{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:06:40Z","timestamp":1791616000642,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Delaying umbilical cord clamping facilitates postnatal transition in neonates but evidence on its effect in reducing hemodynamic instability in preterm neonates is inconclusive.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>To evaluate delayed cord clamping (DCC) in reducing the incidence of hemodynamic instability in preterm neonates below 35\u2009weeks gestational age admitted to the neonatal intensive care unit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Neonates between 25\u2009weeks and 34\u2009weeks and 6\u2009days gestation were enrolled. Hemodynamic and respiratory parameters were monitored over 48\u2009h. Hemodynamic instability was defined as persistent tachycardia and\/or hypotension necessitating therapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The DCC cohort included 62 neonates with an equal number in the non-DCC group. The birth weight [mean\u2009\u00b1\u2009standard deviation (SD)] was 1332.90\u2009\u00b1\u2009390.05 g and the gestational age (mean\u2009\u00b1\u2009SD) was 31.64\u2009\u00b1\u20092.52 weeks. Hemodynamic instability was noted in 18\/62 (29%) neonates in the DCC cohort and 29\/62 (46.7%) in the non-DCC group; relative risk (RR) 0.62 [95% confidence interval (CI) 0.38\u20130.99] (p\u2009=\u20090.023). The duration of inotrope requirement in the DCC cohort (mean\u2009\u00b1\u2009SD) was 38.38\u2009\u00b1\u200916.99\u2009h compared to 49.13\u2009\u00b1\u200922.90\u2009h in the non-DCC cohort (p\u2009=\u20090.090). Significantly higher systolic, diastolic and mean arterial pressures were noted from 6\u2009h to 48\u2009h in the DCC cohort (p\u2009&amp;lt;\u20090.001). The severity of respiratory distress and FiO2 requirement was also less in the first 24\u2009h. There was no difference in the incidence of patent ductus arteriosus, late-onset sepsis or mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Delaying umbilical cord clamping at birth by 60\u2009s resulted in significantly lower hemodynamic instability in the first 48\u2009h and higher blood pressure parameters.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmac035","type":"journal-article","created":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T11:06:36Z","timestamp":1650798396000},"source":"Crossref","is-referenced-by-count":3,"title":["Effect of Delayed Umbilical Cord Clamping on Hemodynamic Instability in Preterm Neonates below 35 Weeks"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6189-1420","authenticated-orcid":false,"given":"Vishal Vishnu","family":"Tewari","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Command Hospital (SC) , Pune 411040, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet","family":"Saurabh","sequence":"additional","affiliation":[{"name":"Armed Forces Medical College , Pune 411040, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruv","family":"Tewari","sequence":"additional","affiliation":[{"name":"Undergraduate Wing, University College of Medical Sciences , New Delhi 110095, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Gaurav","sequence":"additional","affiliation":[{"name":"Armed Forces Medical College , Pune 411040, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishwo Raj Bahadur","family":"Kunwar","sequence":"additional","affiliation":[{"name":"Armed Forces Medical College , Pune 411040, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishabh","family":"Khashoo","sequence":"additional","affiliation":[{"name":"Undergraduate Wing, University College of Medical Sciences , New Delhi 110095, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Armed Forces Medical College , Pune 411040, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Yadav","sequence":"additional","affiliation":[{"name":"Armed Forces Medical College , Pune 411040, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urmila","family":"Bharti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, NICU, Command Hospital (SC) , Pune 411040, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakti","family":"Vardhan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Armed Forces Medical College , Pune 411040, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"2022080806090612400_fmac035-B1","author":"Royal College of Obstetricians and Gynaecologists Scientific Impact Paper. 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