{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T15:52:39Z","timestamp":1781365959109,"version":"3.54.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100019978","name":"Shanghai Pudong New Area Health Committee","doi-asserted-by":"crossref","award":["PW2017E-1"],"award-info":[{"award-number":["PW2017E-1"]}],"id":[{"id":"10.13039\/501100019978","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Science and Technology Commission","award":["19441909000"],"award-info":[{"award-number":["19441909000"]}]},{"name":"Shanghai Children s Medical Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We sought to investigate the dynamics of Mycoplasma pneumoniae (Mp) RNA in hospitalized young children with community-acquired pneumonia (CAP) and to explore whether Mp RNA clearance differed for wheezy and non-wheezy group after the onset of azithromycin treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included hospitalized young children (1\u201372\u2009months of age) with CAP caused by Mp infection. Mp RNA was detected as soon as the patient was admitted and the dynamics of Mp-RNA were monitored after the beginning of azithromycin treatment on Days 4, 7, 14 and 28.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 40 hospitalized young children with Mycoplasma pneumoniae pneumonia (Mpp), 16 had wheezing. Time to first positive Mp-RNA confirmation after symptom onset of Mpp was similar for the wheezy group (median 7\u2009days, interquartile range 7\u201310.5) and the non-wheezy group (median 7\u2009days, interquartile range 5.8\u20138.3). The duration of positive Mp-RNA detection after the onset of azithromycin treatment was shorter among the wheezy group than in the non-wheezy group (median 4 vs. 7\u2009days; hazard ratio 2.083; 95% confidence interval: 1.023\u20134.244).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Mp-RNA clearance was significantly faster among Mpp young children with wheezing than in those without wheezing after the onset of azithromycin treatment.<\/jats:p>\n                  <jats:p>Lay summary<\/jats:p>\n                  <jats:p>We sought to investigate the dynamics of Mycoplasma pneumoniae (Mp) RNA in hospitalized young children with community-acquired pneumonia and to explore whether Mp RNA clearance differed for wheezy and non-wheezy group after the onset of azithromycin treatment. Our study suggested that Mp-RNA clearance was significantly faster among Mycoplasma pneumoniae pneumonia young children with wheezing than in those without wheezing after the onset of azithromycin treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmaa109","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T20:12:29Z","timestamp":1604088749000},"source":"Crossref","is-referenced-by-count":5,"title":["Time to <i>Mycoplasma Pneumoniae<\/i> RNA Clearance for Wheezy vs. Non-Wheezy Young Children with Community-Acquired Pneumonia"],"prefix":"10.1093","volume":"67","author":[{"given":"Jiande","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Shanghai Children\u2019s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai 200127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjuan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shanghai Children\u2019s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai 200127, China"},{"name":"Department of Neonatology, Women\u2019s Hospital School of Medicine, Zhejiang University, Shangcheng, Hangzhou, Zhejiang 310006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shanghai Children\u2019s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai 200127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhua","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shanghai Children\u2019s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Pudong, Shanghai 200127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"key":"2021031111255301900_fmaa109-B1","first-page":"5","article-title":"Mycoplasma pneumoniae among children hospitalized with community-acquired pneumonia","volume":"68","author":"Kutty","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2021031111255301900_fmaa109-B2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1056\/NEJMoa1405870","article-title":"Community-acquired pneumonia requiring hospitalization among U.S. children","volume":"372","author":"Jain","year":"2015","journal-title":"N Engl J Med"},{"key":"2021031111255301900_fmaa109-B3","doi-asserted-by":"crossref","first-page":"e18928","DOI":"10.1371\/journal.pone.0018928","article-title":"Viral and atypical bacterial detection in acute respiratory infection in children under five 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