{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:16:55Z","timestamp":1753877815076,"version":"3.41.2"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860065"],"award-info":[{"award-number":["81860065"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangxi Provincial Natural Science Funds of China","award":["20202BABL206011"],"award-info":[{"award-number":["20202BABL206011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Coronavirus disease 2019 (COVID-19) has become a significant global public health problem. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which causes the disease, utilizes angiotensin-converting enzyme II (ACE2) as a major functional receptor to enter host cells. No study has systematically assessed ACE2 expression in multiple tissues in children. This study investigated ACE2 expression and ACE2 protein\u2019s histological distribution in various organs in paediatric patients (the small intestine, thymus, heart and lungs). Our study revealed that ACE2 was highly expressed in enterocytes of the small intestine and widely expressed in the myocardium of heart tissues. The most notable finding was the positive staining of ACE2 in the Hassall\u2019s corpuscles epithelial cells. Negligible ACE2 expression in the lung tissues may contribute to a lower risk of infection and fewer symptoms of pneumonia in children than in adults with COVID-19 infection. These findings provide initial evidence for understanding SARS-CoV-2 pathogenesis and prevention strategies in paediatric clinical practice, which should be applicable for all children worldwide.<\/jats:p>","DOI":"10.1093\/tropej\/fmad027","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T05:53:21Z","timestamp":1694066001000},"source":"Crossref","is-referenced-by-count":0,"title":["Tissue expression of the SARS-CoV-2 cell receptor gene ACE2 in children"],"prefix":"10.1093","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9646-4915","authenticated-orcid":false,"given":"Jiyi","family":"Huang","sequence":"first","affiliation":[{"name":"Central Laboratory, Jiangxi Provincial Children\u2019s Hospital , Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibin","family":"Guo","sequence":"additional","affiliation":[{"name":"Central Laboratory, Jiangxi Provincial Children\u2019s Hospital , Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junkai","family":"Duan","sequence":"additional","affiliation":[{"name":"Pediatric Heart Disease Treatment Center, Jiangxi Provincial Children\u2019s Hospital , Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zou","sequence":"additional","affiliation":[{"name":"Pediatric Heart Disease Treatment Center, Jiangxi Provincial Children\u2019s Hospital , Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neonatal Surgery, Jiangxi Provincial Children\u2019s Hospital , Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jiangxi Provincial Children\u2019s Hospital , Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pediatric Heart Disease Treatment Center, Jiangxi Provincial Children\u2019s Hospital , Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunguo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Pediatric Heart Disease Treatment Center, Jiangxi Provincial Children\u2019s Hospital , Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"year":"2023","author":"World Health Organization","key":"2023090705531548000_fmad027-B1"},{"key":"2023090705531548000_fmad027-B2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, 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