","volume":"26","author":"Syversen","year":"2012","journal-title":"J. Trace Elem. Med. Biol"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B65","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1196\/annals.1293.033","article-title":"Cadmium-induced nephropathy in rats is mediated by expression of senescence-associated beta-galactosidase and accumulation of mitochondrial DNA deletion","volume":"1011","author":"Takaki","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B66","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.reprotox.2008.02.001","article-title":"Cadmium: Toxic effects on the reproductive system and the embryo","volume":"25","author":"Thompson","year":"2008","journal-title":"Reprod. Toxicol"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B67","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10534-015-9823-2","article-title":"Mercury and metabolic syndrome: A review of experimental and clinical observations","volume":"28","author":"Tinkov","year":"2015","journal-title":"Biometals"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B68","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1021\/acs.jproteome.5b00512","article-title":"DDX3Y, a male-specific region of Y chromosome gene, may modulate neuronal differentiation","volume":"14","author":"Vakilian","year":"2015","journal-title":"J. Proteome Res."},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B69","doi-asserted-by":"crossref","first-page":"e28745.","DOI":"10.1371\/journal.pone.0028745","article-title":"Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age","volume":"6","author":"Watkins","year":"2011","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019032711393194600_kfz008-B70","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.yhbeh.2013.09.007","article-title":"Transgenerational effects of prenatal bisphenol A on social recognition","volume":"64","author":"Wolstenholme","year":"2013","journal-title":"Horm Behav."}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/168\/2\/610\/28230040\/kfz008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T19:35:57Z","timestamp":1553715357000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/168\/2\/610\/5285932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":70,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,1,10]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfz008","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.734840975.793583544","asserted-by":"object"}]},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2019,1,10]]}}}