{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:43:40Z","timestamp":1790127820140,"version":"4.0.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dengue and malaria co-infection has been reported in several case reports. We aim to study effect of malaria co-infection on clinical outcomes of dengue infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Records of 623 children with dengue infection, based on NS-1 antigen and IgM ELISA testing, were collected. Malaria co-infection was identified in 20 cases, based on peripheral blood smear examination. Clinical and hematological parameters were compared in two groups (malaria co-infection vs. dengue mono-infection).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Duration of hospitalization was significantly higher in co-infected group. Significantly higher proportion of malaria co-infection cases had hepatosplenomegaly, hemoglobin \u22648\u2009g\/dl, serum albumin \u22643\u2009g\/dl, serum bilirubin \u22651\u2009mg\/dl, serum aspartate aminotransferase \u2265500\u2009U\/l and serum alanine aminotransferase \u2265300\u2009U\/l. Number of transfusions (PRBC and platelets) required in malaria co-infection group was higher.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Malaria co-infection in dengue impacts clinical presentation, hematological parameters, requirement of blood transfusion and morbidity. High index of suspicion is warranted while evaluating febrile patients.<\/jats:p><\/jats:sec>","DOI":"10.1093\/tropej\/fmab006","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T20:57:12Z","timestamp":1611867432000},"source":"Crossref","is-referenced-by-count":2,"title":["Does Malaria Co-Infection Alter the Clinical Course in Children Infected with Dengue? Analysis from 623 Indian Children Admitted with Dengue Infection"],"prefix":"10.1093","volume":"67","author":[{"given":"Bhanu Kiran","family":"Bhakhri","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Superspecialty Pediatric Hospital & Postgraduate Teaching Institute, Noida, Uttar Pradesh 201301, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharmendra Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Superspecialty Pediatric Hospital & Postgraduate Teaching Institute, Noida, Uttar Pradesh 201301, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nupur","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Superspecialty Pediatric Hospital & Postgraduate Teaching Institute, Noida, Uttar Pradesh 201301, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Neonatology & MRH, Superspecialty Pediatric Hospital & Postgraduate Teaching Institute, Noida, Uttar Pradesh 201301, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"2021070811473134200_fmab006-B1","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/S0140-6736(12)61151-9","article-title":"Drivers, dynamics, and control of emerging vector-borne zoonotic diseases","volume":"380","author":"Kilpatrick","year":"2012","journal-title":"Lancet"},{"key":"2021070811473134200_fmab006-B2","doi-asserted-by":"crossref","first-page":"e0004646.","DOI":"10.1371\/journal.pntd.0004646","article-title":"Symptoms and immune markers in Plasmodium\/dengue virus co-infection compared with mono-infection with either in Peru","volume":"10","author":"Halsey","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"2021070811473134200_fmab006-B3","first-page":"25","article-title":"Clinical features, diagnostic techniques and management of dual dengue and malaria infection","volume":"19","author":"Abbasi","year":"2009","journal-title":"J Coll Physicians Surg Pak"},{"key":"2021070811473134200_fmab006-B4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ijid.2013.09.007","article-title":"Concurrent dengue and malaria infection in Lahore, Pakistan during the 2012 dengue outbreak","volume":"18","author":"Assir","year":"2014","journal-title":"Int J Infect Dis"},{"key":"2021070811473134200_fmab006-B5","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3201\/eid1504.080891","article-title":"Concurrent dengue and malaria in Cayenne hospital, French Guiana","volume":"15","author":"Carme","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"2021070811473134200_fmab006-B6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.7883\/yoken.JJID.2006.211","article-title":"Dual infection by dengue virus and Plasmodium vivax in Alappuzha District, Kerala, India","volume":"59","author":"Thangaratham","year":"2006","journal-title":"Jpn J Inf Dis"},{"key":"2021070811473134200_fmab006-B7","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/0972-9062.213508","article-title":"Manifestation and outcome concurrent malaria and dengue infection","volume":"49","author":"Mohapatra","year":"2012","journal-title":"J Vector Borne Dis"},{"key":"2021070811473134200_fmab006-B8","doi-asserted-by":"crossref","first-page":"165.","DOI":"10.1016\/j.ijid.2016.02.393","article-title":"Concurrent dengue and malaria coinfection: observations from a Central Mumbai hospital","volume":"45","author":"Barua","year":"2016","journal-title":"Int J Infect Dis"},{"key":"2021070811473134200_fmab006-B9","doi-asserted-by":"crossref","first-page":"ofx110","DOI":"10.1093\/ofid\/ofx110","article-title":"Malaria and chikungunya detected using molecular diagnostics among febrile Kenyan children","volume":"4","author":"Waggoner","year":"2017","journal-title":"Open Forum Infectious Diseases"},{"key":"2021070811473134200_fmab006-B10","doi-asserted-by":"crossref","first-page":"402","DOI":"10.4103\/ijmm.IJMM_15_455","article-title":"Evaluation of concurrent malaria and dengue infections among febrile patients","volume":"35","author":"Shah","year":"2017","journal-title":"Indian J Med Microbiol"},{"key":"2021070811473134200_fmab006-B11","doi-asserted-by":"crossref","first-page":"e3239.","DOI":"10.1371\/journal.pntd.0003239","article-title":"P. vivax malaria and dengue fever co-infection: a cross-sectional study in the Brazilian Amazon","volume":"8","author":"Magalh\u00e3es","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"2021070811473134200_fmab006-B12","doi-asserted-by":"crossref","first-page":"142.","DOI":"10.1186\/1475-2875-11-142","article-title":"Is dengue and malaria co-infection more severe than single infections? 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