{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:47:57Z","timestamp":1784314077866,"version":"3.55.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"DOI":"10.1093\/tropej\/fmi052","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T00:14:05Z","timestamp":1119312845000},"page":"328-333","source":"Crossref","is-referenced-by-count":16,"title":["Characterisation of \u03b2-globin Gene Mutations in Malaysian Children: A Strategy for the Control of \u03b2-Thalassaemia in a Developing Country"],"prefix":"10.1093","volume":"51","author":[{"given":"Meow-Keong","family":"Thong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A. M. A.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. L.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. F.","family":"Yap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,6,20]]},"reference":[{"key":"key\n\t\t\t\t20171013183553_BIB1","unstructured":"Weatherall DJ, Clegg JB. Thalassaemia \u2013 a global public health problem. Nature Med1996; 3: 47\u20139."},{"key":"key\n\t\t\t\t20171013183553_BIB2","doi-asserted-by":"crossref","unstructured":"Caro JJ, Ward A, Green TC, et al. Impact of thalassemia major on patients and their families. Acta Haematol2002; 107: 150\u201357.","DOI":"10.1159\/000057633"},{"key":"key\n\t\t\t\t20171013183553_BIB3","doi-asserted-by":"crossref","unstructured":"Angastiniotis M. Modell B. Global epidemiology of haemoglobin disorders. Ann NY Acad Sci1998; 850: 251\u201369.","DOI":"10.1111\/j.1749-6632.1998.tb10482.x"},{"key":"key\n\t\t\t\t20171013183553_BIB4","doi-asserted-by":"crossref","unstructured":"Angastinoitis MA. Prevention of thalassaemia in Cyprus. Lancet1981; 369\u201370.","DOI":"10.1016\/S0140-6736(81)91682-2"},{"key":"key\n\t\t\t\t20171013183553_BIB5","unstructured":"Angastinoitis M, Modell B, Englezos P, et al. Prevention and control of haemoglobinopathies. Bulletin of the WHO1995; 73(3): 375\u201386."},{"key":"key\n\t\t\t\t20171013183553_BIB6","doi-asserted-by":"crossref","unstructured":"Karnon J, Zeuner D, Brown J, et al. Lifetime treatment costs of beta-thalassemia major. Clin Lab Haematol1999; 21: 377\u201385.","DOI":"10.1046\/j.1365-2257.1999.00262.x"},{"key":"key\n\t\t\t\t20171013183553_BIB7","doi-asserted-by":"crossref","unstructured":"Ostrowsky J, Lippman A, Scriver C. Cost-benefit analysis of a thalassemia disease prevention program. Am J Public Health1985; 75: 732\u201336.","DOI":"10.2105\/AJPH.75.7.732"},{"key":"key\n\t\t\t\t20171013183553_BIB8","doi-asserted-by":"crossref","unstructured":"Baysal E, Carver MFH. The \u03b2 and \u03b4 thalassaemia repository. Hemoglobin1995; 19: 213.","DOI":"10.3109\/03630269509036943"},{"key":"key\n\t\t\t\t20171013183553_BIB9","unstructured":"Huisman THJ, Carver MFH, Baysal E. A syllabus of thalassaemia mutations1997. http:\/\/globin.cse.psu.edu."},{"key":"key\n\t\t\t\t20171013183553_BIB10","doi-asserted-by":"crossref","unstructured":"Kazazian H, Boehm CD. Molecular basis and prenatal diagnosis of \u03b2-thalassaemia. Blood1988; 72: 1107\u2013116.","DOI":"10.1182\/blood.V72.4.1107.bloodjournal7241107"},{"key":"key\n\t\t\t\t20171013183553_BIB11","doi-asserted-by":"crossref","unstructured":"George E, Li HJ, Fei YJ, et al. Types of thalassaaemia among patients attending a large university clinic in Kuala Lumpur, Malaysia. Hemoglobin1992; 16: 51\u201366.","DOI":"10.3109\/03630269209005676"},{"key":"key\n\t\t\t\t20171013183553_BIB12","unstructured":"George E, Khuzaiah R. Malays with thalassaemias in West Malaysia. J Trop Geog Med1984; 36: 123\u201325."},{"key":"key\n\t\t\t\t20171013183553_BIB13","unstructured":"George-Kodiseri E, Yang KG, Kutlar F, et al. Chinese in West Malaysia: The geography of \u03b2-thalassaemia mutations. Singapore Med J1990; 31: 374\u201377."},{"key":"key\n\t\t\t\t20171013183553_BIB14","unstructured":"George E, George R, Ariffin WA, et al. Spectrum of \u03b2-thalassaemia mutations in transfusion dependent thalassaemia patients: practical implications in prenatal diagnosis. Med J Malaysia1993; 48: 325\u201329."},{"key":"key\n\t\t\t\t20171013183553_BIB15","unstructured":"Ariffin WA, Normah J, Kham SKY, Tan JAMA. The spectrum of \u03b2-thalassaemia mutations in Malays in Singapore and Kelantan. Southeast Asian J Trop Med Public Health1996; 27: 164\u201368."},{"key":"key\n\t\t\t\t20171013183553_BIB16","unstructured":"Thong MK, Law HY, Ng ISL. Molecular heterogeneity of \u03b2-thalassaemia in Malaysia: a practical approach to diagnosis. Ann Acad Med Singapore1996; 25: 79\u201383."},{"key":"key\n\t\t\t\t20171013183553_BIB17","doi-asserted-by":"crossref","unstructured":"Thong MK, Rudzki Z, Hall J, Tan JAMA, Chan LL, Yap SF. A single large deletion accounts for all \u03b2-globin gene mutations in twenty families in Sabah (north Borneo), Malaysia. Human Mutation1999; 13: 413.","DOI":"10.1002\/(SICI)1098-1004(1999)13:5<413::AID-HUMU14>3.0.CO;2-H"},{"key":"key\n\t\t\t\t20171013183553_BIB18","unstructured":"Old JM, Higgs DR. Gene analysis. In: The Thalassaemias. Methods in haematology. Weatherall DJ (ed.), Churchill Livingstone, Edinburgh 1983; pp. 74\u201382."},{"key":"key\n\t\t\t\t20171013183553_BIB19","unstructured":"Tan JAMA, Yap SF, Tan KL, Thong MK. The use of the Amplification Refractory Mutation System (ARMS) as an effective and economical tool for prenatal diagnosis of \u03b2-thalassaemia in Malaysian subjects. Int Med Res J1999; 2: 65\u201368."},{"key":"key\n\t\t\t\t20171013183553_BIB20","doi-asserted-by":"crossref","unstructured":"Old JM, Varawalla NY, Weatherall DJ. Rapid detection and prenatal diagnosis of \u03b2-thalassaemia: studies in Indian and Cypriot populations in the UK. The Lancet1990; 336: 834\u201337.","DOI":"10.1016\/0140-6736(90)92338-I"},{"key":"key\n\t\t\t\t20171013183553_BIB21","doi-asserted-by":"crossref","unstructured":"Suhaib Ahmed, Mohammad Saleem, Nadra Sultana et al. Prenatal diagnosis of \u03b2-thalassaemia in Pakistan: experience in a Muslim country. Prenatal Diagnosis2000; 20: 378\u201383.","DOI":"10.1002\/(SICI)1097-0223(200005)20:5<378::AID-PD815>3.0.CO;2-7"},{"key":"key\n\t\t\t\t20171013183553_BIB22","doi-asserted-by":"crossref","unstructured":"Saiki RK, Gelfand DH, Stoffel S, et al. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science1988; 239: 487\u201391.","DOI":"10.1126\/science.239.4839.487"},{"key":"key\n\t\t\t\t20171013183553_BIB23","doi-asserted-by":"crossref","unstructured":"Waye JS, Eng B, Hunt JA, Chui DHK. Filipino \u03b2-thalassaemia due to a large deletion: Identification of the deletion endpoints and PCR-based diagnosis. Human Genet1994; 94: 530\u201332.","DOI":"10.1007\/BF00211021"},{"key":"key\n\t\t\t\t20171013183553_BIB24","doi-asserted-by":"crossref","unstructured":"Shpilberg O, Dorman J, Ferrell R, et al. The next stage: molecular epidemiology. J Clin Epidemiol1997; 50: 633\u201338.","DOI":"10.1016\/S0895-4356(97)00052-8"},{"key":"key\n\t\t\t\t20171013183553_BIB25","doi-asserted-by":"crossref","unstructured":"Khoury M, Yang Q. The future of genetic studies of complex human diseases: an epidemiologic perspective. Epidemiology1998; 9: 350\u201354.","DOI":"10.1097\/00001648-199805000-00023"},{"key":"key\n\t\t\t\t20171013183553_BIB26","doi-asserted-by":"crossref","unstructured":"Saxena R, Jain P, Thomas E, et al. Prenatal diagnosis of \u03b2-thalassaemia: experience in a developing country. Prenatal Diagnosis1998; 18: 1\u20137.","DOI":"10.1002\/(SICI)1097-0223(199801)18:1<1::AID-PD209>3.0.CO;2-Y"},{"key":"key\n\t\t\t\t20171013183553_BIB27","doi-asserted-by":"crossref","unstructured":"Ahmed S, Saleem M, Sultana N, et al. Prenatal diagnosis of \u03b2-thalassaemia in Pakistan: experience in a Muslim country. Prenatal Diagnosis2000; 20: 378\u201383.","DOI":"10.1002\/(SICI)1097-0223(200005)20:5<378::AID-PD815>3.0.CO;2-7"},{"key":"key\n\t\t\t\t20171013183553_BIB28","unstructured":"El-Harith, Kuhnau W, Schmidtke J, et al. Identification and clinical presentation of \u03b2-thalassaemia mutations in the eastern region of Saudi Arabia. J Med Genet1999; 36: 935\u201337."},{"key":"key\n\t\t\t\t20171013183553_BIB29","doi-asserted-by":"crossref","unstructured":"Tan KL, Tan JAMA, Wong YC, Wee YC, Thong MK, Yap SF. Combine-ARMS: A rapid and cost-effective protocol for molecular characterization of \u03b2-thalassaemia in Malaysia. Genet Test2001; 5: 17\u201322.","DOI":"10.1089\/109065701750168626"}],"container-title":["Journal of Tropical Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/tropej\/article-pdf\/51\/6\/328\/4609015\/fmi052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T21:39:15Z","timestamp":1586295555000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/tropej\/article\/51\/6\/328\/1631510\/Characterisation-of-\u03b2globin-Gene-Mutations-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,20]]},"references-count":29,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,6,20]]},"published-print":{"date-parts":[[2005,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/tropej\/fmi052","relation":{},"ISSN":["1465-3664","0142-6338"],"issn-type":[{"value":"1465-3664","type":"electronic"},{"value":"0142-6338","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,12]]},"published":{"date-parts":[[2005,6,20]]}}}