{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:24:32Z","timestamp":1787786672995,"version":"build-2784847793"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","award":["A2020232"],"award-info":[{"award-number":["A2020232"]}],"id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Health Science and Technology Plan of Shantou"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Clinical data with respect to the impact of meconium on the prognosis of neonatal bacterial meningitis are scarce. Therefore, in this study, we aimed to determine whether meconium-stained amniotic fluid (MSAF) represents a risk factor for poor prognosis of neonatal bacterial meningitis in a confirmed case population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study of 256 neonates diagnosed with bacterial meningitis hospitalized at one of three hospitals in Shantou, China, between October 2013 and September 2018. Clinical manifestation, laboratory test results and treatment were compared between the two groups, with outcomes dichotomized into \u2018good\u2019 or \u2018poor\u2019 prognosis. Multivariate analysis and follow-up logistic regression analysis were used to identify predictive factors of a poor outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 256 neonates with BM, 95 (37.1%) had a good prognosis at discharge and 161 (62.9%) had a poor prognosis. In the poor prognosis group, 131\/161 (79.4%) neonates had a permanent neurological sequelae and 19 (11.8%) had \u22652 sequelae. Of note, 11 neonates died. The rate of poor prognosis of BM was significantly higher among neonates with than without MSAF (26.1% vs. 12.6%, respectively; p\u2009&amp;lt;\u20090.05). A logistic multivariate analysis to evaluate the prognostic effect of MSAF to BM showed that neonatal with MSAF is more likely to have a worse prognosis of BM [unadjusted odds ratio (OR), 2.44, 95% confidence interval (CI), 1.24\u20135.10; adjusted OR, 2.31; 95% CI, 1.09\u20135.17].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MSAF is significantly associated with poor prognosis of neonatal bacterial meningitis. Therefore, in case of MSAF, more attention should be paid to neonatal bacterial meningitis.<\/jats:p><\/jats:sec>","DOI":"10.1093\/tropej\/fmac064","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T15:57:03Z","timestamp":1660406223000},"source":"Crossref","is-referenced-by-count":3,"title":["Meconium-Stained Amniotic Fluid: Impact on Prognosis of Neonatal Bacterial Meningitis"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6109-9946","authenticated-orcid":false,"given":"Ya-Ting","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu-Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shantou Central Hospital , Shantou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Yu","family":"Wen","sequence":"additional","affiliation":[{"name":"Clinical Data Center, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Min","family":"Deng","sequence":"additional","affiliation":[{"name":"Clinical Data Center, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ping","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Third Affiliated Hospital of Sun Yat-Sen University , Guangzhou, 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