{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:34:05Z","timestamp":1782264845983,"version":"3.54.5"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Universiti Tunku Abdul Rahman of Malaysia","award":["IPSR\/RMC\/UTARRF\/2013-C2\/B03\/6200"],"award-info":[{"award-number":["IPSR\/RMC\/UTARRF\/2013-C2\/B03\/6200"]}]},{"name":"Universiti Tunku Abdul Rahman of Malaysia","award":["IPSR\/RMC\/UTARRF\/2016\/6200\/S59"],"award-info":[{"award-number":["IPSR\/RMC\/UTARRF\/2016\/6200\/S59"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to determine whether maternal\u2013fetal blood group isoimmunization, breastfeeding, birth trauma, age when first total serum bilirubin (TSB) was measured, age of admission, and genetic predispositions to hemolysis [due to genetic variants of glucose-6-phosphate dehydrogenase (G6PD) enzyme], and reduced hepatic uptake and\/or conjugation of serum bilirubin [due to genetic variants of solute carrier organic anion transporter protein family member 1B1 (SLCO1B1) and uridine diphosphate glucuronosyltransferase family 1 member A1 (UGT1A1)] were significant risk factors associated with severe neonatal hyperbilirubinemia (SNH, TSB\u2009\u2265\u2009342\u00b5mol\/l) in jaundiced term neonates admitted for phototherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The inclusion criteria were normal term neonates (gestation \u2265 37\u2009weeks). Parents\/care-givers were interviewed to obtain data on demography, clinical problems, feeding practice and age when first TSB was measured. Polymerase chain reaction-restriction fragment length polymorphism method was used to detect common G6PD, UGT1A1 and SLCO1B1 variants on each neonate\u2019s dry blood specimens.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 1121 jaundiced neonates recruited, 232 had SNH. Logistic regression analysis showed that age (in days) when first TSB was measured [adjusted odds ratio (aOR)\u2009=\u20091.395; 95% confidence interval (CI) 1.094\u20131.779], age (in days) of admission (aOR\u2009=\u20091.127; 95% CI 1.007\u20131.260) and genetic mutant UGT1A1 promoter A(TA)7TAA (aOR\u2009=\u20094.900; 95% CI 3.103\u20137.739), UGT1A1 c.686C&amp;gt;A (aOR\u2009=\u20096.095; 95% CI 1.549\u201323.985), SLCO1B1 c.388G&amp;gt;A (aOR\u2009=\u20091.807; 95% CI 1.242\u20132.629) and G6PD variants and\/or abnormal G6PD screening test (aOR\u2009=\u20092.077; 95% CI 1.025\u20134.209) were significantly associated with SNH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Genetic predisposition, and delayed measuring first TSB and commencing phototherapy increased risk of SNH.<\/jats:p>\n               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