{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:33:42Z","timestamp":1793392422472,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hypoxic-ischaemic encephalopathy (HIE) is a major cause of mortality and neurodevelopmental disability, especially in low-income countries. While therapeutic hypothermia has been shown to reduce morbidity and mortality in infants with HIE, some clinical trials in low-income countries have reported an increase in the risk of mortality. We conducted a systematic review and meta-analysis of all randomized and quasi-randomized controlled trials conducted in low-income and lower-middle-income countries that compared cooling therapy with standard care for HIE. Our primary outcome was composite of neonatal mortality and neurodevelopmental disability at 6 months or beyond. The review was registered with PROSPERO (CRD42022352728). Our review included 11 randomized controlled trials with 1324 infants with HIE. The composite of death or disability at 6 months or beyond was lower in therapeutic hypothermia group (RR 0.78, 95% CI 0.66\u20130.92, I2 = 85%). Neonatal mortality rate did not differ significantly between cooling therapy and standard care (RR 0.92, 95% CI 0.76\u20131.13, I2 = 61%). Additionally, the cooled group exhibited significantly lower rates of neurodevelopmental disability at or beyond 6 months (RR 0.34, 95%CI 0.22\u20130.52, I2 = 0%). Our analysis found that neonatal mortality rate did not differ between cooled and noncooled infants in low- and lower-middle-income countries. Cooling may have a beneficial effect on neurodevelopmental disability and the composite of death or disability at 6 months or beyond.<\/jats:p>","DOI":"10.1093\/tropej\/fmae019","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:01:33Z","timestamp":1723852893000},"source":"Crossref","is-referenced-by-count":11,"title":["Therapeutic hypothermia for neonates with hypoxic-ischaemic encephalopathy in low- and lower-middle-income countries: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-8606","authenticated-orcid":false,"given":"Raj","family":"Prakash","sequence":"first","affiliation":[{"name":"Department of Neonatology, Northern Care Alliance NHS Trust , Royal Oldham Hospital , Manchester, OL1 2JH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Ver\u00f3nica Reyes-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women\u2019s and Reproductive Health, University of Oxford, Women\u2019s Centre, John Radcliffe Hospital , Oxford, OX3 9DU, United Kingdom"},{"name":"Department of Neonatology, National Institute of Perinatology \u201cIsidro Espinosa de los Reyes\u201d , Mexico City 11000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjana","family":"Somanath Hansoge","sequence":"additional","affiliation":[{"name":"Department of Neonatology, All India Institute of Medical Sciences , Mangalagiri, Andhra Pradesh, 522503, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted S","family":"Rosenkrantz","sequence":"additional","affiliation":[{"name":"Department Paediatrics and Obstetrics, University of Connecticut School of Medicine , Farmington, CT 06030, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"2024081700001483200_fmae019-B1","author":"WHO","year":"2020"},{"key":"2024081700001483200_fmae019-B2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S2352-4642(21)00311-4","article-title":"Global, regional, and national causes of under-5 mortality in 2000\u201319: an updated systematic analysis with implications for the sustainable development goals","volume":"6","author":"Perin","year":"2022","journal-title":"Lancet Child Adolesc Health"},{"key":"2024081700001483200_fmae019-B3","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003311.pub3","article-title":"Cooling for newborns with hypoxic ischaemic encephalopathy","author":"Jacobs","year":"2013","journal-title":"Cochrane Database Syst 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