{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:21:02Z","timestamp":1790313662770,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100010804","name":"Faculty of Medicine, Prince of Songkla University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To study the prevalence of anemia among healthy infants, and outcomes of giving a therapeutic trial of iron to anemic infants in thalassemia-endemic area.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A cross sectional study was conducted in 6\u20139-month-old, full-term healthy infants who attended the well child clinics at 2 tertiary care centers in southern Thailand. Complete blood count and serum ferritin were performed in every infant, and hemoglobin typing was performed only in anemic cases. All anemic infants were given a therapeutic trial of iron and categorized into either; iron responder (hemoglobin increased \u2265 1 g\/dL) or iron non-responder (hemoglobin increased &amp;lt;1 g\/dL) groups after one month of the therapeutic trial. Mean levels of hematological parameters, including the Mentzer index, were compared within the groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 620 infants were included in the study. From this, 230 infants (37%) were anemic for which iron deficiency contributed for 80% of the etiology. The iron responder group showed significant improvement in hematological parameters after a trial of iron, while there was no improvement in the iron non-responder group. Among iron responders, there were 31 out of 186 infants (16.6%) who had coexisting abnormal hemoglobin typing, and their post-treatment complete blood count still showed a mean corpuscular volume &amp;lt; 70, with a Mentzer index &amp;lt; 13.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Iron deficiency remains a major cause of anemia among infants, and a therapeutic trial of iron is beneficial in this age group, even though thalassemia trait\/hemoglobinopathy can co-exist.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmac044","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T14:27:12Z","timestamp":1655389632000},"source":"Crossref","is-referenced-by-count":4,"title":["Coexisting Iron Deficiency Anemia and Thalassemia Traits in Infants: Implication for an Anemia Screening Program"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-9050","authenticated-orcid":false,"given":"Sasivara","family":"Boonrusmee","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Division of Ambulatory Pediatrics, Department of Pediatrics, Prince of Songkla University , Songkhla 90110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunwan","family":"Thongkhao","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Ambulatory Pediatrics, Department of Pediatrics, Prince of Songkla University , Songkhla 90110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malai","family":"Wongchanchailert","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Ambulatory Pediatrics, Department of Pediatrics, Prince of Songkla University , Songkhla 90110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladda","family":"Mo-Suwan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Ambulatory Pediatrics, Department of Pediatrics, Prince of Songkla University , Songkhla 90110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasuree","family":"Sangsupawanich","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Division of Ambulatory Pediatrics, Department of Pediatrics, Prince of Songkla University , Songkhla 90110, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,16]]},"reference":[{"key":"2022061614262762900_fmac044-B1","volume-title":"Anaemia in Women and Children","author":"WHO","year":"2021"},{"key":"2022061614262762900_fmac044-B2","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1017\/S1368980008002401","article-title":"Worldwide prevalence of anaemia. WHO Vitamin and Mineral Nutrition Information System, 1993-2005","volume":"12","author":"McLean","year":"2009","journal-title":"Public Health Nutr"},{"key":"2022061614262762900_fmac044-B3","volume-title":"Guidelines: Intermittent Iron Supplementation in Preschool and School-Age Children","author":"WHO","year":"2021"},{"key":"2022061614262762900_fmac044-B4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.spen.2006.08.004","article-title":"Iron deficiency and brain development","volume":"13","author":"Lozoff","year":"2006","journal-title":"Semin Pediatr Neurol"},{"key":"2022061614262762900_fmac044-B5","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1001\/archpedi.160.11.1108","article-title":"Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years","volume":"160","author":"Lozoff","year":"2006","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2022061614262762900_fmac044-B6","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.3390\/nu6104093","article-title":"Identification, prevention and treatment of iron deficiency during the first 1000 days","volume":"6","author":"Burke","year":"2014","journal-title":"Nutrients"},{"key":"2022061614262762900_fmac044-B7","volume-title":"Guideline for the Control and Prevention of Iron Deficiency Anemia","author":"Ministry of Public Health. 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Bureau of Nutrition","year":"2014"},{"key":"2022061614262762900_fmac044-B8","volume-title":"Guideline in Child Health Supervision.","author":"The Royal College of Pediatricians of Thailand and The Paediatrics Society of Thailand","year":"2014"},{"key":"2022061614262762900_fmac044-B9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41390-020-0907-5","article-title":"Prevention of iron deficiency anemia in infants and toddlers","volume":"89","author":"Sundararajan","year":"2021","journal-title":"Pediatr Res"},{"key":"2022061614262762900_fmac044-B10","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/ajcn\/82.2.380","article-title":"Only a small proportion of anemia in northeast Thai schoolchildren is associated with iron deficiency","volume":"82","author":"Thurlow","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"2022061614262762900_fmac044-B11","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000322666","article-title":"Anemia, iron deficiency and thalassemia among adolescents in Northeast Thailand: results from two independent surveys","volume":"125","author":"Pansuwan","year":"2011","journal-title":"Acta Haematol"},{"key":"2022061614262762900_fmac044-B12","doi-asserted-by":"crossref","DOI":"10.31584\/jhsmr.2018.36.3.11","article-title":"Anemia and iron deficiency anemia in high school girls in Nakhon Si Thammarat, Thailand","volume":"36","author":"Sarakul","year":"2018","journal-title":"J Health Sci Med Res"},{"key":"2022061614262762900_fmac044-B13","volume-title":"Vitamin and Mineral Nutrition Information System","author":"WHO. 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