{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:10:07Z","timestamp":1753877407483,"version":"3.41.2"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"The Swiss Cancer League and The National Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Reduced fertility risk is a risk in females treated with a high cumulative cyclophosphamide (CPM) dose.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The objective of this study is to establish the age at menarche, record all pregnancies, calculate age-specific fertility rate (ASFR) in female BL survivors, treated in Cameroon, in the age groups 15\u201319 and 20\u201324\u2009years, and association with an increasing cumulative CPM dose.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data collection included personal data and telephone interviews for female survivors, aged \u226512\u2009years with regards to menarche age, their mothers\u2019 menarche age, incidence and outcome of all pregnancies. The cumulative CPM\/m2 dose was categorized as low (&amp;lt;4723\u2009mg\/m2), medium (4724\u201310\u2009635\u2009mg\/m\/2) or high (&amp;gt;10\u2009635\u2009mg\/m2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median age at first treatment for 113 patients was 8\u2009years (range 3\u201317\u2009years), with median current age 17\u2009years (range 12\u201326\u2009years); the median duration of follow-up was 9\u2009years (range 1.2\u201313.3\u2009years). The median age of patients at menarche (n\u2009=\u2009109; 4 unknown) was 14\u2009years (range 10\u201317\u2009years, SD 1.19) and that of their mothers (n\u2009=\u200968; 45 unknown) 15\u2009years (range 10\u201317\u2009years, SD 1.53). The median time to first pregnancy following menarche (the fertility time) was 3.04\u2009years (n\u2009=\u200910) with low-dose CPM, 6.09\u2009years with medium-dose CPM (n\u2009=\u200981) and 6.04\u2009years with high-dose CPM (n\u2009=\u200932) (log rank difference p\u2009=\u20090.420). The ASFR in the age group 15\u201319\u2009years was 82.19 (n\u2009=\u200973) and in the age group 20\u201324\u2009years was 863.6 (n\u2009=\u200922), with significantly lower ASFR (p\u2009&amp;gt;\u20090.001) in children treated before the age of 10\u2009years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Fertility rates of girls treated for BL with CPM were normal but reduced in patients who commenced treatment before the age of 10 years.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmab004","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T23:05:42Z","timestamp":1612393542000},"source":"Crossref","is-referenced-by-count":1,"title":["Burkitt lymphoma: Age Specific Fertility Rate in 113 long-term female survivors after treatment with cyclophosphamide"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9746-6875","authenticated-orcid":false,"given":"Peter B","family":"Hesseling PhD","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn M","family":"Afungchwi MSc","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, South Africa"},{"name":"Banso Baptist Hospital, Cameroon Baptist Convention Health Board, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Njamshi Dip. Nursing","sequence":"additional","affiliation":[{"name":"Banso Baptist Hospital, Cameroon Baptist Convention Health Board, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-0180","authenticated-orcid":false,"given":"Mariana","family":"Kruger PhD","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Hospital, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Comfort","family":"Kimbi Dip Nursing","sequence":"additional","affiliation":[{"name":"Mbingo Baptist Hospital, Cameroon Baptist Convention Health Board, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patience","family":"Nfor BSc","sequence":"additional","affiliation":[{"name":"Mutengene Baptist Hospital, Cameroon Baptist Convention Health Board, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Wharin MD","sequence":"additional","affiliation":[{"name":"Beryl Thyer Memorial Africa Trust, Kettering, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Draper MSc","sequence":"additional","affiliation":[{"name":"Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine","family":"Kouya MD","sequence":"additional","affiliation":[{"name":"Mbingo Baptist Hospital, Cameroon Baptist Convention Health Board, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"2021021707215767700_fmab004-B1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1136\/bmj.303.6809.1033","article-title":"Menarche and reproduction after treatment for African Burkitt lymphoma","volume":"303","author":"Neequaye","year":"1991","journal-title":"BMJ"},{"key":"2021021707215767700_fmab004-B2","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1200\/JCO.2008.20.1541","article-title":"Fertility of female survivors of childhood cancer: a report from the Childhood Cancer Survivor Study","volume":"27","author":"Green","year":"2009","journal-title":"JCO"},{"key":"2021021707215767700_fmab004-B3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/qjmed\/92.10.551","article-title":"The effects of methotrexate on pregnancy, fertility and lactation","volume":"92","author":"Lloyd","year":"1999","journal-title":"QJM"},{"key":"2021021707215767700_fmab004-B4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1177\/0961203312468624","article-title":"The impact of cyclophosphamide on menstruation and pregnancy in women with rheumatologic disease","volume":"22","author":"Harward","year":"2013","journal-title":"Lupus"},{"key":"2021021707215767700_fmab004-B5","first-page":"347","article-title":"Cyclophophamide-induced gonadal toxicity: a treatment dilemma in patients with lupus nephritis?","volume":"62","author":"Wetzels","year":"2004","journal-title":"J Med"},{"key":"2021021707215767700_fmab004-B6","first-page":"S156","article-title":"Burkitt lymphoma: long-term outcome in 738 patients treated with cyclophosphamide-based protocols in rural Cameroon from 2003 to 2013","volume":"62","author":"Hesseling","year":"2015","journal-title":"Ped Blood Cancer"},{"key":"2021021707215767700_fmab004-B7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/08880018.2011.644881","article-title":"The Cameroon 2008 Burkitt Lymphoma Protocol. 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