{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:20:07Z","timestamp":1753878007202,"version":"3.41.2"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Catholic University of Health and Allied Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,5]]},"abstract":"<jats:title>\u2003<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Uncertainty exists regarding the ideal interval between the administration of antenatal corticosteroids (ACS) and delivery. The study\u2019s objective was to assess the risks of perinatal mortality and respiratory distress syndrome (RDS) among preterm neonates whose mothers gave birth within 48\u2009h of the administration of ACS and those whose mothers gave birth between 48\u2009h and 7\u2009days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The study design was a secondary analysis of data from an observational prospective chart review study that was carried out in Tanzania in 2020. Preterm infants born to mothers who got at least one dose of ACS between 28 and 34\u2009weeks of pregnancy were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 346 preterm neonates (294 singletons and 52 twins) were exposed to ACS. Compared to infants born 48\u2009h following the first dose of ACS, those exposed to the drug between 48\u2009h and 7\u2009days had significantly decreased rates of perinatal mortality and RDS. Multivariable analysis revealed that infants exposed ACS between 48\u2009h and 7\u2009days prior to delivery had lower risk of perinatal mortality (aRR 0.30, 95% CI 0.14\u20130.66) and RDS (aRR 0.27, 95% CI 0.14\u20130.52).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The first dose of ACS given between 48\u2009h and 7\u2009days before delivery was associated with a lower risk of perinatal mortality and RDS than when the first dose was given &amp;lt;48\u2009h before delivery. To improve neonatal outcomes, healthcare providers should consider administering ACS to mothers at the appropriate time.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmad037","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T17:23:15Z","timestamp":1700673795000},"source":"Crossref","is-referenced-by-count":0,"title":["Antenatal corticosteroid therapy, delivery intervals and perinatal mortality in low-resource settings"],"prefix":"10.1093","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0563-6705","authenticated-orcid":false,"given":"Stanley","family":"Mwita","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics and Pharmacy Practice, Catholic University of Health and Allied Sciences , Mwanza 33109, Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Kamala","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, 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