{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:22:37Z","timestamp":1787444557347,"version":"build-2736575974"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"US National Institute of Health","award":["R33HD103093"],"award-info":[{"award-number":["R33HD103093"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In low-income, high HIV prevalence settings, caregiving for a young child who is HIV exposed and uninfected (HEU) can place additional demands on a mother living with HIV while she manages her own health and the well-being of her child. We compared caregiver burden associated with infants\u2019 healthcare needs, perceived by mothers of infants who were HEU and HIV-unexposed, uninfected (HUU). This nested sub-study of a prospective cohort study was conducted within the public primary healthcare setting in Western Cape, South Africa. Eligible mothers were enrolled antenatally with known HIV status and with a child confirmed HIV negative at age 12\u2009months by 20 May 2025. The primary exposure was maternal\u2013child HIV status, and primary outcome was caregiver burden according to the modified 12-item Zarit Caregiver Burden Scale questionnaire (ZCBS; range 0\u201348), measured by maternal interview at child\u2019s age 12\u2009months. Logistic regression was used to compare caregiver burden (no-to-mild [ZCBS 0\u201310] vs moderate-to-high [ZCBS 11\u201348]), unadjusted and adjusted for maternal and household confounders. Among 187 mothers included (n\u2009=\u200991 of infants HEU, n\u2009=\u200996 of infants HUU), the median (interquartile range) ZCBS was 3(1\u20138); 22\/91 (24.2%) mothers with HIV and 11\/96 (11.5%) mothers without HIV perceived moderate-to-high caregiver burden (unadjusted odds ratio 2.46, 95% confidence interval (CI)\u2009=\u20091.12\u20135.43, P\u2009=\u2009.025). After adjusting for maternal age, income, number of cohabitating adults in the family and maternal depression, the adjusted odds ratio was 2.06, 95% CI = 0.85\u20134.98, P\u2009=\u2009.108. Living with HIV while caring for an infant who is HEU increases mothers\u2019 caregiving burden during the critical period of early motherhood.<\/jats:p>","DOI":"10.1093\/tropej\/fmag054","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:37:44Z","timestamp":1785843464000},"source":"Crossref","is-referenced-by-count":0,"title":["Caregiver burden experienced by mothers of infants who are HIV exposed uninfected compared to infants HIV unexposed: A prospective cohort study in Worcester, South Africa"],"prefix":"10.1093","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8973-2272","authenticated-orcid":false,"given":"Himani","family":"Pandya","sequence":"first","affiliation":[{"name":"Department of Global Health, Faculty of Medicine & Health Sciences, Stellenbosch University , Western Cape, Cape Town, 8000,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2757-0663","authenticated-orcid":false,"given":"Peter S","family":"Nyasulu","sequence":"additional","affiliation":[{"name":"Division of Epidemiology & Biostatistics, Department of Global Health, Faculty of Medicine & Health Sciences, Stellenbosch University , Western Cape, Cape Town, 8000,","place":["South Africa"]},{"name":"School of Public Health, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg, 2193,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7531-6665","authenticated-orcid":false,"given":"Xanthe","family":"Hunt","sequence":"additional","affiliation":[{"name":"Africa Health Research Institute, Somkhele , KwaZulu Natal, 3935,","place":["South Africa"]},{"name":"Department of Global Health, Institute for Life Course Health Research, Stellenbosch University , Western Cape, Cape Town, 8000,","place":["South Africa"]},{"name":"Mental Health, Alcohol, Substance Use and Tobacco Research Unit (MAST-RU), South African Medical Research Council , Western Cape, Cape Town, 7505,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-9268","authenticated-orcid":false,"given":"Amy L","family":"Slogrove","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine & Health Sciences, Stellenbosch University , Western Cape, Cape Town, 8000,","place":["South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,22]]},"reference":[{"key":"2026082219595253700_fmag054-B1","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1590\/0104-1169.0196.2613","article-title":"Burden and quality of life of mothers of children and adolescents with chronic illnesses: an integrative 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