{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T19:07:37Z","timestamp":1754161657775,"version":"3.41.2"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Perinatal asphyxia (PA) is a global health concern associated with long-term morbidity and significant mortality. Limited finance and inadequate facilities are the bane of the low- and middle-income countries (LMICs) making the diagnosis of PA challenging. The identification of cheap, simple, specific, and sensitive, biochemical parameter as an alternative to blood gas analysis would improve the assessment of PA in LMICs. This study is designed to assess the utility of umbilical cord arterial blood (UCAB) lactate in diagnosis and prognosis of PA among term babies. This was a prospective, cross-sectional analytical study done at UBTH over a 7-month period. The inclusion criteria for PA were documented risk factors, Apearance, Pulse, Grimace, Activity, Respiration (APGAR) score of &amp;lt;7 in 5\u2009minutes, and umbilical cord pH \u22647.25. Samples were collected from the umbilical cord segments of 132 study participants and analysed using Abbott i-STAT. Sixty-six asphyxiated babies were the subjects for this study. The median (interquartile range) UCAB lactate value of the asphyxiated newborns was 7.23 (5.90\u20139.41) mmol\/l which is significantly higher than the apparently healthy newborns of 2.97 (2.27\u20133.82) mmol\/l (U\u2009=\u20094175.50; P\u2009&amp;lt;\u2009.001). The optimal diagnostic cut-off value of UCAB lactate in the diagnosis of PA was &amp;gt;5.1\u2009mmol\/l, with a sensitivity of 89.4% and specificity of 90.9%. The optimal cut-off value of UCAB lactate in predicting short-term adverse neonatal outcome (moderate to severe encephalopathy) was &amp;gt;8.32\u2009mmol\/l, having a sensitivity of 100% and specificity of 94.7%. UCAB lactate shows a good performance in the diagnosis of PA and prediction of short-term outcome among term neonates.<\/jats:p>","DOI":"10.1093\/tropej\/fmaf032","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T07:32:10Z","timestamp":1751959930000},"source":"Crossref","is-referenced-by-count":0,"title":["The utility of cord blood lactate as a low-resource tool in perinatal asphyxia diagnosis and prognosis; lessons from a tertiary hospital in Southern Nigeria"],"prefix":"10.1093","volume":"71","author":[{"given":"Chidiebere K","family":"Ani","sequence":"first","affiliation":[{"name":"Neonatal Division, Department of Child Health, University of Benin Teaching Hospital (UBTH) , P M B 1111 Benin City, Edo State, 300001,","place":["Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9359-8168","authenticated-orcid":false,"given":"Ikechukwu R","family":"Okonkwo","sequence":"additional","affiliation":[{"name":"Neonatal Division, Department of Child Health, University of Benin Teaching Hospital (UBTH) , P M B 1111 Benin City, Edo State, 300001,","place":["Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augustine I","family":"Omoigberale","sequence":"additional","affiliation":[{"name":"Neonatal Division, Department of Child Health, University of Benin Teaching Hospital (UBTH) , P M B 1111 Benin City, Edo State, 300001,","place":["Nigeria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"2025072901445686700_fmaf032-B1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2471\/BLT.07.049924","article-title":"Preventing those so-called stillbirths","volume":"86","author":"Spector","year":"2008","journal-title":"Bull World Health Organ"},{"author":"Federal Ministry of Health","key":"2025072901445686700_fmaf032-B2"},{"key":"2025072901445686700_fmaf032-B3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2471\/BLT.08.050963","article-title":"Neonatal mortality, risk factors and causes: a prospective population-based cohort study in urban Pakistan","volume":"87","author":"Jehan","year":"2009","journal-title":"Bull World Health Org"},{"key":"2025072901445686700_fmaf032-B4","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1080\/14767058.2017.1315094","article-title":"The introduction of umbilical cord lactate measurement and associated neonatal outcomes in a South African tertiary hospital labor ward","volume":"31","author":"Allanson","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"year":"2007","author":"Higgins","key":"2025072901445686700_fmaf032-B5"},{"key":"2025072901445686700_fmaf032-B6","first-page":"453","article-title":"Lactic acid: no longer an inert and end-product of glycolysis","volume":"32","author":"Sun","year":"2017","journal-title":"Physiology (Bethesda)"},{"key":"2025072901445686700_fmaf032-B7","first-page":"15","article-title":"Fetal distress: information provided by lactate levels and antioxidant status, compared with the APGAR score","volume":"19","author":"Abessolo","year":"2009","journal-title":"Sante"},{"key":"2025072901445686700_fmaf032-B8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/s13104-018-3598-9","article-title":"Point-of-care umbilical arterial lactate and newborn outcomes in a low resource setting: cohort study","volume":"11","author":"Chilinda","year":"2018","journal-title":"BMC Res Notes"},{"key":"2025072901445686700_fmaf032-B9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0022-3476(05)82056-6","article-title":"New Ballard score, expanded to include extremely premature infants","volume":"119","author":"Ballard","year":"1991","journal-title":"J Pediatr"},{"key":"2025072901445686700_fmaf032-B10","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1159\/000165378","article-title":"Impact of delayed arterial cord blood sampling for lactate assay","volume":"95","author":"Dessolle","year":"2009","journal-title":"Neonatology"},{"key":"2025072901445686700_fmaf032-B11","doi-asserted-by":"crossref","first-page":"F342","DOI":"10.1136\/adc.2005.086744","article-title":"Effect of delayed sampling on umbilical cord arterial and venous lactate and blood gases in clamped and unclamped vessels","volume":"91","author":"Armstrong","year":"2006","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"year":"2020","author":"World Health Organization. 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