{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:23:39Z","timestamp":1784053419522,"version":"3.55.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,6]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background and objectives<\/jats:title>\n                  <jats:p>Early onset sepsis (EOS) in neonates is a scourge that contributes to morbidity and mortality. Prominent stakeholders recommend universal screening of antenatal women for Group B Streptococcus (GBS) and intrapartum antibiotic prophylaxis (IAP) for those who are carriers. However, there are controversies. Other guidelines allow region-specific protocols due to sociodemographic, geographical and ethnic differences. We planned to analyze the prevalence of GBS rectovaginal carriage at 36\u201337\u2009weeks gestation and its effect on early neonatal status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This prospective multidisciplinary study (Obstetrics, Perinatology, Neonatology, Microbiology and Infectious diseases) was conducted in our tertiary care center between February 2020 and May 2021.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In our study group which included 966 mothers who delivered at the hospital, 4.8% of mothers who were screened by genito-rectal swabs were positive for GBS at 36\u201337 weeks gestation. All these mothers were given IAP as per protocol. Other organisms detected on screening mothers were Candida and Gram-negative bacteria. None of the neonates born to these mothers required any intensive care unit admission or therapy for systemic illness. There was no difference in clinically relevant outcomes between neonates who were born to GBS-positive mothers as compared to those born to negative screen result mothers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>GBS prevalence in our cohort was lower than most scientific reports. The neonates born to carrier mothers did not present with signs of early-onset sepsis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmac092","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T15:35:24Z","timestamp":1666971324000},"source":"Crossref","is-referenced-by-count":3,"title":["Prevalence of Group B Streptococcus in pregnant women in Kerala and relation to neonatal outcomes: a prospective cross-sectional study"],"prefix":"10.1093","volume":"68","author":[{"given":"Girija","family":"Gurudas","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kerala Institute of Medical Sciences , Trivandrum 695029, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajalakshmi","family":"Arjun","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Kerala Institute of Medical Sciences , Trivandrum 695029, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Kerala Institute of Medical Sciences , Trivandrum 695029, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidyalekshmy","family":"Ranganayaki","sequence":"additional","affiliation":[{"name":"Department of High Risk Obstetrics and Perinatology, Kerala Institute of Medical Sciences , Trivandrum 695029, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinnu","family":"Sasikumar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kerala Institute of Medical Sciences , Trivandrum 695029, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viji","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Kerala Institute of Medical Sciences , Trivandrum 695029, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Febeena","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Kerala Institute of Medical Sciences , Trivandrum 695029, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-6003","authenticated-orcid":false,"given":"Femitha","family":"Pournami","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Kerala Institute of Medical Sciences , Trivandrum 695029, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,28]]},"reference":[{"key":"2022102814274863700_fmac092-B1","first-page":"e19e40","article-title":"Prevention of Group B Streptococcal early onset disease in newborns","volume":"134","author":"ACOG Committee Opinion","year":"2019","journal-title":"Obstet Gynecol"},{"key":"2022102814274863700_fmac092-B2","first-page":"181","article-title":"Prevalence of group B Streptococcal colonization among pregnant women and neonates in a tertiary hospital in India","volume":"18","author":"Santhanam","year":"2017","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"2022102814274863700_fmac092-B3","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1097\/AOG.0000000000003668","article-title":"Prevention of Group B Streptococcal early onset disease in newborns","volume":"135","author":"Committee on Obstetric Practice","year":"2020","journal-title":"Obstet Gynecol"},{"key":"2022102814274863700_fmac092-B4","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.1111\/1471-0528.14821","article-title":"Prevention of neonatal early onset group B streptococcal disease. 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