{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:20:24Z","timestamp":1793110824015,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although many improvements in neonatal care have been achieved, mortality rates for sepsis and septic shock in newborns are still high. The vasoactive inotropic score (VIS) was designed and studied to predict mortality in different settings. There are currently no data on the predictive ability of the VIS for mortality in newborn patients with septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with late-onset neonatal sepsis who required inotropes because of fluid-refractory septic shock during the study period were included in the study. Four distinct VIS\u00a0values were calculated for each septic shock episode after inotropic treatment had begun, that is, at the initiation of inotropic treatment and at 24 and 48\u2009h after inotropic treatment had begun, and the highest VIS (VISmax) at any time after initiation of inotropic agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 98 episodes studied were divided into two groups according to the outcomes of their sepsis episodes as survivors (n\u2009=\u200939) or nonsurvivors (n\u2009=\u200959). The areas under the curve of the VIS values for the prediction of mortality were the VISmax (0.819, p\u2009&amp;lt;\u20090.001), followed by the VIS48 (0.802, p\u2009&amp;lt;\u20090.001), VIS24 (0.762, p\u2009=\u20090.001) and VIS0 (0.699, p\u2009=\u20090.015). Patients with a VISmax of greater than 20 had significantly higher odds of mortality (p\u2009&amp;lt;\u20090.001, \u03b2\u2009=\u200914.7, 95% confidence interval [4.7\u201345.9]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found that the VISmax was an easy-to-use and helpful tool for predicting a poor outcome in neonatal sepsis. Physicians should be aware that the prognosis is poor for any newborn with a VIS of 20 or greater at any point after the onset of sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/tropej\/fmac100","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T17:40:54Z","timestamp":1668015654000},"source":"Crossref","is-referenced-by-count":17,"title":["Vasoactive inotropic score as a predictor of mortality in neonatal septic shock"],"prefix":"10.1093","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5476-0353","authenticated-orcid":false,"given":"Salih","family":"Demirhan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Health Sciences, Zeynep Kamil Maternity and Children\u2019s Training and Research Hospital , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevilay","family":"Topcuoglu","sequence":"additional","affiliation":[{"name":"Divison of Neonatology, Department of Pediatrics, University of Health Sciences, Zeynep Kamil Maternity and Children\u2019s Training and Research Hospital , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilgun","family":"Karadag","sequence":"additional","affiliation":[{"name":"Divison of Neonatology, Department of Pediatrics, University of Health Sciences, Zeynep Kamil Maternity and Children\u2019s Training and Research Hospital , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Ozalkaya","sequence":"additional","affiliation":[{"name":"Divison of Neonatology, Department of Pediatrics, University of Health Sciences, Zeynep Kamil Maternity and Children\u2019s Training and Research Hospital , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guner","family":"Karatekin","sequence":"additional","affiliation":[{"name":"Divison of Neonatology, Department of Pediatrics, University of Health Sciences, Zeynep Kamil Maternity and Children\u2019s Training and Research Hospital , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"2022111815171942300_fmac100-B1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2471\/BLT.14.139790","article-title":"Neonatal cause-of-death estimates for the early and late neonatal periods for 194 countries: 2000-2013","volume":"93","author":"Oza","year":"2015","journal-title":"Bull World Health Organ"},{"key":"2022111815171942300_fmac100-B2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fped.2020.00050","article-title":"ECMO for neonatal sepsis in 2019","volume":"8","author":"Butt","year":"2020","journal-title":"Front Pediatr"},{"key":"2022111815171942300_fmac100-B3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.clp.2010.04.002","article-title":"Pathophysiology and treatment of septic shock in neonates","volume":"37","author":"Wynn","year":"2010","journal-title":"Clin Perinatol"},{"key":"2022111815171942300_fmac100-B4","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1161\/01.CIR.92.8.2226","article-title":"Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. 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