{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:27:21Z","timestamp":1769012841519,"version":"3.49.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The objective of this study was to compare the efficacy and safety of heated humidified high-flow nasal cannula (HHHFNC) and nasal continuous positive airway pressure (nCPAP) for prevention of extubation failure in preterm infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Preterm infants (gestation \u226528\u2009weeks) were randomized to HHHFNC or nCPAP after extubation. Primary outcome was extubation failure within 72\u2009h of extubation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 128 preterm infants were randomized to receive either HHHFNC (n\u2009=\u200963) or nCPAP (n\u2009=\u200965) after extubation. The primary outcome of extubation failure within 72\u2009h after extubation was not different between the two groups (HHHFNC, 22.2% vs. nCPAP, 18.5%, risk difference of 3.7% and 95% CI \u221210.3 to 17.6, p\u2009=\u20090.604). The incidence of nasal trauma was significantly lower in the HHHFNC group than in the nCPAP group 6.3% vs. 21.5%, p\u2009=\u20090.020.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In our study, HHHFNC was as effective as nCPAP for prevention of extubation failure in preterm infants. Also, HHHFNC was associated with significantly less nasal trauma compared with nCPAP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmaa082","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T12:32:25Z","timestamp":1599222745000},"source":"Crossref","is-referenced-by-count":14,"title":["Heated Humidified High-Flow Nasal Cannula vs. Nasal Continuous Positive Airway Pressure for Post-extubation Respiratory Support in Preterm Infants: A Randomized Controlled Trial"],"prefix":"10.1093","volume":"67","author":[{"given":"Rameshwor","family":"Yengkhom","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Jawaharlal Nehru Institute of Medical Sciences, Imphal, Manipur 795005, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pradeep","family":"Suryawanshi","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Bharati Vidyapeeth Deemed University Medical College, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhvya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Bharati Vidyapeeth Deemed University Medical College, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujata","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Bharati Vidyapeeth Deemed University Medical College, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"2021031111254357600_fmaa082-B1","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1056\/NEJMoa072788","article-title":"Nasal CPAP or intubation at birth for very preterm infants","volume":"358","author":"Morley","year":"2008","journal-title":"N Engl J 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