{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:46:33Z","timestamp":1788389193387,"version":"build-2803163510"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>HIV infection is still a serious public health issue globally. Suboptimal vitamin D status is highly prevalent in HIV-infected children and adolescents throughout the world.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the outcome of vitamin D supplementation on CD4 count in HIV-infected children and adolescents with suboptimal vitamin D status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Vitamin D level of HIV-infected children and adolescents were measured at enrolment. Suboptimal vitamin D level was defined as 25(OH)D\u2009&amp;lt;\u200930\u2009ng\/ml. Vitamin D insufficiency and deficiency were defined as 21\u201329 and &amp;lt;20\u2009ng\/ml, respectively. Children with suboptimal vitamin D levels were supplemented with vitamin D.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>This was a single-centre, non-randomized comparative study enrolling 50 eligible participants. There were 20 patients who were vitamin D sufficient, 7 were vitamin D insufficient and 23 were found to be vitamin D deficient at enrolment. However, after supplementation, the status of sufficient remained same and 7 insufficient become sufficient, whereas in 23 deficient, 18 (78.3%) become sufficient and 5 (21.7%) become insufficient and this change was found statistically significant among the groups (\u03c72 = 6.52, p\u2009=\u20090.038). There was a significant improvement of CD4 count from baseline to 4\u2009months in deficient group on vitamin D supplementation (p value\u2009&amp;lt;\u20090.001; 1.2-fold rise). No significant change was seen in vitamin D insufficient (p value = 0.791) and sufficient groups (p value = 0.168).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Vitamin D should be supplemented in HIV-infected children on ART with low CD4 counts.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmac066","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T18:30:51Z","timestamp":1660069851000},"source":"Crossref","is-referenced-by-count":3,"title":["Effect of Vitamin D Supplementation on CD4 Count in HIV-Infected Children and Adolescents in North India: A Non-Randomized Comparative Study"],"prefix":"10.1093","volume":"68","author":[{"given":"Prabha","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Pediatrics, S.N. Children Hospital, M.L.N. Medical College , Prayagraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anubha","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S.N. Children Hospital, M.L.N. Medical College , Prayagraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9600-0667","authenticated-orcid":false,"given":"Shahid Akhtar","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S.N. Children Hospital, M.L.N. Medical College , Prayagraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S.N. Children Hospital, M.L.N. Medical College , Prayagraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh Vir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S.N. Children Hospital, M.L.N. Medical College , Prayagraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambuj","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S.N. Children Hospital, M.L.N. Medical College , Prayagraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9239-4358","authenticated-orcid":false,"given":"Manisha","family":"Maurya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S.N. Children Hospital, M.L.N. Medical College , Prayagraj, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-500X","authenticated-orcid":false,"given":"Nandita","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, S.N. Children Hospital, M.L.N. 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