{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:41:52Z","timestamp":1789152112455,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Staphylococcus aureus co-infection is seldom reported in children with severe dengue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>In this retrospective study, we reported five children with severe dengue and S. aureus\u00a0co-infection admitted to pediatric intensive care unit (PICU) during July\u2013December 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All children had prolonged fever, persistence of bilateral pleural effusion beyond the critical phase, thrombocytopenia and raised inflammatory markers [C-reactive protein (CRP) and procalcitonin]. S. aureus\u00a0was isolated from pleural fluid (n\u2009=\u20092, 40%), blood (n\u2009=\u20092, 40%) and endotracheal aspirate (n\u2009=\u20091, 20%). Four children (80%) grew methicillin-sensitive S. aureus, while 1 (20%) had methicillin-resistant S. aureus. Two children (40%) had septic thromboemboli in skin, and 1 (20%) had limb cellulitis. One child required anterior thoracotomy, pericardiectomy and bilateral pleural decortication, while all other children required intercostal chest tube drainage. All children required prolonged targeted antibiotics, invasive mechanical ventilation and had prolong stay in PICU and all of them survived.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In children with severe dengue, persistence of fever, persistence of pleural effusion beyond critical phase and raised CRP and procalcitonin should raise suspicion of bacterial\/S. aureus co-infection.<\/jats:p><\/jats:sec>","DOI":"10.1093\/tropej\/fmac102","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T19:53:18Z","timestamp":1670529198000},"source":"Crossref","is-referenced-by-count":5,"title":["Severe dengue associated with<i>Staphylococcus aureus<\/i>sepsis in pediatric patients: a case series"],"prefix":"10.1093","volume":"69","author":[{"given":"K C","family":"Sudeep","sequence":"first","affiliation":[{"name":"Division of Pediatric Emergency and Intensive Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate 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