{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:20:05Z","timestamp":1753878005261,"version":"3.41.2"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The WHO recommends preventive treatment for all pediatric contacts of a confirmed TB case, but coverage remains low in many high TB burden countries. We aimed to assess the coverage and adherence of the isoniazid preventive therapy (IPT) program among children under 5\u2009years of age with household exposure to an adult pulmonary TB case in a rural district of Southern Mozambique. The estimated IPT coverage was 11.7%. A longer distance to the health center and lower age of the children hindered IPT initiation. Among patients who started IPT, 12\/18 (69.9%) were adherent to the 6-month treatment.<\/jats:p>","DOI":"10.1093\/tropej\/fmad009","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T21:52:43Z","timestamp":1675115563000},"source":"Crossref","is-referenced-by-count":0,"title":["Initiation and adherence to isoniazid preventive therapy in children under 5 years of age in Manhi\u00e7a, Southern Mozambique"],"prefix":"10.1093","volume":"69","author":[{"given":"Agn\u00e8s","family":"Montoya i de Manuel-Rimbau","sequence":"first","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinis","family":"Nguenha","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Saude de Manhi\u00e7a , Manhi\u00e7a, Maputo, Mozambique"},{"name":"Amsterdam Institute for Global Health and Development (AIGHD) , Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson","family":"Mambuque","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Saude de Manhi\u00e7a , Manhi\u00e7a, Maputo, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilzia","family":"Munguambe","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Saude de Manhi\u00e7a , Manhi\u00e7a, Maputo, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Saavedra","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona , Barcelona, Spain"},{"name":"Centro de Investiga\u00e7\u00e3o em Saude de Manhi\u00e7a , Manhi\u00e7a, Maputo, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodimiro","family":"Matsena","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Saude de Manhi\u00e7a , Manhi\u00e7a, Maputo, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lio","family":"Chiconela","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Saude de Manhi\u00e7a , Manhi\u00e7a, Maputo, Mozambique"},{"name":"National Tuberculosis Control Programme , District of Manhi\u00e7a, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aina","family":"Casellas","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"L\u00f3pez-Varela","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona , Barcelona, Spain"},{"name":"Centro de Investiga\u00e7\u00e3o em Saude de Manhi\u00e7a , Manhi\u00e7a, Maputo, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sozinho","family":"Acacio","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Saude de Manhi\u00e7a , Manhi\u00e7a, Maputo, Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2038-5505","authenticated-orcid":false,"given":"Alberto L","family":"Garcia-Basteiro","sequence":"additional","affiliation":[{"name":"ISGlobal, Hospital Cl\u00ednic, Universitat de Barcelona , Barcelona, Spain"},{"name":"Centro de Investiga\u00e7\u00e3o em Saude de Manhi\u00e7a , Manhi\u00e7a, Maputo, Mozambique"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC) , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"year":"2018","author":"World Health Organization (WHO)","key":"2023013016130398400_fmad009-B1"},{"key":"2023013016130398400_fmad009-B2","first-page":"12","article-title":"Chapter 4: childhood contact screening and management","volume":"11","author":"World Health Organization Stop TB Partnership Childhood TB Subgroup","year":"2007","journal-title":"Int J Tuberc Lung Dis"},{"key":"2023013016130398400_fmad009-B3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2334-14-91","article-title":"Efficacy of isoniazid prophylactic therapy in prevention of tuberculosis in children: a meta-analysis","volume":"14","author":"Ayieko","year":"2014","journal-title":"BMC Infect Dis"},{"year":"2020","author":"World Health Organization (WHO)","key":"2023013016130398400_fmad009-B4"},{"year":"2018","author":"World Health Organization 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