{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:20:06Z","timestamp":1753878006773,"version":"3.41.2"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Congenital Zika syndrome (CZS) is a recently described disease. Our main objective was to evaluate and monitor, over 3\u2009years, the ophthalmoscopic findings in children exposed to zika virus (ZIKV) during gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective observational study was conducted in Rio de Janeiro, Brazil, between April 2016 and May 2019. We evaluated two groups with exanthema serving as a proxy for viremia: (i) children whose mothers had exanthema during pregnancy and (ii) children who had microcephaly without maternal exanthema during pregnancy. We performed indirect ophthalmoscopy at recruitment and every 6 months thereafter. We also tested the association between ocular findings with maternal exanthema, microcephaly, CZS and maternal infection confirmed by reverse transcriptase quantitative polymerase chain reaction and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 72 children included, 16 (22.2%) had optic nerve and\/or retinal lesions. All 16 had CZS and 15 (93.7%) had microcephaly (14 at birth and 1 postnatally). The child with postnatally acquired microcephaly was born to a mother without exanthema during pregnancy. Fifty-six (77.8%) of the 72 children were followed for a median time of 24\u2009months and none exhibited differences between admission and follow-up examinations. After logistic regression, only microcephaly at birth was associated with eye abnormalities (odds ratio, 77.015; 95% confidence interval, 8.85\u2013670.38; p\u2009&amp;lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed that there was no progression of the lesions over the follow-up period. We also showed that the eye findings were associated only with microcephaly at birth. Attention should be paid to all children born during a ZIKV epidemic, regardless of maternal exanthema and\/or microcephaly at birth.<\/jats:p><\/jats:sec>","DOI":"10.1093\/tropej\/fmad030","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T05:38:09Z","timestamp":1694669889000},"source":"Crossref","is-referenced-by-count":2,"title":["Evaluation and monitoring of eye findings in children exposed to Zika virus during gestation: 3 years of follow-up"],"prefix":"10.1093","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0210-7368","authenticated-orcid":false,"given":"Maria Luiza Bernardes","family":"Dos Santos","sequence":"first","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal Fluminense Rua Marqu\u00eas de Paran\u00e1, 303, Centro , Niter\u00f3i, RJ 24.033-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Cl\u00e1udio Santos De Souza","family":"Lima","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal Fluminense Rua Marqu\u00eas de Paran\u00e1, 303, Centro , Niter\u00f3i, RJ 24.033-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Ara\u00fajo","family":"Zin","sequence":"additional","affiliation":[{"name":"Instituto Fernandes Figueira, Unidade de Pesquisa Cl\u00ednica Av Rui Barbosa, 716, Flamengo , Rio de Janeiro, RJ 22.250-020, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elisabeth Lopes","family":"Moreira","sequence":"additional","affiliation":[{"name":"Instituto Fernandes Figueira, Unidade de Pesquisa Cl\u00ednica Av Rui Barbosa, 716, Flamengo , Rio de Janeiro, RJ 22.250-020, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilton Farias Moreira","family":"De Vasconcelos","sequence":"additional","affiliation":[{"name":"Instituto Fernandes Figueira, Unidade de Pesquisa Cl\u00ednica Av Rui Barbosa, 716, Flamengo , Rio de Janeiro, RJ 22.250-020, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiza Maceira De Almeida","family":"Neves","sequence":"additional","affiliation":[{"name":"Instituto Fernandes Figueira, Unidade de Pesquisa Cl\u00ednica Av Rui Barbosa, 716, Flamengo , Rio de Janeiro, RJ 22.250-020, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio Bastos","family":"Pereira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal Fluminense Rua Marqu\u00eas de Paran\u00e1, 303, Centro , Niter\u00f3i, RJ 24.033-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata Artimos De Oliveira","family":"Vianna","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal Fluminense Rua Marqu\u00eas de Paran\u00e1, 303, Centro , Niter\u00f3i, RJ 24.033-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Guillermo Coca","family":"Velarde","sequence":"additional","affiliation":[{"name":"Instituto de Matem\u00e1tica e Estat\u00edstica, Universidade Federal Fluminense Rua M\u00e1rio Santos Braga, s\/n, Centro , Niter\u00f3i, RJ 24.020-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solange Artimos","family":"De Oliveira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal Fluminense Rua Marqu\u00eas de Paran\u00e1, 303, Centro , Niter\u00f3i, RJ 24.033-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee Woodland","family":"Riley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Vaccinology, University of California , Berkeley, CA 94720, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudete Aparecida Ara\u00fajo","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Federal Fluminense Rua Marqu\u00eas de Paran\u00e1, 303, Centro , Niter\u00f3i, RJ 24.033-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"2023091404594544700_fmad030-B1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika virus (I). 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