{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T23:12:38Z","timestamp":1756681958133,"version":"3.41.2"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Coordination of Superior Level Staff Improvement"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To describe the 25-hydroxyvitamin D [25(OH)D] concentrations in children and adolescents and to verify the association with the body mass index z-score (ZBMI), lipid profile and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Cross-sectional study with 170 children and adolescents aged between 4 and 15\u2009years (106 normal weight and 64 overweight) from a public institution in Santo Andr\u00e9\u2014Brazil. Weight, height and waist circumference were verified and ZBMI and waist-to-height ratio (WHtR) were calculated. Biochemical analysis: 25(OH)D levels [deficiency: 25(OH)D\u2009&amp;lt;\u200920\u2009ng\/ml]; glycemia and insulin (HOMA-IR), lipid profile and ultra-sensitive C-reactive protein.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean age was 8.37\u2009\u00b1\u20093.17\u2009years; 89 (52.4%) were male; 77 (45.3%) Caucasians and 121 (71.2%) pre-pubescent. Overweight was observed in 64 (37.6%), dyslipidemia in 108 (63.5%) and 25(OH)D deficiency in 117 (68.8%) of the individuals. ZBMI (r = \u22120.209; p\u2009=\u20090.006), WHtR (r = \u22120.154; p\u2009=\u20090.045), triglycerides (TGs) (r = \u22120.161; p\u2009=\u20090.037) and TGs\/high-density lipoprotein (HDL) ratio (r = \u22120.168; p\u2009=\u20090.028) were inversely correlated with 25(OH)D concentrations. Overweight children and adolescents were four times more likely to have vitamin D deficiency (odds ratio\u2009=\u20094.28; 95% confidence interval 1.152 to 4.907; p\u2009=\u20090.019), after adjustment for pubertal development (prepubertal), sex (male), HDL-c (&amp;lt;45\u2009mg\/dl), non-HDL (&amp;gt;120\u2009mg\/dl), TG\/HDL ratio (&amp;gt;2.0) and HOMA-IR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A high prevalence of vitamin D deficiency (68.8%) was observed. There was an independent association between vitamin D deficiency and overweight, not observed for dyslipidemia and insulin resistance. The data point to the need for periodic monitoring of serum concentrations of 25(OH)D and reinforcement of guidelines for combating and preventing overweight in the pediatric age group.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmac033","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T11:14:31Z","timestamp":1649934871000},"source":"Crossref","is-referenced-by-count":4,"title":["Is There an Association between Vitamin D Concentrations and Overweight in Children and Adolescents?"],"prefix":"10.1093","volume":"68","author":[{"given":"Stephanie Ramos","family":"Coelho","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04021-001, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0674-5607","authenticated-orcid":false,"given":"Jo\u00e3o Carlos Pina","family":"Faria","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Centro Universit\u00e1rio\u2014FMABC, Santo Andr\u00e9 09060-870, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando Luiz Affonso","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04021-001, Brazil"},{"name":"Department of Pediatrics, Centro Universit\u00e1rio\u2014FMABC, Santo Andr\u00e9 09060-870, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola Isabel Suano","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04021-001, Brazil"},{"name":"Department of Pediatrics, Centro Universit\u00e1rio\u2014FMABC, Santo Andr\u00e9 09060-870, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roseli Oselka 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