{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:47:05Z","timestamp":1790628425775,"version":"4.1.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of thrombotic microangiopathy (TMA) following snake bite is reported to be ranging from 3.6 to 15%. We report a 10-year-old boy who developed TMA and due to venom-induced consumptive coagulopathy (VICC) despite receiving adequate and timely doses of snake antivenom following a bite of saw-scaled viper (Echis carinatus sochureki). VICC was managed by plasmapheresis. Though snake bite envenomation-associated renal complications are not uncommon, possibility of TMA should be considered early during management. Our patient developed TMA with subsequent acute cortical necrosis after saw-scaled viper bite despite an adequate and timely dose of snake antivenom which emphasizes the ineffectiveness of antivenom against the venom of given snake species leading to long-term complications.<\/jats:p>","DOI":"10.1093\/tropej\/fmac113","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T17:34:10Z","timestamp":1673458450000},"source":"Crossref","is-referenced-by-count":7,"title":["Venom-induced consumptive coagulopathy leading to thrombotic microangiopathy following<i>Echis carinatus sochureki<\/i>bite: is snake antivenom effective?"],"prefix":"10.1093","volume":"69","author":[{"given":"Vivek","family":"Parihar","sequence":"first","affiliation":[{"name":"Department of Paediatrics, AIIMS , Jodhpur 342005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6404-5406","authenticated-orcid":false,"given":"Aliza","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, AIIMS , Jodhpur 342005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwajeet","family":"Vikarn","sequence":"additional","affiliation":[{"name":"Department of Pathology, AIIMS , Jodhpur 342005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyram","family":"Didel","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, AIIMS , Jodhpur 342005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeep","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, AIIMS , Jodhpur 342005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"2023011113511774600_fmac113-B1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s13643-019-1133-2","article-title":"Snakebite associated thrombotic microangiopathy: a protocol for the systematic review of clinical features, outcomes, and role of interventions","volume":"8","author":"Noutsos","year":"2019","journal-title":"Syst Rev"},{"key":"2023011113511774600_fmac113-B2","first-page":"193","article-title":"Taxonomic revision of the snake genus Echis (Viperidae). II. An analysis of taxonomy and description of new forms [in Russian]","volume":"207","author":"Cherlin","year":"1990","journal-title":"Proc Zool Inst Leningrad"},{"key":"2023011113511774600_fmac113-B3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1580\/06-WEME-OR-078R.1","article-title":"Rediscovery of severe saw-scaled viper (Echis sochureki) envenoming in the Thar Desert Region of Rajasthan, India","volume":"18","author":"Kochar","year":"2007","journal-title":"Wilderness Environ Med"},{"key":"2023011113511774600_fmac113-B4","doi-asserted-by":"crossref","first-page":"2050313X211032399","DOI":"10.1177\/2050313X211032399","article-title":"Thrombotic microangiopathy following saw-scaled viper (Echis carinatus) envenoming in Sri Lanka","volume":"9","author":"Pirasath","year":"2021","journal-title":"SAGE Open Med Case Rep"},{"key":"2023011113511774600_fmac113-B5","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1445-5994.2007.01407.x","article-title":"Thrombotic microangiopathy from Australian brown snake (Pseudonaja) envenoming","volume":"37","author":"Isbister","year":"2007","journal-title":"Intern Med J"},{"key":"2023011113511774600_fmac113-B6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/15563650.2021.1948559","article-title":"Snakebite-associated thrombotic microangiopathy: an Australian prospective cohort study [ASP30]","volume":"60","author":"Noutsos","year":"2022","journal-title":"Clin Toxicol (Phila)"},{"key":"2023011113511774600_fmac113-B7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/jca.21691","article-title":"Role of therapeutic plasma exchange in snake bite associated thrombotic microangiopathy - a case report with review of literature","volume":"34","author":"Mohan","year":"2019","journal-title":"J Clin Apher"},{"key":"2023011113511774600_fmac113-B8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jca.21705","article-title":"Guidelines on the use of therapeutic apheresis in clinical practice \u2013 evidence-based approach from the Writing Committee of the American Society for Apheresis: the Eighth Special Issue","volume":"34","author":"Padmanabhan","year":"2019","journal-title":"J Clin Apher"},{"key":"2023011113511774600_fmac113-B9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.wem.2021.01.004","article-title":"Venom-Induced Consumption Coagulopathy Unresponsive to Antivenom After Echis carinatus sochureki Envenoming","volume":"32","author":"Gopalakrishnan","year":"2021","journal-title":"Wilderness Environ Med"},{"key":"2023011113511774600_fmac113-B10","doi-asserted-by":"crossref","first-page":"100048","DOI":"10.1016\/j.toxcx.2020.100048","article-title":"Comparative proteomics of geographically distinct saw-scaled viper (Echis carinatus) venoms from India","volume":"7","author":"Bhatia","year":"2020","journal-title":"Toxicon X"},{"key":"2023011113511774600_fmac113-B11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.14712\/23362936.2016.6","article-title":"Snakebite envenoming by Sochurek\u2019s saw-scaled viper Echis carinatus sochureki","volume":"117","author":"Valenta","year":"2016","journal-title":"Prague Med Rep"}],"container-title":["Journal of Tropical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/tropej\/article-pdf\/69\/1\/fmac113\/48614717\/fmac113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/tropej\/article-pdf\/69\/1\/fmac113\/48614717\/fmac113.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T20:06:22Z","timestamp":1728590782000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/tropej\/article\/doi\/10.1093\/tropej\/fmac113\/6984706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,5]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12,5]]}},"URL":"https:\/\/doi.org\/10.1093\/tropej\/fmac113","relation":{},"ISSN":["1465-3664"],"issn-type":[{"value":"1465-3664","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,2,1]]},"published":{"date-parts":[[2022,12,5]]},"article-number":"fmac113"}}