{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:07:31Z","timestamp":1790719651204,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Currently, there is no consensus regarding analgesic premedication before the surfactant administration by less invasive surfactant application (LISA) procedure. In this randomized controlled trial, we compared the level of comfort of preterm infants receiving fentanyl as analgesic and sedative versus no fentanyl during LISA procedure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We randomized 34 preterm infants of 28+0\u201333+6\u2009weeks of gestation with respiratory distress syndrome (RDS) within 6\u2009h of birth to receive either fentanyl (1\u2009\u03bcg\/kg intravenous) or no premedication during surfactant administration by LISA procedure. Primary objective was to assess the proportion of preterm infants to be comfortable during the procedure [revised premature infant pain profile (R-PIPP) score \u226412] and secondarily complications occurring during the procedure, hemodynamically significant patent ductus arteriosus (hsPDA), intraventricular hemorrhage (IVH) (\u2265 grade 3), bronchopulmonary dysplasia (BPD) and composite outcome of BPD\/mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Proportion of preterm infants with a R-PIPP score \u226412 during LISA was significantly higher in the fentanyl group [15\/17 (88.23%) vs. 8\/17 (47.05%); p value 0.025]. There were no differences in secondary outcome parameters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Low-dose fentanyl during LISA procedure resulted in more comfort in preterm infants and without increased complication of both the LISA procedure and fentanyl administration. Further studies are needed to determine the safest and most effective pharmacologic measures to prevent pain and discomfort during LISA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmac019","type":"journal-article","created":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T12:07:55Z","timestamp":1644667675000},"source":"Crossref","is-referenced-by-count":19,"title":["Premedication with Fentanyl for Less Invasive Surfactant Application (LISA): A Randomized Controlled Trial"],"prefix":"10.1093","volume":"68","author":[{"given":"Habibullah","family":"Sk","sequence":"first","affiliation":[{"name":"Department of Neonatology, Institute of Post Graduate Medical, Education & Research and SSKM Hospital, Kolkata 700020, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-9225","authenticated-orcid":false,"given":"Bijan","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Institute 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