{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:54:36Z","timestamp":1789340076733,"version":"build-2803163510"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Coronavirus disease 2019 may have neurological manifestations including meningitis, encephalitis, post-infectious brainstem encephalitis and Guillain-Barre syndrome. Neuroinflammation has been claimed as a possible cause. Here, we present a child with multisystem inflammatory syndrome in children (MIS-C) who developed pseudotumor cerebri syndrome (PTCS) during the disease course.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Case<\/jats:title>\n                  <jats:p>A 11-year-old girl presented with 5 days of fever, headache and developed disturbance of consciousness, respiratory distress, conjunctivitis and diffuse rash on her trunk. Immunoglobulin M and G antibodies against severe acute respiratory syndrome coronavirus 2 were positive in her serum. She was diagnosed with MIS-C. On day 10, she developed headache and diplopia. Left abducens paralysis and bilateral grade 3 papilledema were observed. Brain magnetic resonance imaging revealed optic nerve head protrusion, globe flattening. She was diagnosed with secondary PTCS. Papilledema and abducens paralysis improved under acetazolamide and topiramate. Neurological examination became normal after 2 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>PTCS may emerge related to MIS-C.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmab075","type":"journal-article","created":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T04:26:58Z","timestamp":1629520018000},"source":"Crossref","is-referenced-by-count":10,"title":["Pseudotumor Cerebri Syndrome as a Neurologic Involvement of Multisystem Inflammatory Syndrome in Children: A Case Report"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3757-912X","authenticated-orcid":false,"suffix":"MD","given":"Ay\u015fe \u0130rem","family":"Sofuo\u011flu","sequence":"first","affiliation":[{"name":"Division of Pediatric Intensive Care, Department of Pediatrics, Bak\u0131rkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-2226","authenticated-orcid":false,"suffix":"MD","given":"Nihal","family":"Ak\u00e7ay","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care, Department of Pediatrics, Bak\u0131rkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"\u015eevketo\u011flu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care, Department of Pediatrics, Bak\u0131rkoy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonca","family":"Bekta\u015f","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, Bak\u0131koy Dr. Sadi Konuk Research and Training Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,29]]},"reference":[{"key":"2021091111181877000_fmab075-B1","author":"World Health Organization (WHO). Coronavirus Disease (COVID-19) Dashboard","year":"2021"},{"key":"2021091111181877000_fmab075-B2","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1016\/S1473-3099(20)30651-4","article-title":"COVID-19 and multisystem inflammatory syndrome in children and adolescents","volume":"20","author":"Jiang","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"2021091111181877000_fmab075-B3","author":"Centers for Disease Control and Prevention. Reporting Multisystem Inflammatory Syndrome in Children (MIS-C)","year":"2020"},{"key":"2021091111181877000_fmab075-B4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/PCC.0000000000002599","article-title":"Caring for critically ill children with suspected or proven coronavirus disease 2019 infection: recommendations by the Scientific Sections' Collaborative of the European Society of Pediatric and Neonatal Intensive Care","volume":"22","author":"Rimensberger","year":"2021","journal-title":"Pediatr Crit Care Med"},{"key":"2021091111181877000_fmab075-B5","doi-asserted-by":"crossref","first-page":"117096","DOI":"10.1016\/j.jns.2020.117096","article-title":"Neurological involvement associated with COVID-19 infection in children","volume":"418","author":"Chen","year":"2020","journal-title":"J Neurol Sci"},{"key":"2021091111181877000_fmab075-B6","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.0b013e3182a55f17","article-title":"Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children","volume":"81","author":"Wall","year":"2013","journal-title":"Neurology"},{"key":"2021091111181877000_fmab075-B7","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1093\/brain\/awaa240","article-title":"The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings","volume":"143","author":"Paterson","year":"2020","journal-title":"Brain"},{"key":"2021091111181877000_fmab075-B8","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0140-6736(20)31725-6","article-title":"Pseudotumor cerebri syndrome associated with MIS-C: a case report","volume":"396","author":"Verkuil","year":"2020","journal-title":"Lancet"},{"key":"2021091111181877000_fmab075-B9","first-page":"234","article-title":"Increased levels of interleukins 2 and 17 in the cerebrospinal fluid of patients with idiopathic intracranial hypertension","volume":"2","author":"Edwards","year":"2013","journal-title":"Am J Clin Exp Immunol"},{"key":"2021091111181877000_fmab075-B10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.braindev.2020.10.002","article-title":"Reversible splenial lesion syndrome associated with SARS-CoV-2 infection in two children [published online ahead of print, 2020 Oct 13]","volume":"43","author":"Bekta\u015f","year":"2021","journal-title":"Brain Dev"},{"key":"2021091111181877000_fmab075-B11","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jamaneurol.2020.2687","article-title":"Neurologic and radiographic findings associated with COVID-19 infection in children [published correction appears in JAMA Neurol. 2020 Dec 1;77(12):1582]","volume":"77","author":"Abdel-Mannan","year":"2020","journal-title":"JAMA Neurol"},{"key":"2021091111181877000_fmab075-B12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pediatrneurol.2021.01.007","article-title":"Coronavirus infections in the nervous system of children: scoping review making the case for long-term neurodevelopmental surveillance","volume":"117","author":"Singer","year":"2021","journal-title":"Pediatr Neurol"},{"key":"2021091111181877000_fmab075-B13","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1177\/0333102420965963","article-title":"Isolated intracranial hypertension associated with COVID-19","volume":"40","author":"Silva","year":"2020","journal-title":"Cephalalgia"}],"container-title":["Journal of Tropical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/tropej\/article-pdf\/67\/4\/fmab075\/40346202\/fmab075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/tropej\/article-pdf\/67\/4\/fmab075\/40346202\/fmab075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T11:18:35Z","timestamp":1631359115000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/tropej\/article\/doi\/10.1093\/tropej\/fmab075\/6368331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,1]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8,27]]}},"URL":"https:\/\/doi.org\/10.1093\/tropej\/fmab075","relation":{},"ISSN":["0142-6338","1465-3664"],"issn-type":[{"value":"0142-6338","type":"print"},{"value":"1465-3664","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,8,1]]},"published":{"date-parts":[[2021,8,1]]},"article-number":"fmab075"}}