{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:46:17Z","timestamp":1783003577058,"version":"3.54.5"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,6]],"date-time":"2020-12-06T00:00:00Z","timestamp":1607212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Identify missed opportunities for the prevention and early diagnosis of congenital toxoplasmosis (CT) in infants followed up in a reference center for pediatric infectious diseases (PID) in Rio de Janeiro between January 2007 and December 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Descriptive study including infants with CT, diagnosis established based on Brazil\u2019s Ministry of Health\u2019s criteria. All data regarding the infants and their mother\u2019s prenatal care were collected from the medical records of the Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira (IPPMG)\u2014a tertiary public pediatric university hospital. The study enrolled infants aged between 0 and 12\u2009months followed up in the PID department of IPPMG and with confirmed infection by Toxoplasma gondii in the period between January 2007 and December 2016. All patients with diagnosis of CT registered in the PID database of the IPPMG and admitted in the above-mentioned period were included in the study. Patients whose records were not available, or who went to just one clinic appointment were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The obstetric history of all 44 women, whose infants (45) were diagnosed with CT, was analyzed. Their median age was 22\u2009years. None had undergone preconception serological testing for toxoplasmosis. Only 20 (45%) of them started antenatal care during the first trimester of gestation, a total of 24 (55%) had more than six antenatal care visits, and 16% of those did not undergo serological testing for toxoplasmosis. None were adequately informed of preventive measures. The diagnosis of acute toxoplasmosis was made in 50% of these pregnancies but 32% of the women were not treated. Only 10 children of these mothers were adequately screened and treated at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the existence of national recommendations, several opportunities were missed to prevent CT during the antenatal period and to diagnose and treat this condition in the neonatal period.<\/jats:p><\/jats:sec>","DOI":"10.1093\/tropej\/fmaa069","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T11:24:51Z","timestamp":1596194691000},"source":"Crossref","is-referenced-by-count":7,"title":["Congenital Toxoplasmosis: Missed Opportunities for Diagnosis and Prevention"],"prefix":"10.1093","volume":"67","author":[{"given":"Raquel Aitken Soares","family":"Mueller","sequence":"first","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941-912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina Cisne","family":"Frota","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941-912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Dur\u00e3o","family":"Menna Barreto","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941-912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1124-5922","authenticated-orcid":false,"given":"Daniela Pires Ferreira","family":"Vivacqua","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941-912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Bueno","family":"Loria","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941-912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana Pucarelli","family":"Lebreiro","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941-912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Guerreiro","family":"Martins","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941-912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Vigo","family":"Potsch","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941-912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Dias","family":"Maia","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941-912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel Lara Melo","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941-912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalita Fernandes","family":"Abreu","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 21941-912"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Barroso","family":"Hofer","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Disease Department, Instituto de Puericultura e Pediatria Martag\u00e3o Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil 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