{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:29:40Z","timestamp":1793089780922,"version":"4.5.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,3,23]],"date-time":"2019-03-23T00:00:00Z","timestamp":1553299200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"McNeil Consumer Health Care, Inc"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK102142"],"award-info":[{"award-number":["R01 DK102142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM103549 and P30 GM118247"],"award-info":[{"award-number":["P20 GM103549 and P30 GM118247"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"from the National"},{"name":"NIH Predoctoral Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"DOI":"10.1093\/toxsci\/kfz077","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T12:14:00Z","timestamp":1553084040000},"page":"57-68","source":"Crossref","is-referenced-by-count":92,"title":["Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase"],"prefix":"10.1093","volume":"170","author":[{"given":"Jephte Y","family":"Akakpo","sequence":"first","affiliation":[{"name":"Department of Pharmacology Toxicology & Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Toxicology & Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqi","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Toxicology & Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A","family":"Schaich","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W","family":"Jaeschke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Toxicology & Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret D","family":"Freudenthal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Xing","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Toxicology & Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry H","family":"Rumack","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Pediatrics, University of Colorado School of Medicine, Aurora, Colorado 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut","family":"Jaeschke","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Toxicology & Therapeutics"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,23]]},"reference":[{"key":"2019062605501820300_kfz077-B1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: A comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D. Biol. Crystallogr"},{"key":"2019062605501820300_kfz077-B2","doi-asserted-by":"crossref","DOI":"10.1177\/0960327118774902","article-title":"4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes","author":"Akakpo","year":"2018","journal-title":"Hum. Exp. Toxicol"},{"key":"2019062605501820300_kfz077-B3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jmb.2012.10.019","article-title":"Structural and functional analysis of the natural JNK1 inhibitor quercetagetin","volume":"425","author":"Baek","year":"2013","journal-title":"J. Mol. Biol"},{"key":"2019062605501820300_kfz077-B4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/toxsci\/kfl077","article-title":"Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury","volume":"94","author":"Bajt","year":"2006","journal-title":"Toxicol. Sci"},{"key":"2019062605501820300_kfz077-B5","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/toxsci\/kfr116","article-title":"Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity","volume":"122","author":"Bajt","year":"2011","journal-title":"Toxicol. Sci"},{"key":"2019062605501820300_kfz077-B6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1081\/CLT-100102445","article-title":"American academy of clinical toxicology practice guidelines on the treatment of ethylene glycol poisoning. Ad hoc committee","volume":"37","author":"Barceloux","year":"1999","journal-title":"J. Toxicol. Clin. Toxicol"},{"key":"2019062605501820300_kfz077-B7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1081\/CLT-100102881","article-title":"Treatment of methanol and isopropanol poisoning with intravenous fomepizole","volume":"39","author":"Bekka","year":"2001","journal-title":"J. Toxicol. Clin. Toxicol"},{"key":"2019062605501820300_kfz077-B8","doi-asserted-by":"crossref","first-page":"13681","DOI":"10.1073\/pnas.251194298","article-title":"SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase","volume":"98","author":"Bennett","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"2019062605501820300_kfz077-B9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1177\/0091270008327142","article-title":"Fomepizole: A critical assessment of current dosing recommendations","volume":"49","author":"Bestic","year":"2009","journal-title":"J. Clin. Pharmacol"},{"key":"2019062605501820300_kfz077-B10","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/0006-2952(88)90562-X","article-title":"Effect of piperonyl butoxide post-treatment on acetaminophen hepatotoxicity","volume":"37","author":"Brady","year":"1988","journal-title":"Biochem. Pharmacol"},{"key":"2019062605501820300_kfz077-B11","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0196-0644(94)70067-2","article-title":"4-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat","volume":"23","author":"Brennan","year":"1994","journal-title":"Ann. Emerg. Med"},{"key":"2019062605501820300_kfz077-B12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1056\/NEJM200102083440605","article-title":"Methylpyrazole for toxic alcohols study G. Fomepizole for the treatment of methanol poisoning","volume":"344","author":"Brent","year":"2001","journal-title":"N. Engl. J. Med"},{"key":"2019062605501820300_kfz077-B13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.amepre.2011.02.026","article-title":"Emergency department visits for overdoses of acetaminophen-containing products","volume":"40","author":"Budnitz","year":"2011","journal-title":"Am. J. Prev. Med"},{"key":"2019062605501820300_kfz077-B14","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/liv.13866","article-title":"Role and mechanisms of autophagy in acetaminophen-induced liver injury","volume":"38","author":"Chao","year":"2018","journal-title":"Liver Int"},{"key":"2019062605501820300_kfz077-B15","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1074\/jbc.M707630200","article-title":"CYP2E1 substrate inhibition. Mechanistic interpretation through an effector site for monocyclic compounds","volume":"283","author":"Collom","year":"2008","journal-title":"J. Biol. Chem"},{"key":"2019062605501820300_kfz077-B16","first-page":"864","article-title":"Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice","volume":"232","author":"Corcoran","year":"1985","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2019062605501820300_kfz077-B63","author":"Corcoran","year":"1986"},{"key":"2019062605501820300_kfz077-B17","first-page":"1497","article-title":"Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells","volume":"273","author":"Dai","year":"1995","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2019062605501820300_kfz077-B18","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/toxsci\/67.2.322","article-title":"Mode of cell death after acetaminophen overdose in mice: Apoptosis or oncotic necrosis?","volume":"67","author":"Gujral","year":"2002","journal-title":"Toxicol. Sci"},{"key":"2019062605501820300_kfz077-B19","doi-asserted-by":"crossref","first-page":"13565","DOI":"10.1074\/jbc.M708916200","article-title":"Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury","volume":"283","author":"Hanawa","year":"2008","journal-title":"J. Biol. Chem"},{"key":"2019062605501820300_kfz077-B20","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1006\/bbrc.2002.6541","article-title":"Reduction of toxic metabolite formation of acetaminophen","volume":"291","author":"Hazai","year":"2002","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2019062605501820300_kfz077-B21","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1038\/sj.emboj.7600212","article-title":"Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125","volume":"23","author":"Heo","year":"2004","journal-title":"Embo. J"},{"key":"2019062605501820300_kfz077-B22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/toxsci\/kfv319","article-title":"Low dose acetaminophen induces reversible mitochondrial dysfunction associated with transient c-Jun N-terminal kinase activation in mouse liver","volume":"150","author":"Hu","year":"2016","journal-title":"Toxicol. Sci"},{"key":"2019062605501820300_kfz077-B23","doi-asserted-by":"crossref","first-page":"13000","DOI":"10.1038\/s41598-017-12513-1","article-title":"CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens","volume":"7","author":"Ishii","year":"2017","journal-title":"Sci. Rep"},{"key":"2019062605501820300_kfz077-B24","first-page":"935","article-title":"Glutathione disulfide formation and oxidant stress during acetaminophen-induced hepatotoxicity in mice in vivo: The protective effect of allopurinol","volume":"255","author":"Jaeschke","year":"1990","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2019062605501820300_kfz077-B25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/03602532.2011.602688","article-title":"Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity","volume":"44","author":"Jaeschke","year":"2012","journal-title":"Drug Metab. Rev"},{"key":"2019062605501820300_kfz077-B26","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/toxsci\/kfg181","article-title":"Effect of N-acetylcysteine on acetaminophen toxicity in mice: Relationship to reactive nitrogen and cytokine formation","volume":"75","author":"James","year":"2003","journal-title":"Toxicol. Sci"},{"key":"2019062605501820300_kfz077-B27","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1177\/0192623309344087","article-title":"Mechanistic study on hepatocarcinogenesis of piperonyl butoxide in mice","volume":"37","author":"Kawai","year":"2009","journal-title":"Toxicol. Pathol"},{"key":"2019062605501820300_kfz077-B28","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1124\/jpet.102.038968","article-title":"Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione","volume":"303","author":"Knight","year":"2002","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2019062605501820300_kfz077-B29","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/toxsci\/62.2.212","article-title":"Vascular and hepatocellular peroxynitrite formation during acetaminophen toxicity: Role of mitochondrial oxidant stress","volume":"62","author":"Knight","year":"2001","journal-title":"Toxicol. Sci"},{"key":"2019062605501820300_kfz077-B30","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/hep.20437","article-title":"Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes","volume":"40","author":"Kon","year":"2004","journal-title":"Hepatology"},{"key":"2019062605501820300_kfz077-B31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1185\/030079902125000336","article-title":"Comparison of the therapeutic efficacy of 4-methylpyrazole and N-acetylcysteine on acetaminophen (paracetamol) hepatotoxicity in rats","volume":"18","author":"Kucukardali","year":"2002","journal-title":"Curr. Med. Res. Opin"},{"key":"2019062605501820300_kfz077-B32","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1016\/j.bmcl.2010.06.157","article-title":"X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors","volume":"20","author":"Kuglstatter","year":"2010","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"2019062605501820300_kfz077-B33","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.cld.2007.06.006","article-title":"Acetaminophen hepatotoxicity","volume":"11","author":"Larson","year":"2007","journal-title":"Clin. Liver Dis"},{"key":"2019062605501820300_kfz077-B34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.taap.2015.11.016","article-title":"Experimental models of hepatotoxicity related to acute liver failure","volume":"290","author":"Maes","year":"2016","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"2019062605501820300_kfz077-B35","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/pds.2090","article-title":"Characterization of acetaminophen overdose-related emergency department visits and hospitalizations in the United States","volume":"20","author":"Manthripragada","year":"2011","journal-title":"Pharmacoepidemiol. Drug Saf"},{"key":"2019062605501820300_kfz077-B36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12953-017-0122-4","article-title":"Thermal proteome profiling: Unbiased assessment of protein state through heat-induced stability changes","volume":"15","author":"Mateus","year":"2016","journal-title":"Proteome Sci"},{"key":"2019062605501820300_kfz077-B37","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3109\/15376516.2015.1094844","article-title":"A direct comparison of methods used to measure oxidized glutathione in biological samples: 2-Vinylpyridine and N-ethylmaleimide","volume":"25","author":"McGill","year":"2015","journal-title":"Toxicol. Mech. Methods"},{"key":"2019062605501820300_kfz077-B38","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.taap.2013.03.026","article-title":"Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose-response, mechanisms, and clinical implications","volume":"269","author":"McGill","year":"2013","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"2019062605501820300_kfz077-B39","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1172\/JCI59755","article-title":"The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation","volume":"122","author":"McGill","year":"2012","journal-title":"J. Clin. Invest"},{"key":"2019062605501820300_kfz077-B40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.taap.2012.08.015","article-title":"Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity","volume":"264","author":"McGill","year":"2012","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"2019062605501820300_kfz077-B41","first-page":"211","article-title":"Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione","volume":"187","author":"Mitchell","year":"1973","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2019062605501820300_kfz077-B42","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem"},{"key":"2019062605501820300_kfz077-B43","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1053\/j.gastro.2008.07.006","article-title":"Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation","volume":"135","author":"Nakagawa","year":"2008","journal-title":"Gastroenterology"},{"key":"2019062605501820300_kfz077-B44","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1055\/s-2008-1040482","article-title":"Molecular mechanisms of the hepatotoxicity caused by acetaminophen","volume":"10","author":"Nelson","year":"1990","journal-title":"Semin. Liver Dis"},{"key":"2019062605501820300_kfz077-B45","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/hep.24690","article-title":"Activation of autophagy protects against acetaminophen-induced hepatotoxicity","volume":"55","author":"Ni","year":"2012","journal-title":"Hepatology"},{"key":"2019062605501820300_kfz077-B46","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jhep.2016.04.025","article-title":"Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice","volume":"65","author":"Ni","year":"2016","journal-title":"J. Hepatol"},{"key":"2019062605501820300_kfz077-B47","doi-asserted-by":"crossref","first-page":"33698","DOI":"10.1074\/jbc.M805999200","article-title":"Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates","volume":"283","author":"Porubsky","year":"2008","journal-title":"J. Biol. Chem"},{"key":"2019062605501820300_kfz077-B48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3727\/105221617X15084371374138","article-title":"Acetaminophen toxicity: Novel Insights Into Mechanisms and Future Perspectives","volume":"18","author":"Ramachandran","year":"2018","journal-title":"Gene Expr"},{"key":"2019062605501820300_kfz077-B49","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3109\/10715762.2010.520319","article-title":"Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury","volume":"45","author":"Ramachandran","year":"2011","journal-title":"Free Radic. Res"},{"key":"2019062605501820300_kfz077-B50","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/nmeth.3652","article-title":"Thermal proteome profiling monitors ligand interactions with cellular membrane proteins","volume":"12","author":"Reinhard","year":"2015","journal-title":"Nat. Methods"},{"key":"2019062605501820300_kfz077-B51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/15563650.2012.659252","article-title":"Acetaminophen and acetylcysteine dose and duration: Past, present and future","volume":"50","author":"Rumack","year":"2012","journal-title":"Clin. Toxicol. (Phila)"},{"key":"2019062605501820300_kfz077-B52","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.taap.2010.04.015","article-title":"c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity","volume":"246","author":"Saito","year":"2010","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"2019062605501820300_kfz077-B53","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/hep.23267","article-title":"Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine","volume":"51","author":"Saito","year":"2010","journal-title":"Hepatology"},{"key":"2019062605501820300_kfz077-B54","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJM198812153192401","article-title":"Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose. Analysis of the national multicenter study (1976 to 1985)","volume":"319","author":"Smilkstein","year":"1988","journal-title":"N. Engl. J. Med"},{"key":"2019062605501820300_kfz077-B55","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"2019062605501820300_kfz077-B56","doi-asserted-by":"crossref","first-page":"15258","DOI":"10.1074\/jbc.M512953200","article-title":"Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway","volume":"281","author":"Wang","year":"2006","journal-title":"J. Biol. Chem"},{"key":"2019062605501820300_kfz077-B57","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.taap.2014.05.010","article-title":"Mechanisms of acetaminophen-induced cell death in primary human hepatocytes","volume":"279","author":"Xie","year":"2014","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"2019062605501820300_kfz077-B58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2015.03.019","article-title":"Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury","volume":"286","author":"Xie","year":"2015","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"2019062605501820300_kfz077-B59","first-page":"57","article-title":"Incidence and management of N-acetylcysteine-related anaphylactoid reactions during the management of acute paracetamol overdose","volume":"21","author":"Yamamoto","year":"2014","journal-title":"Eur. J. Emerg. Med"},{"key":"2019062605501820300_kfz077-B60","doi-asserted-by":"crossref","first-page":"459.","DOI":"10.3109\/15563650.2016.1144889","article-title":"Potential adjunct treatment for high-risk acetaminophen overdose","volume":"54","author":"Yip","year":"2016","journal-title":"Clin. Toxicol. (Phila)"},{"key":"2019062605501820300_kfz077-B61","first-page":"131","article-title":"Acetaminophen-induced hepatotoxicity: A comprehensive update","volume":"4","author":"Yoon","year":"2016","journal-title":"J. Clin. Transl. Hepatol"},{"key":"2019062605501820300_kfz077-B62","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/MJT.0b013e3181ff7ac0","article-title":"A gargantuan acetaminophen level in an acidemic patient treated solely with intravenous N-acetylcysteine","volume":"20","author":"Zell-Kanter","year":"2013","journal-title":"Am. J. Ther"}],"container-title":["Toxicological Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/toxsci\/advance-article-pdf\/doi\/10.1093\/toxsci\/kfz077\/28482735\/kfz077.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/toxsci\/article-pdf\/170\/1\/57\/28864840\/kfz077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T23:19:11Z","timestamp":1721085551000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxsci\/article\/170\/1\/57\/5418521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,23]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,3,23]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/toxsci\/kfz077","relation":{},"ISSN":["1096-6080","1096-0929"],"issn-type":[{"value":"1096-6080","type":"print"},{"value":"1096-0929","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,3,23]]}}}