{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:20:10Z","timestamp":1779308410599,"version":"3.51.4"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>BACKGROUND<\/jats:title>\n                  <jats:p>Pulse oximetry is commonly used to monitor arterial oxygen saturation and heart rate during the transition period and reference intervals have been determined. However, the effect of the change in arterial oxygen saturation on tissue oxygenation does not seem to be the same. So, a non-invasive method for monitoring cerebral or regional tissue oxygenation will be potentially useful for vulnerable infants. This study aims to evaluate the effectiveness of cerebral autoregulation in the first 10\u2009min after delivery in term and late preterm newborns without resuscitation requirement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>METHODS<\/jats:title>\n                  <jats:p>Cerebral tissue oxygen saturation was measured in the first 10\u2009min after birth with near-infrared spectroscopy (NIRS) from the left forehead. Peripheral oxygen saturation was measured with pulse oximetry from the right hand and cerebral fractional tissue oxygen extraction was calculated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Nineteen late preterms and 20 term infants were included in the study. There was no statistically significant difference between median cerebral tissue oxygen saturation and cerebral fractional tissue oxygen extraction values of late preterm and term infants (p\u2009&amp;lt;\u20090.001). There was a strong inverse relationship between cerebral tissue oxygen saturation and cerebral fractional tissue oxygen extraction (p\u2009&amp;lt;\u20090.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>In late preterm infants similar to term infants, arterial oxygen saturation and cerebral tissue oxygen saturation increased with time, but inverse reduction of cerebral fractional tissue oxygen extraction showed the presence of an active autoregulation in the brain. This can be interpreted as the ability of the brain to protect itself from hypoxia by regulating oxygen uptake during normal fetal-neonatal transition process. A larger scale multi-center randomized control trial is now needed to further inform practice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmae004","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T23:21:02Z","timestamp":1710544862000},"source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of cerebral autoregulation of oxygen by NIRS method during postnatal transition period in term and late preterm newborns without resuscitation requirement"],"prefix":"10.1093","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7846-7634","authenticated-orcid":false,"given":"Omer","family":"Ertekin","sequence":"first","affiliation":[{"name":"Neonatology Unit, Health Sciences University, Ankara Bilkent City Hospital, \u00c7ankaya , Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8937-4671","authenticated-orcid":false,"given":"Mehmet","family":"Buyuktiryaki","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Health Sciences University, Ankara Bilkent City Hospital, \u00c7ankaya , Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-059X","authenticated-orcid":false,"given":"Sehribanu","family":"Isik","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Health Sciences University, Ankara Bilkent City Hospital, \u00c7ankaya , Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0027-0532","authenticated-orcid":false,"given":"Nilufer","family":"Okur","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Health Sciences University, Ankara Bilkent City Hospital, \u00c7ankaya , Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serife Suna","family":"Oguz","sequence":"additional","affiliation":[{"name":"Neonatology Unit, Health Sciences University, Ankara Bilkent City Hospital, \u00c7ankaya , Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"2024031523205941200_fmae004-B1","first-page":"339","article-title":"Cerebral, renal, and splanchnic tissue oxygen saturation values in healthy term newborns","volume":"31","author":"Bailey","year":"2014","journal-title":"Am J Perinatol"},{"key":"2024031523205941200_fmae004-B2","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.resuscitation.2012.12.025","article-title":"aEEG and NIRS during transition and resuscitation after birth: promising additional tools; an observational study","volume":"84","author":"Pichler","year":"2013","journal-title":"Resuscitation"},{"key":"2024031523205941200_fmae004-B3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000357162","article-title":"How to monitor the brain during immediate neonatal transition and resuscitation? A systematic qualitative review of the literature","volume":"105","author":"Pichler","year":"2014","journal-title":"Neonatology"},{"key":"2024031523205941200_fmae004-B4","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jpeds.2009.09.050","article-title":"Near-infrared spectroscopy measurements of cerebral oxygenation in newborns during immediate postnatal adaptation","volume":"156","author":"Fauchere","year":"2010","journal-title":"J Pediatr"},{"key":"2024031523205941200_fmae004-B5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1161\/01.STR.4.6.917","article-title":"Autoregulation and hyperemia of cerebral blood flow as evaluated by thermal diffusion","volume":"4","author":"Carter","year":"1973","journal-title":"Stroke"},{"key":"2024031523205941200_fmae004-B6","first-page":"240","article-title":"Coupling of brain activity and cerebral blood flow: basis of functional neuroimaging","volume":"7","author":"Villringer","year":"1995","journal-title":"Cerebrovasc Brain Met"},{"key":"2024031523205941200_fmae004-B7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.earlhumdev.2005.07.004","article-title":"Fetal and neonatal origins of altered brain development","volume":"81","author":"Rees","year":"2005","journal-title":"Early Hum Dev"},{"key":"2024031523205941200_fmae004-B8","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/archdischild-2012-301778","article-title":"Quantitative cranial ultrasound prediction of severity of disability in premature infants with posthaemorrhagic ventricular dilatation","volume":"97","author":"Jary","year":"2012","journal-title":"Arch Dis Child"},{"key":"2024031523205941200_fmae004-B9","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s00381-012-1897-3","article-title":"Impact of low-grade intraventricular hemorrhage on long-term neurodevelopmental outcome in preterm infants","volume":"28","author":"Klebermass-Schrehof","year":"2012","journal-title":"Childs Nerv Syst"},{"issue":"Suppl. 1","key":"2024031523205941200_fmae004-B10","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0049-3848(13)70018-5","article-title":"Intraventricular hemorrhage in preterm infants and coagulation\u2014ambivalent perspectives?","volume":"131","author":"Kuperman","year":"2013","journal-title":"Thromb Res"},{"key":"2024031523205941200_fmae004-B11","doi-asserted-by":"crossref","first-page":"e1340","DOI":"10.1542\/peds.2009-1510","article-title":"Defining the reference range for oxygen saturation for infants after birth","volume":"125","author":"Dawson","year":"2013","journal-title":"Pediatrics"},{"key":"2024031523205941200_fmae004-B12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.siny.2010.03.004","article-title":"Monitoring oxygen saturation and heart rate in the early neonatal period","volume":"15","author":"Dawson","year":"2010","journal-title":"Semin Fetal Neonatal Med"},{"key":"2024031523205941200_fmae004-B13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000151642","article-title":"Monitoring neonatal regional cerebral oxygen saturation in clinical practice: value and pitfalls","volume":"94","author":"van Bel","year":"2008","journal-title":"Neonatology"},{"key":"2024031523205941200_fmae004-B14","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3109\/14767058.2010.511335","article-title":"Noninvasive evaluation of splanchnic tissue oxygenation using near-infrared spectroscopy in preterm neonates","volume":"24","author":"Cortez","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2024031523205941200_fmae004-B15","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1213\/ANE.0b013e31826dd6a6","article-title":"Review article: cerebral near-infrared spectroscopy in adults: a work in progress","volume":"115","author":"Ghosh","year":"2012","journal-title":"Anesth Analg"},{"key":"2024031523205941200_fmae004-B16","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.jpeds.2013.07.007","article-title":"Reference ranges for regional cerebral tissue oxygen saturation and fractional oxygen extraction in neonates during immediate transition after birth","volume":"163","author":"Pichler","year":"2013","journal-title":"J Pediatr"},{"key":"2024031523205941200_fmae004-B17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000243992","article-title":"Resuscitation of the very immature infant: cerebral Doppler flow velocities in the first 20 minutes of life","volume":"64","author":"Jorch","year":"1993","journal-title":"Biol Neonate"},{"key":"2024031523205941200_fmae004-B18","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.jpeds.2007.05.002","article-title":"Differences in mortality between late preterm and term singleton infants in the United States","volume":"151","author":"Tomashek","year":"2007","journal-title":"J Pediatr"},{"key":"2024031523205941200_fmae004-B19","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/sj.jp.7211850","article-title":"Resuscitative procedures at birth in late preterm newborns","volume":"27","author":"De Almeida","year":"2007","journal-title":"J Perinatol"},{"key":"2024031523205941200_fmae004-B20","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1542\/peds.114.2.372","article-title":"Clinical outcomes of near-term newborns","volume":"114","author":"Wang","year":"2004","journal-title":"Pediatrics"},{"key":"2024031523205941200_fmae004-B21","doi-asserted-by":"crossref","first-page":"e223","DOI":"10.1542\/peds.2006-3629","article-title":"Effect of late-preterm birth and maternal medical conditions on newborn morbidity risk","volume":"121","author":"Shapiro-Mendoza","year":"2008","journal-title":"Pediatrics"},{"key":"2024031523205941200_fmae004-B22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.clp.2013.07.003","article-title":"Neuropathologic studies of the encephalopathy of prematurity in the late preterm infant","volume":"40","author":"Haynes","year":"2013","journal-title":"Clin Perinatol"},{"key":"2024031523205941200_fmae004-B23","first-page":"1","volume-title":"Neonatal Res\u00fcsitasyon Program\u0131 Yenido\u011fan Canland\u0131rmas\u0131","author":"Yal\u00e7\u0131n","year":"2021"},{"key":"2024031523205941200_fmae004-B24","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jpeds.2012.09.038","article-title":"Cerebral oxygenation, extraction, and autoregulation in very preterm infants who develop peri-intraventricular hemorrhage","volume":"162","author":"Alderliesten","year":"2013","journal-title":"J Pediatr"},{"key":"2024031523205941200_fmae004-B25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jpeds.2011.02.030","article-title":"Regional oxygen saturation of the brain during birth transition of term infants: comparison between ceseraen and vaginal deliveries","volume":"159","author":"Urlesberger","year":"2011","journal-title":"J Pediatr"},{"key":"2024031523205941200_fmae004-B26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.anpedi.2014.01.026","article-title":"Corticoterapia prenatal y morbimortalidad del prematuro tard\u00edo: estudio prospectivo [Antenatal corticosteroid therapy and late preterm infant morbidity and mortality]","volume":"81","author":"G\u00e1zquez Serrano","year":"2014","journal-title":"An Pediatr (Barc)"},{"key":"2024031523205941200_fmae004-B27","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0006-8993(82)91057-5","article-title":"Preservation of cerebral autoregulation in the unanesthetized hypoxic newborn dog","volume":"241","author":"Camp","year":"1982","journal-title":"Brain Res"},{"key":"2024031523205941200_fmae004-B28","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.jpedsurg.2015.04.004","article-title":"Cerebral, renal and mesenteric regional oxygen saturation of term infants during transition","volume":"50","author":"Montaldo","year":"2015","journal-title":"J Pediatr Surg"},{"key":"2024031523205941200_fmae004-B29","doi-asserted-by":"crossref","first-page":"101079","DOI":"10.1016\/j.siny.2020.101079","article-title":"NIRS in the fetal to neonatal transition and immediate postnatal period","volume":"25","author":"Bruckner","year":"2020","journal-title":"Semin Fetal Neonatal Med"},{"key":"2024031523205941200_fmae004-B30","doi-asserted-by":"crossref","first-page":"e072313","DOI":"10.1136\/bmj-2022-072313","article-title":"Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial","volume":"380","author":"Pichler","year":"2023","journal-title":"BMJ"}],"container-title":["Journal of Tropical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/tropej\/article-pdf\/70\/2\/fmae004\/56991592\/fmae004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/tropej\/article-pdf\/70\/2\/fmae004\/56991592\/fmae004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T23:21:12Z","timestamp":1710544872000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/tropej\/article\/doi\/10.1093\/tropej\/fmae004\/7630160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,7]]}},"URL":"https:\/\/doi.org\/10.1093\/tropej\/fmae004","relation":{},"ISSN":["0142-6338","1465-3664"],"issn-type":[{"value":"0142-6338","type":"print"},{"value":"1465-3664","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,4,1]]},"published":{"date-parts":[[2024,2,7]]},"article-number":"fmae004"}}