{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:48:24Z","timestamp":1787698104367,"version":"build-2784847793"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Results from early studies in the diagnostic yield of bronchoalveolar lavage (BAL) in immunocompromised adults and children were variable. This prospective study aimed to determine the diagnostic yield of BALs in immunocompromised children over the first 18\u2009months of service at a newly established children\u2019s hospital. Relationship between BAL results and changes in antimicrobial management was also studied. Twenty-one bronchoscopic BALs were performed on 18 children; 14 BALs (66.7%) yielded at least 1 pathogen and 7 (33.3%) yielded no pathogen. Two pathogens were found in 2 samples, and 1 pathogen was identified in 12 samples. Bacteria (n\u2009=\u20097 patients), viruses (n\u2009=\u20098 patients) and fungus (Pneumocycstis jirovecii in one patient) were yielded. Of the 21 BALs, 8 (38.1%) were associated with changes in antimicrobial management (Fisher\u2019s exact test, p\u2009=\u20090.018). No significant side effects such as pneumothorax or pulmonary hemorrhages were observed in this series. In conclusion, BAL in immunocompromised children is rewarding and has potential to impact on antimicrobial management.<\/jats:p>","DOI":"10.1093\/tropej\/fmaa131","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T12:08:51Z","timestamp":1608984531000},"source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic Yield of Bronchoalveolar Lavage in Immunocompromised Children"],"prefix":"10.1093","volume":"67","author":[{"given":"Jeff Chin Pang","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, The Hong Kong Children\u2019s Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6682-5529","authenticated-orcid":false,"given":"Kam Lun Ellis","family":"Hon","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, The Hong Kong Children\u2019s Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-7194","authenticated-orcid":false,"given":"Karen Ka Yan","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, The Hong Kong Children\u2019s Hospital, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyun","family":"Qian","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K C","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The University of Calgary, The Alberta Children's Hospital, Calgary, AB, Canada"},{"name":"Department of Pediatrics, The Alberta Children\u2019s Hospital, Calgary, AB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"2021021206295874600_fmaa131-B1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1183\/09031936.00.15121700","article-title":"Bronchoalveolar lavage in children. 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