{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:04:05Z","timestamp":1791201845833,"version":"4.2.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background\/Aim<\/jats:title>\n                  <jats:p>Acute bronchiolitis is mostly caused by viral agents in children under 2 years of age. The disease mostly has a mild clinical course however severe cases are not uncommon. Vitamin D is known to exert immune-regulatory functions. We aimed to examine the association between the clinical severity of acute bronchiolitis and serum vitamin D levels in infants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>A total of 182 children with acute bronchiolitis were prospectively enrolled. The disease severity was assessed using the Modified Tal Scoring System and their vitamin D levels were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Vitamin D deficiency or insufficiency was as high as 47.8% in infants with bronchiolitis. Infants with low vitamin D levels comprised a significantly larger proportion of patients with severe bronchiolitis (p = 0.002). Infants admitted to intensive care unit had significantly higher degrees of vitamin D deficiency or insufficiency (p &amp;lt; 0.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Vitamin D deficiency is closely linked with severe bronchiolitis and the need for intensive care unit admission in infants. We believe that assessment of vitamin D levels in infants prior to bronchiolitis season and appropriate supplementation may have a protective effect against severe bronchiolitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmab081","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:32:52Z","timestamp":1631100772000},"source":"Crossref","is-referenced-by-count":13,"title":["The Relationship between Bronchiolitis Severity and Vitamin D Status"],"prefix":"10.1093","volume":"67","author":[{"given":"Yusuf","family":"Alaka\u015f","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Medical Sciences, Adana City Training and Research Hospital, Adana 01230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Celilo\u011flu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pediatrics, Pediatric Endocrinology Department, \u00c7ukurova University, Adana 01250, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orkun","family":"Tolunay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Medical Sciences, Adana City Training and Research Hospital, Adana 01230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sel\u00e7uk","family":"Matyar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Medical Sciences, Adana City Training and Research Hospital, Adana 01230, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"2021092804413981500_fmab081-B1","first-page":"2044","volume-title":"Nelson Textbook of Pediatrics","author":"Coates","year":"2016","edition":"20th 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