{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:24:53Z","timestamp":1793201093761,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Malaria is a significant cause of morbidity and mortality in adults and children. Plasmodium falciparum is the primary cause of severe malaria, but recently Plasmodium vivax is also recognized to cause severe malaria-associated morbidity and mortality. The study focuses on determining the mortality related to severity parameters in individuals under 12\u2009years and their critical presentation in P.vivax malaria-infected children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective cross-sectional hospital-based study was conducted at Safdarjung Hospital, New Delhi, and ICMR-NIMR, New Delhi. All clinically suspected cases were admitted for screening. Exclusion criteria (rapid malaria antigen test, microscopy and medication history) were applied to all the admitted patients (n\u2009=\u2009221) to obtain P.vivax patients only. Patients aged \u2264\u200912\u2009years were included in the study. DNA was extracted from dried blood spots and amplified by nested PCR, followed by visualization on gel electrophoresis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Result<\/jats:title>\n                  <jats:p>A total of 221 clinically suspected cases of malaria were screened for P.vivax. After implementing various exclusion criteria, 45\/221 cases were enrolled for the study, among which 44.4% (20\/45) of children had the symptoms of severe malaria in terms of cerebral malaria, thrombocytopenia, anemia, pancytopenia, acute respiratory distress syndrome and hemophagocytic lymphohistiocytosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Plasmodium vivax mono-infection can cause severe manifestation and must be treated as P.falciparum without any delay because it may lead to increased morbidity and mortality. A changing trend in clinical symptoms has shown in P.vivax which was an earlier phenomenon of P.falciparum.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmad034","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T11:03:15Z","timestamp":1697886195000},"source":"Crossref","is-referenced-by-count":5,"title":["Trends in clinical features and severity of <i>Plasmodium vivax<\/i> malaria among children at tertiary care center in North India"],"prefix":"10.1093","volume":"69","author":[{"given":"Aditi","family":"Arya","sequence":"first","affiliation":[{"name":"Cell Biology Laboratory and Malaria Parasite Bank, ICMR-National Institute of Malaria Research , New Delhi 110077, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5147-1820","authenticated-orcid":false,"given":"Shyam Sundar","family":"Meena","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, VMMC, 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