{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T03:01:59Z","timestamp":1785294119070,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multisystem inflammatory syndrome in children (MIS-C) is a severe hyperinflammatory condition that follows SARS-CoV-2 infection, characterized by persistent fever and multi-organ dysfunction. Cardiac involvement occurs in 67%\u201380% of cases, representing a critical clinical concern. Data from tropical and Caribbean regions remain limited in the global MIS-C literature. We conducted a cross-sectional study with retrospective data collection at Hospital Infantil Napole\u00f3n Franco Pareja, Colombia. Included patients were &amp;lt;18\u2009years with a MIS-C diagnosis per WHO\/CDC\/RCPCH criteria and positive SARS-CoV-2 serology. Cardiac involvement was defined by elevated troponin, abnormal echocardiography, or electrocardiogram changes. Among n\u2009=\u2009105 patients (median age 5\u2009years, 61% male), cardiac involvement occurred in 25.7% (n\u2009=\u200927). The median number of affected organ systems was 4 (IQR: 3-4). Coronary artery dilation was the predominant cardiac finding (37.0% of cardiac cases), followed by mitral regurgitation and elevated troponin (both 33.3%). No patients showed left ventricular ejection fraction &amp;lt;55%. Treatment included corticosteroids (92.4%), acetylsalicylic acid (91.4%), and immunoglobulin (70.5%). All patients survived to discharge (100% survival). One-month follow-up revealed persistent coronary dilation in 2.9%. MIS-C affects multiple organ systems with coronary artery dilation as the predominant cardiac manifestation in our population. Favorable acute outcomes were observed with the current management protocols, including 100% survival and brief hospitalizations. However, persistent cardiac abnormalities in a subset of patients emphasize the need for systematic cardiac surveillance. These findings from a tropical Caribbean population provide insights applicable to resource-limited settings in other low- and middle-income countries.<\/jats:p>","DOI":"10.1093\/tropej\/fmag029","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:48:39Z","timestamp":1775130519000},"source":"Crossref","is-referenced-by-count":1,"title":["Cardiac alterations associated with multisystem inflammatory syndrome in children related to COVID-19: a cross-sectional study from the Colombian Caribbean"],"prefix":"10.1093","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2432-5997","authenticated-orcid":false,"given":"Melissa","family":"Rivero Roca","sequence":"first","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Universidad del Sin\u00fa El\u00edas Bechara Zain\u00fam, Seccional Cartagena, Cartagena, 130014, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-6750","authenticated-orcid":false,"given":"Gennys","family":"Guti\u00e9rrez Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Universidad del Sin\u00fa El\u00edas Bechara Zain\u00fam, Seccional Cartagena, Cartagena, 130014, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2036-7251","authenticated-orcid":false,"given":"Aida Luz","family":"Figueroa Reyes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Universidad del Sin\u00fa El\u00edas Bechara Zain\u00fam, Seccional Cartagena, Cartagena, 130014, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4850-2941","authenticated-orcid":false,"given":"Mauricio","family":"Guerrero Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Universidad del Sin\u00fa El\u00edas Bechara Zain\u00fam, Seccional Cartagena, Cartagena, 130014, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5040-6899","authenticated-orcid":false,"given":"Jaime","family":"Plazas Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Dentistry, Faculty of Dentistry, Universidad de Cartagena, Cartagena, 130001, Colombia"},{"name":"Department of Pediatric Dentistry, School of Dentistry, Universidad del Sin\u00fa El\u00edas Bechara Zain\u00fam, Seccional Cartagena, Cartagena, 130014, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-1416","authenticated-orcid":false,"given":"Carlos M","family":"Ardila","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University , Chennai 600077, Tamil Nadu,","place":["India"]},{"name":"Basic Sciences Department, Biomedical Stomatology Research Group, Faculty of Dentistry , Universidad de Antioquia U de A, Medell\u00edn 050010,","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"2026042910340225100_fmag029-B1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1161\/CIRCULATIONAHA.120.050065","article-title":"Acute cardiovascular manifestations in 286 children with multisystem inflammatory syndrome associated with COVID-19 infection in Europe","volume":"143","author":"Valverde","year":"2021","journal-title":"Circulation"},{"key":"2026042910340225100_fmag029-B2","doi-asserted-by":"publisher","first-page":"723654","DOI":"10.3389\/fimmu.2021.723654","article-title":"Multisystem inflammatory 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