{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:54:48Z","timestamp":1770026088417,"version":"3.49.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, while serious complications may occur in conjunction with both acute infection and neurological symptoms, which have been predominantly reported in adults. The neurological complications in these patients vary based on patient age and underlying comorbidities. Data on clinical features, particularly neurological features, and prognostic factors in children and adolescents are limited. This study provides a concise overview of neurological complications in pediatric COVID-19 cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>The retrospective study reviewed medical records of all patients who were admitted to our hospital and were diagnosed with COVID-19 by real-time reverse-transcription polymerase-chain-reaction (RT\u2013PCR) assay between 11 March 2020 and 30 January 2021. Patients with a positive PCR result were categorized into two groups: outpatient departments patients and inpatient departments (IPD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 2530 children who underwent RT\u2013PCR during the study period, 382 (8.6%) were confirmed as COVID-19 positive, comprising 188 (49.2%) girls and 194 (50.8%) boys with a mean age of 7.14\u00b15.84 (range, 0\u201317) years. Neurological complications that required hospitalization were present in 34 (8.9%) patients, including seizure (52.9%), headache (38.2%), dizziness (11.1%) and meningoencephalitis (5.8%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The results indicated that neurological manifestations are not rare in children suffering from COVID-19. Seizures, headaches, dizziness, anosmia, ageusia and meningoencephalitis are major neurological manifestations during acute COVID-19 disease. Although seizures were the most common cause of hospitalization in IPD patients, the frequency of meningoencephalitis was quite high. Seizures were observed as febrile seizures for children under 6 years of age and afebrile seizures for those over 6\u2009years of age. Febrile seizure accounted for half of all seizure children.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmab062","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T19:11:56Z","timestamp":1625598716000},"source":"Crossref","is-referenced-by-count":24,"title":["Neurological Manifestations of Pediatric Acute COVID Infections: A Single Center Experience"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7633-0060","authenticated-orcid":false,"given":"Beril","family":"Dilber","sequence":"first","affiliation":[{"name":"Department of Neurology, Division of Child Neurology, Health Sciences University Kanuni Training and Research Hospital, Trabzon 61000, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep G\u00f6k\u00e7e Gayretli","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Division of Child, Faculty of Medicine, 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T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye\u015feren Nil","family":"Demirhan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences University Kanuni Training and Research Hospital, Trabzon 61000, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur\u015fen","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences University Kanuni Training and Research Hospital, Trabzon 61000, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences University Kanuni Training and Research Hospital, Trabzon 61000, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ne\u015fe Yal\u00e7\u0131n","family":"Ertem","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences University Kanuni Training and Research Hospital, Trabzon 61000, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramazan","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences University Kanuni Training and Research Hospital, Trabzon 61000, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil \u0130brahim","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences University Kanuni Training and Research Hospital, Trabzon 61000, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine Esra","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Health Sciences University Kanuni Training and Research Hospital, Trabzon 61000, 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