{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:13:55Z","timestamp":1793060035412,"version":"4.5.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Faculty of Medicine Ramathibodi Hospital"},{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Southeast Asia is the endemic area of hepatitis E virus (HEV) infection. We aimed to determine the seroprevalence of the virus, its association, and the prevalence of chronic infection after pediatric liver transplantation (LT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross-sectional study was performed in Bangkok, Thailand. Patients aged &amp;lt;18\u2009years who had LT for &amp;gt;2\u2009years underwent serologic and real-time polymerase chain reaction (rt-PCR) tests. Acute HEV infection was defined by the presence of positive anti-HEV immunoglobulin (Ig)M and HEV viremia from the rt-PCR. If the viremia persisted for &amp;gt;6\u2009months, chronic HEV infection was diagnosed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 101 patients had a median age of 8.4\u2009years [interqartile range (IQR): 5.8\u201311.7]. The seroprevalence of anti-HEV IgG and IgM was 15% and 4%, respectively. Positive IgM and\/or IgG were associated with a history of elevated transaminases with an unknown cause after LT (p\u2009=\u20090.04 and p\u2009=\u20090.01, respectively). The presence of HEV IgM was associated with a history of elevated transaminases with an unknown cause within 6\u2009months (p\u2009=\u20090.01). The two patients (2%) diagnosed with chronic HEV infection did not fully respond to the reduction of immunosuppression but responded well to ribavirin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Seroprevalence of HEV among pediatric LT recipients was not rare in Southeast Asia. Since HEV seropositivity was associated with elevated transaminases of an unknown cause, investigation for the virus should be offered in LT children with hepatitis after excluding other etiologies. Pediatric LT recipients with chronic HEV infection may receive a benefit from a specific antiviral treatment.<\/jats:p><\/jats:sec>","DOI":"10.1093\/tropej\/fmad011","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T14:30:06Z","timestamp":1677076206000},"source":"Crossref","is-referenced-by-count":5,"title":["Seroprevalence of hepatitis E virus after pediatric liver transplantation"],"prefix":"10.1093","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7558-1995","authenticated-orcid":false,"given":"Songpon","family":"Getsuwan","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"},{"name":"Ramathibodi Excellence Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekawat","family":"Pasomsub","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pichet","family":"Yutthanakarnwikom","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chutatip","family":"Tongsook","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Napapat","family":"Butsriphum","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"},{"name":"Ramathibodi Excellence Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornthep","family":"Tanpowpong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"},{"name":"Ramathibodi Excellence Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pareena","family":"Janchompoo","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suporn","family":"Treepongkaruna","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"},{"name":"Ramathibodi Excellence Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chatmanee","family":"Lertudomphonwanit","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"},{"name":"Ramathibodi Excellence Center for Organ Transplantation, Faculty of Medicine Ramathibodi Hospital, Mahidol University , Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3390\/jcm9020331","article-title":"Clinical manifestations, pathogenesis and treatment of hepatitis E virus infections","volume":"9","author":"Lhomme","year":"2020","journal-title":"J Clin Med"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-981-13-0050-9_2","volume-title":"Viral Hepatitis in Children: Prevention and Management.","author":"Nelson","year":"2019"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1089\/vim.2018.0146","article-title":"A nationwide survey of the seroprevalence of hepatitis E virus infections among blood donors in Thailand","volume":"32","author":"Jupattanasin","year":"2019","journal-title":"Viral Immunol"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"e0126184","DOI":"10.1371\/journal.pone.0126184","article-title":"Swine is a possible source of hepatitis E virus infection by comparative study of hepatitis A and E seroprevalence in Thailand","volume":"10","author":"Sa-nguanmoo","year":"2015","journal-title":"PLoS One"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"721918","DOI":"10.3389\/fped.2021.721918","article-title":"Current paradigm of Hepatitis E virus among pediatric and adult patients","volume":"9","author":"Belei","year":"2021","journal-title":"Front Pediatr"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/MPG.0000000000001231","article-title":"Hepatitis E in children: a position paper by the ESPGHAN hepatology committee","volume":"63","author":"Fischler","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1136\/gutjnl-2011-300708","article-title":"Chronic hepatitis E infection in children with liver transplantation","volume":"61","author":"Halac","year":"2012","journal-title":"Gut"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1399-3046.2012.01740.x","article-title":"Prevalence of hepatitis E virus infection in pediatric solid organ transplant recipients\u2014a single-center experience","volume":"16","author":"Hoerning","year":"2012","journal-title":"Pediatr Transplant"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jcv.2015.04.022","article-title":"Paediatric liver transplanted patients and prevalence of hepatitis E virus","volume":"69","author":"Laverdure","year":"2015","journal-title":"J Clin Virol"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s10096-013-2042-2","article-title":"Hepatitis E in liver transplant recipients in the Rh\u00f4ne-Alpes region in France","volume":"33","author":"Buffaz","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.clinre.2019.06.002","article-title":"Seroprevalence of hepatitis E virus infection in children after liver transplantation: a single-center experience in France","volume":"44","author":"Nader","year":"2020","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/trf.15041","article-title":"Hepatitis E virus infection in Thai blood donors","volume":"59","author":"Intharasongkroh","year":"2019","journal-title":"Transfusion"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1099\/jmm.0.000706","article-title":"Laboratory challenges in the diagnosis of hepatitis E virus","volume":"67","author":"Al-Sadeq","year":"2018","journal-title":"J Med Microbiol"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1177\/0009922812439462","article-title":"Fever, jaundice, and liver failure in an 18-year-old male","volume":"51","author":"Tanpowpong","year":"2012","journal-title":"Clin Pediatr (Phila)"},{"key":"2023022214300279300_","first-page":"e109","article-title":"Hepatitis E virus cross-reactivity and false-seropositivity: challenges to diagnosis","volume":"3","author":"Parvez","year":"2014","journal-title":"J Liver"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"7352","DOI":"10.1038\/s41598-020-64551-x","article-title":"Clinical significance of post-liver transplant hepatitis E seropositivity in high prevalence area of hepatitis E genotype 3: a prospective study","volume":"10","author":"Komolmit","year":"2020","journal-title":"Sci Rep"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/petr.12077","article-title":"Results of single-center screening for chronic hepatitis E in children after liver transplantation and report on successful treatment with ribavirin","volume":"17","author":"Junge","year":"2013","journal-title":"Pediatr Transplant"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s12664-018-0840-2","article-title":"Absence of chronic hepatitis E virus infection in liver transplant recipients: report from a hyperendemic region","volume":"37","author":"Agarwala","year":"2018","journal-title":"Indian J Gastroenterol"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/lt.21819","article-title":"Prevalence of hepatitis E virus infection in liver transplant recipients","volume":"15","author":"Haagsma","year":"2009","journal-title":"Liver Transpl"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00428-007-0382-y","article-title":"Liver histology in patients with sporadic acute hepatitis E: a study of 11 patients from South-West France","volume":"450","author":"Peron","year":"2007","journal-title":"Virchows Arch"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1016\/j.clinre.2017.12.005","article-title":"Hepatitis E virus infection mimicking acute graft rejection in a liver transplant recipient","volume":"42","author":"Allaire","year":"2018","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.transproceed.2020.01.011","article-title":"Hepatitis E is a rare finding in liver transplant patients with chronic elevated liver enzymes and biopsy-proven acute rejection","volume":"52","author":"Darstein","year":"2020","journal-title":"Transplant Proc"},{"key":"2023022214300279300_","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12876-019-0995-z","article-title":"Sofosbuvir add-on to ribavirin for chronic hepatitis E in a cirrhotic liver transplant recipient: a case report","volume":"19","author":"Fraga","year":"2019","journal-title":"BMC Gastroenterol"}],"container-title":["Journal of Tropical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/tropej\/article-pdf\/69\/2\/fmad011\/49296585\/fmad011.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/tropej\/article-pdf\/69\/2\/fmad011\/49296585\/fmad011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T18:58:42Z","timestamp":1679770722000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/tropej\/article\/doi\/10.1093\/tropej\/fmad011\/7051074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,6]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2,6]]}},"URL":"https:\/\/doi.org\/10.1093\/tropej\/fmad011","relation":{},"ISSN":["1465-3664"],"issn-type":[{"value":"1465-3664","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,4,1]]},"published":{"date-parts":[[2023,2,6]]},"article-number":"fmad011"}}