{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:59:55Z","timestamp":1789016395829,"version":"build-2803163510"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Brazil has one of the highest numbers of births with sickle-cell disease (SCD) in the Americas. Despite the risk of severe illnesses and death due to both vaccine-preventable infections, vaccination uptake in pediatric patients with SCD is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Material and methods<\/jats:title>\n                  <jats:p>Children under 18\u2009years with SCD presenting to routine medical consultations had their vaccination status evaluated according to the national recommendations. Data obtained were classified as \u2018Adequate\u2019, \u2018Delayed\u2019 or \u2018Missing\u2019 vaccination and compared among age groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From 117 children screened, 100 had their vaccination card available. Vaccination coverage of routine vaccines was above 95% for all primary series and both age groups, with varied rates of delays and low missing doses. Among SCD extended vaccination, the most frequently delayed and missed vaccines were those specifically recommended to individuals with SCD as per national guidelines\u2014and particularly those against encapsulated bacteria. Significant and varied rates of missing doses occurred in primary series and booster doses for PPSV23, Hib, menC, hepatitis A and varicella. The average influenza vaccination rate was 69.5%, with higher rates among younger children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Children with SCD have alarming under-vaccination rates. Basic prevention strategies in Brazil should be reassessed in this specific population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmac034","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T11:10:52Z","timestamp":1650021052000},"source":"Crossref","is-referenced-by-count":6,"title":["Vaccination in Pediatric Patients with Sickle-Cell Disease: Uptake Report and Mini-Review"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4825-7396","authenticated-orcid":false,"given":"Daniel","family":"Jarovsky","sequence":"first","affiliation":[{"name":"Pediatric Infectious Diseases, Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo 01221-010, Brazil"},{"name":"Santa Casa School of Medical Sciences, S\u00e3o Paulo 01221-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillipe Romanzini","family":"Bastos","sequence":"additional","affiliation":[{"name":"Santa Casa School of Medical Sciences, S\u00e3o Paulo 01221-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Faria","family":"de Matos","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo 01221-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Jacqueline","family":"Almeida","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo 01221-010, Brazil"},{"name":"Santa Casa School of Medical Sciences, S\u00e3o Paulo 01221-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio Palazzi","family":"S\u00e1fadi","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo 01221-010, Brazil"},{"name":"Santa Casa School of Medical Sciences, S\u00e3o Paulo 01221-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella Campos Oliveira","family":"Hegg","sequence":"additional","affiliation":[{"name":"Pediatric Hematology & Oncology, Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo 01221-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Maria","family":"Luporini","sequence":"additional","affiliation":[{"name":"Pediatric Hematology & Oncology, Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo 01221-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan Naaman","family":"Berezin","sequence":"additional","affiliation":[{"name":"Pediatric Infectious Diseases, Santa Casa de S\u00e3o Paulo, S\u00e3o Paulo 01221-010, Brazil"},{"name":"Santa Casa School of Medical Sciences, S\u00e3o Paulo 01221-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"2022051008135576500_fmac034-B1","doi-asserted-by":"crossref","first-page":"18010","DOI":"10.1038\/nrdp.2018.10","article-title":"Sickle cell disease","volume":"4","author":"Kato","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"2022051008135576500_fmac034-B2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0140-6736(12)61229-X","article-title":"Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates","volume":"381","author":"Piel","year":"2013","journal-title":"Lancet"},{"key":"2022051008135576500_fmac034-B3","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1182\/blood-2010-07-299636","article-title":"Pathophysiology of sickle cell disease is mirrored by the red blood cell 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