{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:50:22Z","timestamp":1787629822221,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T00:00:00Z","timestamp":1720828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Tianjin Science and Technology Plan","award":["22JCQNJC01020"],"award-info":[{"award-number":["22JCQNJC01020"]}]},{"name":"Tianjin Health Research Project","award":["TJWJ2023QN083"],"award-info":[{"award-number":["TJWJ2023QN083"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cathepsin G (CTSG) plays an important role in the regulation of immune processes. Accumulated studies show that CTSG is involved in the onset and development of type 1 diabetes mellitus (T1DM). As the genetic background of T1DM varies widely among populations, we aimed to study the relationship between genetic polymorphisms in CTSG and T1DM susceptibility in Chinese populations. A total of 141 patients with T1DM and 200 healthy controls were enrolled in the study. Serum CTSG expression was detected using enzyme-linked immunosorbent assay (ELISA). Genotyping of two selected single nucleotide polymorphisms (SNPs) (rs2236742 and rs2070697) of CTSG was performed using PCR and Sanger sequencing. CTSG expression in patients with T1DM was significantly higher than in the control group. Alleles C and T of CTSG SNP rs2236742 were increased in T1DM. No significant associations were found for the SNP rs2070697. Our results indicate that the CTSG rs2236742 allele (C\/T) is associated with T1DM in Chinese children and may serve as a new biomarker for predicting T1DM susceptibility.<\/jats:p>","DOI":"10.1093\/tropej\/fmae017","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T01:21:00Z","timestamp":1723252860000},"source":"Crossref","is-referenced-by-count":4,"title":["CTSG polymorphisms in Chinese children with type 1 diabetes mellitus"],"prefix":"10.1093","volume":"70","author":[{"given":"Jiaci","family":"Li","sequence":"first","affiliation":[{"name":"Tianjin Children\u2019s Hospital (Children\u2019s Hospital, Tianjin University) , Tianjin, 300074, China"},{"name":"Tianjin Pediatric Research Institute , Tianjin, 300074, China"},{"name":"Tianjin Key Laboratory of Birth Defects for Prevention and Treatment , Tianjin, 300074, 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Medical University , Tianjin, 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Cai","sequence":"additional","affiliation":[{"name":"Tianjin Children\u2019s Hospital (Children\u2019s Hospital, Tianjin University) , Tianjin, 300074, China"},{"name":"Medical College of Tianjin University , Tianjin, 300072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Chen","sequence":"additional","affiliation":[{"name":"Tianjin Children\u2019s Hospital (Children\u2019s Hospital, Tianjin University) , Tianjin, 300074, China"},{"name":"Graduate College of Tianjin Medical University , Tianjin, 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Dong","sequence":"additional","affiliation":[{"name":"Tianjin Children\u2019s Hospital (Children\u2019s Hospital, Tianjin University) , Tianjin, 300074, China"},{"name":"Graduate College of Tianjin Medical University , Tianjin, 300070, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Children\u2019s Hospital (Children\u2019s Hospital, Tianjin University) , Tianjin, 300074, China"},{"name":"Tianjin Pediatric Research Institute , Tianjin, 300074, China"},{"name":"Tianjin Key Laboratory of Birth Defects for Prevention and Treatment , Tianjin, 300074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Shu","sequence":"additional","affiliation":[{"name":"Tianjin Children\u2019s Hospital (Children\u2019s Hospital, Tianjin University) , Tianjin, 300074, China"},{"name":"Tianjin Pediatric Research Institute , Tianjin, 300074, China"},{"name":"Tianjin Key Laboratory of Birth Defects for Prevention and Treatment , Tianjin, 300074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Lv","sequence":"additional","affiliation":[{"name":"Tianjin 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