{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:19:45Z","timestamp":1753877985143,"version":"3.41.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Familial Mediterranean fever (FMF) is an autoinflammatory disease characterized by abdominal and chest pain and recurrent fever due to inflammation in the serosal membranes such as peritoneum, pleura and synovia. In FMF, recurrent inflammatory cytokine production may lead to cirrhosis. The aim of this study was to determine the prevalence of FMF in children with cryptogenic cirrhosis and it was found to be high, to add FMF among the etiological causes of cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This prospective cohort study conducted at the Hospital of \u0130n\u00f6n\u00fc University, Malatya, Turkey. In this study, 44 patients diagnosed with cryptogenic cirrhosis by biopsy, in the Pediatric Gastroenterology, Hepatology and Nutrition Clinic, were included, after the other reasons that may cause chronic liver disease were excluded. MEVF gene analysis was performed for all patients with cryptogenic cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FMF genetic mutation was detected in 9 (20%) of 44 patients. M694V mutation was detected in one patient (2.27%) and E148Q homozygous mutation was detected in one patient (2.27%). Various other heterozygous mutations were detected in seven other patients. Homozygous and heterozygous R202Q mutations were detected in one patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We suggest that FMF plays a role in the etiologic differential diagnosis of cryptogenic cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1093\/tropej\/fmab019","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T20:13:41Z","timestamp":1614975221000},"source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of Familial Mediterranean Fever in Children with Cryptogenic Cirrhosis"],"prefix":"10.1093","volume":"67","author":[{"given":"Fatma \u0130lknur","family":"Varol","sequence":"first","affiliation":[{"name":"Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Faculty of Medicine, Inonu University, Malatya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7359-4944","authenticated-orcid":false,"given":"Y\u0131lmaz","family":"Tabel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Faculty of Medicine, Inonu University, Malatya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saim","family":"Yolo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Biostatistic, Faculty of Medicine, Inonu University, Malatya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Ye\u015filada","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine, Inonu University, Malatya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,8,7]]},"reference":[{"key":"2021080705530623800_fmab019-B1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.dld.2012.01.003","article-title":"Liver involvement in children with familial Mediterranean fever","volume":"44","author":"\u00dcnal","year":"2012","journal-title":"Dig Liver Dis"},{"key":"2021080705530623800_fmab019-B2","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/BOR.0000000000000315","article-title":"Familial Mediterranean fever","volume":"28","author":"Padeh","year":"2016","journal-title":"Curr Opin Rheumatol"},{"key":"2021080705530623800_fmab019-B3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/MD.0b013e31815be056","article-title":"Familial Mediterranean fever and cryptogenic cirrhosis","volume":"86","author":"Tweezer-Zaks","year":"2007","journal-title":"Medicine (Baltimore)"},{"key":"2021080705530623800_fmab019-B4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s12098-015-1985-y","article-title":"Autoinflammatory syndromes in children","volume":"83","author":"Pepper","year":"2016","journal-title":"Indian J Pediatr"},{"key":"2021080705530623800_fmab019-B5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1097\/SHK.0b013e31818335ff","article-title":"Inflammation-induced hepatotoxicity in humans","volume":"31","author":"Ramakers","year":"2009","journal-title":"Shock"},{"key":"2021080705530623800_fmab019-B6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3233\/CBM-2005-1105","article-title":"Cytokines as potential biomarkers of liver toxicity","volume":"1","author":"Lacour","year":"2005","journal-title":"Cancer Biomark"},{"key":"2021080705530623800_fmab019-B7","doi-asserted-by":"crossref","first-page":"912137","DOI":"10.1155\/2015\/912137","article-title":"Familial Mediterranean fever in Iran: a report from FMF Registration Center","volume":"2015","author":"Salehzadeh","year":"2015","journal-title":"Int J Rheumatol"},{"key":"2021080705530623800_fmab019-B8","first-page":"108","article-title":"The liver in familial Mediterranean fever: is it involved?","volume":"35 Suppl 108","author":"Ben-Chetrit","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"2021080705530623800_fmab019-B9","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/liv.14445","article-title":"Non-amyloid liver involvement in familial Mediterranean fever: a systematic literature review","volume":"40","author":"Fraisse","year":"2020","journal-title":"Liver Int"},{"key":"2021080705530623800_fmab019-B10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.gene.2012.09.073","article-title":"Prevalence of known mutations and a novel missense mutation (M694K) in the MEFV gene in a population from the Eastern Anatolia Region of Turkey","volume":"511","author":"Yesilada","year":"2012","journal-title":"Gene"},{"key":"2021080705530623800_fmab019-B11","doi-asserted-by":"crossref","first-page":"P205","DOI":"10.1186\/1546-0096-6-S1-P205","article-title":"The association of familial Mediterranean fever and cryptogenic cirrhosis","volume":"6","author":"Baskin","year":"2008","journal-title":"Pediatr Rheumatol"},{"key":"2021080705530623800_fmab019-B12","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/hep.27016","article-title":"Inflammatory and metabolic biomarkers and risk of liver and biliary tract cancer","volume":"60","author":"Aleksandrova","year":"2014","journal-title":"Hepatology"},{"key":"2021080705530623800_fmab019-B13","first-page":"150","article-title":"Current aspects of colchicine therapy-classical indications and new therapeutic uses","volume":"6","author":"Lange","year":"2001","journal-title":"Eur J Med Res"},{"key":"2021080705530623800_fmab019-B14","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.3748\/wjg.v16.i23.2889","article-title":"Colchicine reduces procollagen III and increases pseudocholinesterase in chronic liver disease","volume":"16","author":"Muntoni","year":"2010","journal-title":"World J Gastroenterol"}],"container-title":["Journal of Tropical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/tropej\/article-pdf\/67\/3\/fmab019\/39605207\/fmab019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/tropej\/article-pdf\/67\/3\/fmab019\/39605207\/fmab019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T07:58:47Z","timestamp":1671523127000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/tropej\/article\/doi\/10.1093\/tropej\/fmab019\/6344867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7,2]]}},"URL":"https:\/\/doi.org\/10.1093\/tropej\/fmab019","relation":{},"ISSN":["0142-6338","1465-3664"],"issn-type":[{"type":"print","value":"0142-6338"},{"type":"electronic","value":"1465-3664"}],"subject":[],"published-other":{"date-parts":[[2021,6,1]]},"published":{"date-parts":[[2021,6,1]]},"article-number":"fmab019"}}