{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:24:03Z","timestamp":1758893043864},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To compare the effectiveness of lung lavage with surfactant vs. bolus surfactant treatment in meconium aspiration syndrome (MAS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and methods<\/jats:title>\n                  <jats:p>This randomized controlled trial included newborns ventilated with MAS. In lavage group (n\u2009=\u200917) 30\u2009ml\/kg of diluted porcine surfactant was instilled into the lung. In bolus group (n\u2009=\u200916) porcine surfactant (100\u2009mg\/kg) was administered as bolus. Respiratory outcomes and mortality were compared between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Duration of respiratory support was found to be similar between lavage and bolus groups (3 vs. 3.5\u2009days, p\u2009=\u20090.36). Death or requirement for extracorporeal membrane oxygenation (ECMO) was 12% vs. 6%; respectively (RR: 2, 95% CI 0.16\u201324.48; p\u2009=\u20091.0). Duration of oxygen therapy, high-frequency ventilation or inhaled nitric oxide requirement did not differ among the groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Lung lavage did not show any advantage over bolus therapy on duration of respiratory support. The incidence of pneumothorax and surfactant re-administration decreased nonsignificantly in lavage group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trial Registration<\/jats:title>\n                  <jats:p>We registered the trial to ClinicalTrials.gov (http:\/\/clinicaltrials.gov) under identifier NCT02041546.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Registry name<\/jats:title>\n                  <jats:p>Lung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/tropej\/fmy081","type":"journal-article","created":{"date-parts":[[2018,12,15]],"date-time":"2018-12-15T03:45:10Z","timestamp":1544845510000},"page":"491-497","source":"Crossref","is-referenced-by-count":9,"title":["Lung Lavage with Dilute Surfactant vs. Bolus Surfactant for Meconium Aspiration Syndrome"],"prefix":"10.1093","volume":"65","author":[{"suffix":"MD","given":"Sema","family":"Arayici","sequence":"first","affiliation":[{"name":"Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Fatma Nur","family":"Sari","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Gulsum","family":"Kadioglu Simsek","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Erbu","family":"Yarci","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Evrim","family":"Alyamac Dizdar","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Nurdan","family":"Uras","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Fuat Emre","family":"Canpolat","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Serife Suna","family":"Oguz","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"2019100305320615500_fmy081-B1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0031-3955(05)70025-0","article-title":"Meconium-stained amniotic fluid and the meconium aspiration syndrome. 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