{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:01:16Z","timestamp":1791489676660,"version":"4.3.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Scrub typhus meningoencephalitis (STME) is an uncommon but fatal complication of scrub typhus that requires extra diligence in early identification and treatment. The goal of this study was to look at the clinical characteristics, laboratory results, and outcome of STME in children. A retrospective study was conducted in the paediatric intensive care unit of a tertiary care hospital in Eastern India between April 2021 and September 2022. It was carried out in children aged 1\u2009month\u201312\u2009years. Sixteen children were diagnosed with STME out of 75 acute encephalitis syndrome (AES) cases. The male-to-female ratio was 3:1, with a mean age of 4.28\u2009\u00b1\u20093.36\u2009years. All the children hailed from rural areas. Fever (100%), convulsions (87.5), altered sensorium (93.75%), nuchal stiffness (25%), vomiting (75%), pallor (75%), and hepatomegaly (50%) were the most prevalent clinical manifestations. The average duration of fever upon presentation was 8.25\u2009\u00b1\u20092.11\u2009days and the average length of hospital stay was 9.00\u2009\u00b1\u20094.59\u2009days. The complications encountered were shock (3), interstitial pneumonia (1), myocarditis (1), raised intracranial pressure (1), and right-sided hemiplegia (1). Fifteen children recovered completely, whereas one child suffered from residual right-sided neurodeficit. A high index of suspicion needs to be maintained for STME as a possible AES entity, as anti-scrub measures administered promptly can go a long way in mitigating the related morbidity and mortality especially in resource-constrained settings.<\/jats:p>","DOI":"10.1093\/tropej\/fmae031","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:20Z","timestamp":1727827220000},"source":"Crossref","is-referenced-by-count":1,"title":["Scrub typhus meningoencephalitis in children: an experience from Eastern India"],"prefix":"10.1093","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2689-6904","authenticated-orcid":false,"given":"Jadab Kumar","family":"Jana","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Bankura Sammilani Medical College and Hospital , Lokpur 722102, Bankura, West Bengal,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5467-6714","authenticated-orcid":false,"given":"Anusree Krishna","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Bankura Sammilani Medical College and Hospital , Lokpur 722102, Bankura, West Bengal,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourav","family":"Pati","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Bankura Sammilani Medical College and Hospital , Lokpur 722102, Bankura, West Bengal,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Gayen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Bankura Sammilani Medical College and Hospital , Lokpur 722102, Bankura, West Bengal,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"2024100200010461100_fmae031-B1","doi-asserted-by":"publisher","first-page":"622","DOI":"10.4269\/ajtmh.20-1019","article-title":"Analysis of 262 children with scrub typhus infection: a single-center experience","volume":"104","author":"Kispotta","year":"2020","journal-title":"Am J Trop Med Hyg"},{"key":"2024100200010461100_fmae031-B2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijid.2014.02.009","article-title":"Clinical profile and improving mortality trend of scrub typhus in South India","volume":"23","author":"Varghese","year":"2014","journal-title":"Int J Infect Dis"},{"key":"2024100200010461100_fmae031-B3","doi-asserted-by":"crossref","first-page":"e0006062","DOI":"10.1371\/journal.pntd.0006062","article-title":"A review of the global epidemiology of scrub typhus","volume":"11","author":"Xu","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"2024100200010461100_fmae031-B4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4103\/0019-557X.85239","article-title":"Emergence of Schoengastiella ligula as the vector of scrub typhus outbreak in Darjeeling: has Leptotrombidium deliense been replaced?","volume":"55","author":"Tilak","year":"2011","journal-title":"Indian J Public Health"},{"key":"2024100200010461100_fmae031-B5","first-page":"394","article-title":"Scrub typhus: an emerging scourge","volume":"9","author":"Chauhan","year":"2015","journal-title":"Indian J Basic Appl Med Res"},{"key":"2024100200010461100_fmae031-B6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4103\/0019-557X.146299","article-title":"Scrub typhus\u2014an emerging entity. 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