{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T04:02:11Z","timestamp":1751601731115,"version":"3.41.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Vaccine-preventable diseases (VPD) account for a major proportion of childhood morbidity and mortality in developing countries. This study aimed to evaluate the seroprotection status of common VPD in children with type 1 diabetes mellitus (T1DM). The study enrolled 38 children aged 3\u201318\u2009years with T1DM and 40 age-and sex-matched healthy controls. Demographic and clinical parameters were recorded. Venous blood samples were collected to estimate glycated hemoglobin (HbA1c) and antibody titers against hepatitis B and measles, mumps, and rubella (MMR). Both groups had completed immunization for these diseases by 2\u2009years of age. The median age was 9.5\u2009years with mean (SD) HbA1c 11.41 (2.57) %. Adequate seroprotection against hepatitis B, MMR were 42.5%, 32.5%, 50%, and 65% in T1DM, respectively and 55%, 50%, 40%, 65% in controls, respectively (P\u2009&amp;gt;\u2009.05). The median (first and third quartile) antibody levels for hepatitis B and measles in T1DM were 4.32 (0, 113.67) mIU\/l and 127.4 (44.78, 347.68) mIU\/l, respectively, both below the seroprotection cut-offs and lower than in controls (P\u2009&amp;gt;\u20090.05). The correlation (r) of age with anti-measles, antimumps, and antirubella antibody titers was 0.326 (P\u2009=\u20090.040), 0.096 (P\u2009=\u20090.554), and 0.334 (P\u2009=\u20090.035), respectively, in the cases. Anti-Hepatitis B titers correlated negatively with age (r = \u22120.287, P\u2009=\u2009.072). Lower seroprotection (statistically insignificant) to hepatitis B and measles were observed in children with T1DM than in controls. Physicians should consider surveillance of hepatitis B and measles, mumps, and rubella seroprotection in T1DM to evaluate the need for further boosters. Larger and more robust studies are needed on seroprotection in patients with T1DM.<\/jats:p>","DOI":"10.1093\/tropej\/fmaf026","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:08:52Z","timestamp":1751515732000},"source":"Crossref","is-referenced-by-count":0,"title":["Seroprotection against hepatitis B, measles, mumps, and rubella in children with diabetes"],"prefix":"10.1093","volume":"71","author":[{"given":"Maruti","family":"Haranalli","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital , New Delhi 110002,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3141-2812","authenticated-orcid":false,"given":"Sangeeta","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital , New Delhi 110002,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1768-060X","authenticated-orcid":false,"given":"Aashima","family":"Dabas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital , New Delhi 110002,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Manchanda","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Maulana Azad Medical College and Lok Nayak Hospital , New Delhi 110002,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"2025070300084789400_fmaf026-B1","author":"Ministry of Health and Family Welfare, Government of India (March 2022)"},{"key":"2025070300084789400_fmaf026-B2","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.4161\/hv.25426","article-title":"Antibody levels against hepatitis B virus after hepatitis B vaccination in egyptian diabetic children and adolescents","volume":"9","author":"Elrashidy","year":"2013","journal-title":"Hum Vaccine Immunother"},{"key":"2025070300084789400_fmaf026-B3","first-page":"112","article-title":"Serological response to vaccine in children with diabetes","volume":"74","author":"Dashti","year":"2015","journal-title":"Roum Arch Microbiol Immunol"},{"key":"2025070300084789400_fmaf026-B4","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1515\/jpem-2015-0211","article-title":"Seroprotection status of hepatitis B and measles vaccines in children with type 1 diabetes mellitus","volume":"29","author":"Onal","year":"2016","journal-title":"J Pediatr Endocrinol Metab"},{"key":"2025070300084789400_fmaf026-B5","first-page":"CD004407","article-title":"Vaccines for measles, mumps, rubella, and varicella in children","volume":"11","author":"Di Pietrantonj","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"2025070300084789400_fmaf026-B6","author":"National immunization schedule","year":"2021"},{"key":"2025070300084789400_fmaf026-B7","author":"Anthropometry Procedures Manual, National Health and Nutrition Examination Survey. 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