{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:08:59Z","timestamp":1788476939617,"version":"build-2803163510"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The clinical profile and outcomes of children with chikungunya infection differ from those observed in adults. As there is a paucity of data on chikungunya infection in children, this study aimed to find the clinical course, complications, and mortality rates of chikungunya infection in children. This was a combined retrospective and prospective observational study. Children aged 1 month to 15\u2009years who tested positive for chikungunya infection by IgM enzyme-linked immunosorbent assay and reverse transcription polymerase chain reaction in serum or body fluids were included. The demographic details, clinical presentation, laboratory parameters, treatment given, and outcomes were recorded in a structured proforma. Fifty-eight cases (41 retrospective and 17 prospective) were recruited, out of which 30 (52%) were males. The median age was 8 (3\u201311) years. The most common clinical feature at admission was fever observed in 55 patients (94.8%), followed by vomiting [25 (43.1%)] and myalgia [23 (39.7%)]. Commonly observed clinical signs were skin rash [32 (55.2%)], hepatomegaly [25 (43.1%)], and anemia [22 (37.9%)]. Frequently observed acute complications were lymphopenia [46 (79.3%)], hyponatremia [32 (55.2%)], capillary leak [27 (46.6%)], and thrombocytopenia [26 (44.8%)]. Of 58 cases, 8 (13.8%) children had co-infection with other microbes. Overall, 55 (94.8%) children had complete recovery, 2 (3.4%) children died of complications (one with acute encephalitis and one child with acute respiratory distress syndrome), and 5 children had prolonged arthralgia. Children with chikungunya had more skin manifestations and neurological manifestations than arthralgia. Also, a significant proportion of children developed serious complications like a capillary leak.<\/jats:p>","DOI":"10.1093\/tropej\/fmae057","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T12:16:37Z","timestamp":1735906597000},"source":"Crossref","is-referenced-by-count":8,"title":["Chikungunya infection in children: clinical profile and outcome"],"prefix":"10.1093","volume":"71","author":[{"given":"Korra Dhanunjaya","family":"Naik","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry 605006,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-8423","authenticated-orcid":false,"given":"C G","family":"Delhi Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry 605006,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0490-8211","authenticated-orcid":false,"given":"Anitha","family":"Abimannane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry 605006,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Dhodapkar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry 605006,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niranjan","family":"Biswal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) , Puducherry 605006,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"2025011404235144500_fmae057-B1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3390\/v11030294","article-title":"Chikungunya in infants and children: is pathogenesis increasing?","volume":"11","author":"Barr","year":"2019","journal-title":"Viruses"},{"key":"2025011404235144500_fmae057-B2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1080\/20477724.2018.1478777","article-title":"Chikungunya fever: a threat to global public health","volume":"112","author":"Moiz\u00e9is","year":"2018","journal-title":"Pathog Glob Health"},{"key":"2025011404235144500_fmae057-B3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/MOP.0000000000001229","article-title":"Dengue, chikungunya and zika arbovirus infections in Caribbean children","volume":"35","author":"Christie","year":"2023","journal-title":"Curr Opin Pediatr"},{"key":"2025011404235144500_fmae057-B4","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.3201\/eid2409.180330","article-title":"Severe manifestations of chikungunya fever in children, India, 2016","volume":"24","author":"Sharma","year":"2018","journal-title":"Emerg Infect Dis"},{"key":"2025011404235144500_fmae057-B5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s13312-017-1040-3","article-title":"Neurological manifestations of chikungunya in children","volume":"54","author":"Singh","year":"2017","journal-title":"Indian Pediatr"},{"key":"2025011404235144500_fmae057-B6","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/PEC.0000000000001529","article-title":"Chikungunya in children: a clinical review","volume":"34","author":"Ward","year":"2018","journal-title":"Pediatr Emerg Care"},{"key":"2025011404235144500_fmae057-B7","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s12098-018-2794-x","article-title":"Dengue and chikungunya infections in children: guest editor: Bhim S. 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