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Acute kidney injury lacks a unified definition, has ambiguous semantic boundaries, and relies on defective diagnosis. This, in part, is due to the absence of biomarkers substratifying AKI patients into pathophysiological categories based on which prognosis can be assigned and clinical treatment differentiated. For instance, AKI involving acute tubular necrosis (ATN) is expected to have a worse prognosis than prerenal, purely hemodynamic AKI. However, no biomarker has been unambiguously associated with tubular cell death or is able to provide etiological distinction. We used a cell-based system to identify TCP1-eta in the culture medium as a noninvasive marker of damaged renal tubular cells. In rat models of AKI, TCP1-eta was increased in the urine co-relating with renal cortical tubule damage. When kidneys from ATN rats were perfused in situ with Krebs-dextran solution, a portion of the urinary TCP1-eta protein content excreted into urine disappeared, and another portion remained within the urine. These results indicated that TCP1-eta was secreted by tubule cells and was not fully reabsorbed by the damaged tubules, both effects contributing to the increased urinary excretion. Urinary TCP1-eta is found in many etiologically heterogeneous AKI patients, and is statistically higher in patients partially recovered from severe AKI. In conclusion, urinary TCP1-eta poses a potential, substratifying biomarker of renal cortical damage associated with bad prognosis.<\/jats:p>","DOI":"10.1093\/toxsci\/kfz242","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T07:46:30Z","timestamp":1575618390000},"page":"3-15","source":"Crossref","is-referenced-by-count":9,"title":["Urinary TCP1-eta: A Cortical Damage Marker for the Pathophysiological Diagnosis and Prognosis of Acute Kidney Injury"],"prefix":"10.1093","volume":"174","author":[{"given":"Sandra M","family":"Sancho-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"},{"name":"Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain"},{"name":"Group of Translational Research on Renal and Cardiovascular Diseases (TRECARD), Salamanca, Spain"},{"name":"Group of Biomedical Research on Critical Care (BioCritic), Valladolid, Spain"},{"name":"Spanish Renal Research Network (REDinREN), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"S\u00e1nchez-Juanes","sequence":"first","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"},{"name":"Instituto de Estudios de Ciencias de la Salud de Castilla y Le\u00f3n (IECSCYL), Soria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Blanco-Gozalo","sequence":"first","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"},{"name":"Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain"},{"name":"Group of Translational Research on Renal and Cardiovascular Diseases (TRECARD), Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Fontecha-Barriuso","sequence":"first","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"},{"name":"Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain"},{"name":"Spanish Renal Research Network (REDinREN), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Prieto-Garc\u00eda","sequence":"first","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"},{"name":"Group of Translational Research on Renal and Cardiovascular Diseases (TRECARD), Salamanca, Spain"},{"name":"Instituto de Estudios de Ciencias de la Salud de Castilla y Le\u00f3n (IECSCYL), Soria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Fuentes-Calvo","sequence":"first","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"},{"name":"Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain"},{"name":"Group of Translational Research on Renal and Cardiovascular Diseases (TRECARD), Salamanca, Spain"},{"name":"Group of Biomedical Research on Critical Care (BioCritic), Valladolid, Spain"},{"name":"Spanish Renal Research Network (REDinREN), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M","family":"Gonz\u00e1lez-Buitrago","sequence":"first","affiliation":[{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain"},{"name":"Group of Translational Research on Renal and Cardiovascular Diseases (TRECARD), Salamanca, Spain"},{"name":"Instituto de Estudios de Ciencias de la Salud de Castilla y Le\u00f3n (IECSCYL), Soria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana 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