{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T10:11:42Z","timestamp":1775902302139,"version":"3.50.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acute kidney injury (AKI) is one of the frequently observed complications in neonates with severe perinatal asphyxia. The efficacy of aminophylline in preventing or alleviating renal dysfunction in these neonates remains controversial. The current study aimed to explore whether treatment with aminophylline as adjunctive therapy is superior to standard care alone in preventing AKI in severely asphyxiated term neonates and to delineate the changes in other renal parameters. In this open-label randomized clinical trial, term neonates with severe asphyxia (n\u2009=\u200941) received a 5\u2009mg\/kg intravenous dose of aminophylline within the first hour after birth, in addition to standard care for birth asphyxia. The control group (n\u2009=\u200940) received standard care alone. Their daily urine output, weight, serum creatinine, renal functional status, and complications during the first 5\u2009days of life were monitored and compared. The statistical package for social sciences version 25 was used for analysis. Approximately 24.39% of neonates in the aminophylline group developed AKI, compared to 35.0% in the control group (P\u2009=\u2009.088). Although urine output was generally higher in aminophylline-treated newborns than in the control group, this increase was not statistically significant (P\u2009&amp;gt;\u2009.05), with the most notable differences observed on the second and third postnatal days. Also, the changes in plasma creatinine levels between the two groups during this time were not statistically significant. Administering a single dose of aminophylline (5\u2009mg\/kg) within the first hour of life to severely asphyxiated term neonates might temporarily enhance urine output, but does not reduce the overall incidence of AKI.<\/jats:p>","DOI":"10.1093\/tropej\/fmae036","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T06:12:25Z","timestamp":1728627145000},"source":"Crossref","is-referenced-by-count":1,"title":["Role of aminophylline in prevention of acute kidney injury in term neonates with severe perinatal asphyxia: a randomized open-label controlled trial"],"prefix":"10.1093","volume":"70","author":[{"given":"Dinesh","family":"Munian","sequence":"first","affiliation":[{"name":"Department of Neonatology, Medical College and Hospital , Kolkata, West Bengal 700073,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukanta","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Medical 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